[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration
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Corticobasal degeneration (CBD) is a neurodegenerative disease characterized by the deposition of abnormally hyperphosphorylated 4-repeat (4R) tau in the brain . Recent advances in molecular neuroimaging include the production of positron emission tomography (PET) ligands that bind to abnormal tau in the brain. One such ligand, [18F]AV-1451, has been shown to bind to abnormal 3R + 4R tau in diseases such as Alzheimer’s disease . In addition, one case report found an association between antemortem [18F]AV-1451 and tau burden in an autopsied case with a mutation in the microtubule-associated protein tau gene with 3R + 4R tau . Autoradiographic studies however have found very little, if any, binding in diseases characterized by 4R-tau including CBD [6, 7, 8], and no PET-autopsy studies have been published for a 4R-tau disease.
KeywordsPositron Emission Tomography Grey Matter Volume Standard Uptake Ratio Ideomotor Apraxia Rolandic Operculum
This study was supported by NIH Grants R01-NS89757 (PI, Josephs) and R01-DC12519 (PI, Whitwell).