Histological evidence of chronic traumatic encephalopathy in a large series of neurodegenerative diseases
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Chronic traumatic encephalopathy (CTE) is a long-term neurodegenerative consequence of repetitive traumatic brain injury (rTBI). The histological features of CTE are characterised by neurofibrillary tangles (NFTs) composed of both 3-repeat and 4-repeat tau isoforms and astrocytic tau pathology (ATs) commonly in the frontal and temporal cortices and are distinct from other tauopathies . The recent classification delineates 4 pathological stages with progression of tau pathology from multifocal (I and II) to widespread disease (III and IV) . Of 68 CTE cases in the McKee series with history of rTBIs, only 43 had pure CTE pathology, the other 25 cases (37 %) had co-morbid neurodegenerative disorders (NDDs) including Lewy body disease, motor neuron disease, Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTLD), Pick’s disease and progressive supranuclear palsy (PSP) . TDP-43 pathology was found in 85 % of CTE cases across all disease stages . Our group reported...
KeywordsMultiple System Atrophy Progressive Supranuclear Palsy Progressive Supranuclear Palsy Chronic Traumatic Encephalopathy Lewy Body Disease
Compliance with ethical standards
HL, KD, JLH and TR receive a research Grant from CBD solutions; JLH and TL receive Grants from the MSA Trust, ARUK and Parkinson’s UK. This research was partly supported by the NIHR Queen Square Biomedical Research Unit in Dementia based at University College London Hospitals, University College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.
Conflict of interest
The authors declare that they have no conflict of interest.
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