Acta Neuropathologica

, Volume 135, Issue 6, pp 969–971 | Cite as

The relationship between neurosurgical instruments and disease transmission: Society of British Neurological Surgeons perspective

  • Peter J. A. Hutchinson
  • Barrie White
  • Adel HelmyEmail author
  • John Thorne
  • Alistair Jenkins
  • Richard Kerr
  • Neil Kitchen
  • Paul May
  • on behalf of the Society of British Neurological Surgeons

Jaunmuktane et al. [4] present a series of four patients who underwent neurosurgical procedures during childhood or teenage years and presented with intracerebral haemorrhage approximately 3 decades later caused by severe cerebral amyloid angiopathy (CAA). They show that none carried pathogenic mutations associated with early Aβ pathology development. They also identified four patients from the literature with a history of neurosurgical intervention and subsequent development of CAA. The small number of patients selected from a large volume neurosurgical centre collected over 14 years (2002–2016) raises the possibility of a, necessarily, highly selected patient cohort with a high risk of bias particularly in the context of a national neuroscience centre that collates rare, complex and unusual pathology. The number of patients undergoing neurosurgical procedures in this centre is not quantified as a possible denominator although it appears two of the patients did not undergo their...


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Peter J. A. Hutchinson
    • 1
  • Barrie White
    • 2
  • Adel Helmy
    • 1
    Email author
  • John Thorne
    • 3
  • Alistair Jenkins
    • 4
  • Richard Kerr
    • 5
  • Neil Kitchen
    • 6
  • Paul May
    • 7
  • on behalf of the Society of British Neurological Surgeons
  1. 1.Division of Neurosurgery, Department of Clinical NeurosciencesUniversity of CambridgeCambridgeUK
  2. 2.Department of NeurosurgeryQueen’s Medical CentreNottinghamUK
  3. 3.Department of NeurosurgerySalford Royal Foundation TrustSalfordUK
  4. 4.Department of NeurosurgeryRoyal Victoria InfirmaryNewcastle upon TyneUK
  5. 5.Department of NeurosurgeryThe John Radcliffe HospitalOxfordUK
  6. 6.Victor Horsley Department of NeurosurgeryThe National Hospital for Neurology and NeurosurgeryLondonUK
  7. 7.Department of NeurosurgeryThe Walton Centre NHS Foundation TrustLiverpoolUK

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