Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature
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Meningiomas not only occur sporadically or in the context of neurofibromatosis type 2, but can also be induced by radiation . High-dose radiation-induced meningiomas (Mrad) predominantly arise after radiation for other brain tumors (often in childhood) with doses of 40–60 Gy. Most low-dose Mrad have been detected in patients receiving 3–4 Gy to the scalp for tinea capitis [6, 9]. Analysis of these tumors is paradigmatic for radiation-induced tumorigenesis, particularly in the absence of a prior tumor and chemotherapy and a model for collateral exposure surrounding the target of high-dose irradiation. So far, little molecular overlap between Mrad and sporadic meningiomas has been detected [6, 9].
KeywordsMeningioma Radiation-induced tumors Mutational signatures NF2
We thank H-Y Nguyen, L Dörner, J Baron, K Lindenberg, U Lass, and J Meyer for skillful technical assistance and the Genome and Proteome Core Facility, High-Throughput Sequencing Unit of the DKFZ. This work was supported by the German Cancer Aid (110670, 110983), the Else Kröner-Fresenius Foundation (A_60), the DKFZ-HIPO through H033, the Hartmut Hoffmann-Berling International Graduate School (DH), the MD/PhD-program of the University Heidelberg (DH), and the Helmholtz International Graduate School for Cancer Research (UHT).
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