Brainstem angiocentric gliomas with MYB–QKI rearrangements
Angiocentric glioma is a low-grade CNS tumor typically found in the cerebral hemispheres where it causes refractory epilepsy . Surgical resection is often sufficient for seizure control and the rate of tumor recurrence is low . On pathology, this neoplasm shares some cytologic features with pilocytic astrocytoma but is differentiated by its specific vascular polarity, its infiltrative growth pattern, and its epithelial membrane antigen (EMA) immunoreactivity . In an initial study, a MYB–QKI rearrangement was present in 6 of 7 angiocentric gliomas and absent in 147 other gliomas, making it a potential diagnostic marker in ambiguous or atypical cases . A subsequent study of a large number of cerebral low-grade gliomas confirmed the specificity of MYB–QKI rearrangements for angiocentric gliomas . A midbrain tumor resembling angiocentric glioma was previously reported but the presence of the rearrangement was not assessed . Here, we report two cases of...
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