cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV”

  • Daniel J. Brat
  • Kenneth Aldape
  • Howard Colman
  • Eric C. Holland
  • David N. Louis
  • Robert B. Jenkins
  • B. K. Kleinschmidt-DeMasters
  • Arie Perry
  • Guido Reifenberger
  • Roger Stupp
  • Andreas von Deimling
  • Michael Weller


The World Health Organization (WHO) central nervous system tumor classification represents the primary source of updates on diagnostic classes, grades and criteria [17]. However, recent and ongoing advances in our understanding of brain tumor molecular pathogenesis warrant more rapid integration of this information into clinical practice between WHO updates. To accomplish this, cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established in 2016 [15, 16]. Since then, cIMPACT-NOW has convened three separate working committees to address classification and grading questions and challenges. Working Committee 1 focused on a concern that the classification and grading of Isocitrate Dehydrogenase (IDH)-wildtype diffuse astrocytic gliomas do not reflect our current understanding of the molecular pathogenesis and clinical outcomes associated with these tumors.

Numerous high-profile publications have documented the distinct genetic...



This paper has been reviewed by the Steering Committee and Clinical Advisory Panel of cIMPACT-NOW [15, 16] and by the International Society of Neuropathology Executive.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Daniel J. Brat
    • 1
  • Kenneth Aldape
    • 2
  • Howard Colman
    • 3
  • Eric C. Holland
    • 4
  • David N. Louis
    • 5
  • Robert B. Jenkins
    • 6
  • B. K. Kleinschmidt-DeMasters
    • 7
  • Arie Perry
    • 8
  • Guido Reifenberger
    • 9
    • 10
  • Roger Stupp
    • 11
  • Andreas von Deimling
    • 12
    • 13
  • Michael Weller
    • 14
  1. 1.Department of Pathology, Robert H. Lurie Cancer CenterNorthwestern University Feinberg School of MedicineChicagoUSA
  2. 2.Laboratory of Pathology, Center for Cancer ResearchNational Cancer InstituteBethesdaUSA
  3. 3.Department of Neurosurgery, Huntsman Cancer CenterUniversity of UtahSalt Lake CityUSA
  4. 4.Department of Neurosurgery, Fred Hutchinson Cancer CenterUniversity of WashingtonSeattleUSA
  5. 5.Department of Pathology, Massachusetts General HospitalHarvard Medical SchoolBostonUSA
  6. 6.Department of Laboratory Medicine and PathologyMayo ClinicRochesterUSA
  7. 7.Department of PathologyUniversity of Colorado School of MedicineAuroraUSA
  8. 8.Department of PathologyUniversity of California San FranciscoSan FranciscoUSA
  9. 9.Department of NeuropathologyHeinrich Heine UniversityDüsseldorfGermany
  10. 10.German Cancer Consortium (DKTK), Partner Site Essen/DüsseldorfDüsseldorfGermany
  11. 11.Malnati Brain Tumor Institute, Robert H. Lurie Cancer CenterNorthwestern University Feinberg School of MedicineChicagoUSA
  12. 12.Department of Neuropathology, Institute of PathologyUniversity of HeidelbergHeidelbergGermany
  13. 13.Clinical Cooperation Unit NeuropathologyGerman Cancer Institute (DKFZ)HeidelbergGermany
  14. 14.Department of NeurologyUniversity Hospital and University of ZurichZurichSwitzerland

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