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Acta Neuropathologica

, Volume 132, Issue 2, pp 313–315 | Cite as

Significant association of cadaveric dura mater grafting with subpial Aβ deposition and meningeal amyloid angiopathy

  • Tsuyoshi Hamaguchi
  • Yu Taniguchi
  • Kenji Sakai
  • Tetsuyuki Kitamoto
  • Masaki Takao
  • Shigeo Murayama
  • Yasushi Iwasaki
  • Mari Yoshida
  • Hiroshi Shimizu
  • Akiyoshi Kakita
  • Hitoshi Takahashi
  • Hiroyoshi Suzuki
  • Hironobu Naiki
  • Nobuo Sanjo
  • Hidehiro Mizusawa
  • Masahito YamadaEmail author
Correspondence

Recently, the possibility of human-to-human transmission of cerebral β-amyloidosis has been suggested in autopsy studies of patients with iatrogenic Creutzfeldt–Jakob disease (CJD) associated with human growth hormone injection or dura mater graft [1, 3, 4]. To evaluate the possibility of iatrogenic transmission of cerebral β-amyloidosis in humans via cadaveric dura mater graft, we performed immunohistochemical studies on 16 patients with dura mater graft-associated CJD (dCJD) and 21 patients with sporadic CJD (sCJD) using antibodies against prion protein (PrP), amyloid β-protein (Aβ), phosphorylated tau, phosphorylated α-synuclein, and phosphorylated transactive response DNA-binding protein-43 (TDP-43) (see supplementary methods). There were no significant differences between patients with dCJD and sCJD with respect to age at death [mean ± SD (range) years: 63.1 ± 14.1 (35–81) and 63.4 ± 10.8 (35–80), respectively], sex distribution, duration of CJD [months: 18.1 ± 8.8 (7–41) and...

Keywords

Dura Mater Prion Protein Cerebral Amyloid Angiopathy Superficial Portion Deposition Score 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This study was supported by a Grant-in-Aid from the Research Committee of Prion Disease and Slow Virus Infection; a Grant-in-Aid from the Research Committee of Surveillance and Infection Control of Prion Disease, the Ministry of Health, Labour and Welfare of Japan; a Grant-in-Aid from the Research Committee of Molecular Pathogenesis and Therapies for Prion Disease and Slow Virus Infection, Agency for Medical Research and Development (AMED); a Grant-in-Aid from the JSPS KAKENHI (26430060); a Grant-in-Aid from Scientific Research on Innovative Area (Comprehensive Brain Science Network) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

Supplementary material

401_2016_1588_MOESM1_ESM.docx (43 kb)
Supplementary material 1 (DOCX 42 kb)
401_2016_1588_MOESM2_ESM.tif (10.9 mb)
Supplementary material 2 (TIFF 11178 kb)
401_2016_1588_MOESM3_ESM.tif (12.9 mb)
Supplementary material 3 (TIFF 13201 kb)

References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Tsuyoshi Hamaguchi
    • 1
  • Yu Taniguchi
    • 1
  • Kenji Sakai
    • 1
  • Tetsuyuki Kitamoto
    • 2
  • Masaki Takao
    • 3
    • 4
    • 5
  • Shigeo Murayama
    • 3
  • Yasushi Iwasaki
    • 6
  • Mari Yoshida
    • 6
  • Hiroshi Shimizu
    • 7
  • Akiyoshi Kakita
    • 7
  • Hitoshi Takahashi
    • 7
  • Hiroyoshi Suzuki
    • 8
  • Hironobu Naiki
    • 9
  • Nobuo Sanjo
    • 10
  • Hidehiro Mizusawa
    • 10
    • 11
  • Masahito Yamada
    • 1
    Email author
  1. 1.Department of Neurology and Neurobiology of AgingKanazawa University Graduate School of Medical ScienceKanazawaJapan
  2. 2.Department of Neurological Science, Graduate School of MedicineTohoku UniversitySendaiJapan
  3. 3.Department of NeuropathologyTokyo Metropolitan Institute of Gerontology, The Brain Bank for Aging ResearchTokyoJapan
  4. 4.Department of NeuropathologyMihara Memorial HospitalIsesakiJapan
  5. 5.Department of NeurologySaitama International Medical CenterHidakaJapan
  6. 6.Department of Neuropathology, Institute for Medical Science of AgingAichi Medical UniversityNagakuteJapan
  7. 7.Department of Pathology, Brain Research InstituteUniversity of NiigataNiigataJapan
  8. 8.Department of PathologyNotional Hospital Organization Sendai Medical CenterSendaiJapan
  9. 9.Division of Molecular Pathology, Department of Pathological Sciences, Faculty of Medical SciencesUniversity of FukuiFukuiJapan
  10. 10.Department of Neurology and Neurological Science, Graduate SchoolTokyo Medical and Dental UniversityTokyoJapan
  11. 11.Department of NeurologyNational Center of Neurology and PsychiatryKodairaJapan

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