A specific antibody to detect transcription factor T-Pit: a reliable marker of corticotroph cell differentiation and a tool to improve the classification of pituitary neuroendocrine tumours
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Pituitary adenomas, or pituitary neuroendocrine tumours (PitNETs) according to a recent proposal , are classified based on expression of the anterior lobe pituitary hormones (ACTH, GH, Prolactin, TSH, FSH, LH and alpha-subunit of the glycoprotein hormones) . Cell differentiation in the adenohypophysis includes three main lineages, each dependent on specific transcription factors: T-Pit (T-box family member TBX19) regulates the proopiomelanocortin (POMC) lineage giving origin to the corticotrophs; Pit-1 determines the fate of somatotroph, lactotroph and thyrotroph cells, while development of FSH- and LH-producing gonadotrophs is regulated by SF-1 (steroidogenic factor-1) and GATA-2 [3, 4]. The nuclear expression of the pituitary specific transcription factors T-Pit, Pit-1 and SF-1 is retained in the pituitary tumour cells that are differentiated towards respective pituitary cell lineages and thus serves as a useful complement in the classification of PitNETs . PitNETs lacking...
This work was supported by The Swedish Cancer Society, Knut and Alice Wallenberg foundation and ALF-funding from the Uppsala University Hospital in Uppsala.
Compliance with ethical standards
Conflict of interest
Fredrik Pontén is a co-founder of Atlas Antibodies. The other authors have no conflicts of interest to disclose.
All patients whose tumour tissues have been used in the study provided written informed consent, and the regional ethical committee approved the project.
- 2.Osamura RY, Grossman A, Korbonits M et al (2017) Pituitary adenomas. In: Lloyd RV, Osamura RY, Klöppel G et al (eds) World health organization classification of tumours of endocrine organs, 4th edn. IARC Press, Lyon, pp 14–18Google Scholar