The relationship between neurosurgical instruments and disease transmission: Society of British Neurological Surgeons perspective
Jaunmuktane et al.  present a series of four patients who underwent neurosurgical procedures during childhood or teenage years and presented with intracerebral haemorrhage approximately 3 decades later caused by severe cerebral amyloid angiopathy (CAA). They show that none carried pathogenic mutations associated with early Aβ pathology development. They also identified four patients from the literature with a history of neurosurgical intervention and subsequent development of CAA. The small number of patients selected from a large volume neurosurgical centre collected over 14 years (2002–2016) raises the possibility of a, necessarily, highly selected patient cohort with a high risk of bias particularly in the context of a national neuroscience centre that collates rare, complex and unusual pathology. The number of patients undergoing neurosurgical procedures in this centre is not quantified as a possible denominator although it appears two of the patients did not undergo their...
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