Acta Neuropathologica

, Volume 130, Issue 2, pp 299–301 | Cite as

Screening for α-synuclein immunoreactive neuronal inclusions in the hippocampus allows identification of atypical MSA (FTLD-synuclein)

  • Zdenek Rohan
  • Jasmin Rahimi
  • Serge Weis
  • Istvan Kapas
  • Eduard Auff
  • Nenad Mitrovic
  • Pawel P. Liberski
  • Beata Sikorska
  • Radoslav Matej
  • Gabor G. KovacsEmail author

Atypical multiple system atrophy (aMSA) is a term recently introduced by Aoki et al. to describe cases that show hallmark neuropathological changes of glial cytoplasmic inclusions (Papp–Lantos bodies) characteristic of MSA, while clinically presenting with frontotemporal dementia (FTD) syndromes associated with frontotemporal lobar degeneration (FTLD) and severe limbic and cortical α-synuclein neuronal pathology [2]. The authors evaluated FTD syndrome cases and showed that the evaluation of α-synuclein immunoreactive neuronal cytoplasmic inclusions (NCIs) in the hippocampus (dentate gyrus and CA1/Subiculum) seems to be of great importance [2]. We aimed to determine if these morphological features in the hippocampus are reliable to identify similar cases in our archives.

We evaluated α-synuclein immunostaining in the hippocampus from a cohort of 18 neuropathologically confirmed MSA cases [ 10]: all cases contained characteristic Papp–Lantos bodies and NCIs in the basal ganglia,...


Dentate Gyrus Multiple System Atrophy Progressive Supranuclear Palsy Neuronal Cytoplasmic Inclusion Neurofibrillary Degeneration 
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B. S., P. P. L., and G. G. K. are supported by ÖAD Austria-Poland (PL 04/2014) and the Healthy Ageing Research Centre project (REGPOT-2012-2013-1, 7FP). R. M. and Z. R. are supported by grant IGA NT12094-5 from Grant Agency of Ministry of Health of the Czech Republic. Z. R. was supported by AVASTipendium for Human Brain, Alzheimer Foundation and Avast project.

Compliance with ethical standards

Conflict of interest

The authors report no conflict of interest.

Supplementary material

401_2015_1455_MOESM1_ESM.pdf (72 kb)
Supplementary material 1 (PDF 72 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Zdenek Rohan
    • 1
    • 2
  • Jasmin Rahimi
    • 3
  • Serge Weis
    • 4
  • Istvan Kapas
    • 5
  • Eduard Auff
    • 6
  • Nenad Mitrovic
    • 7
  • Pawel P. Liberski
    • 8
  • Beata Sikorska
    • 8
  • Radoslav Matej
    • 1
    • 2
    • 9
  • Gabor G. Kovacs
    • 3
    Email author
  1. 1.Department of Pathology and Molecular MedicineThomayer HospitalPragueCzech Republic
  2. 2.Third Faculty of Medicine, Institute of PathologyCharles University in PraguePragueCzech Republic
  3. 3.Institute of NeurologyMedical University of ViennaViennaAustria
  4. 4.Laboratory of Neuropathology, Department of Pathology and NeuropathologyState Neuropsychiatric Hospital Wagner-Jauregg, Medical School, Johannes Kepler University LinzLinzAustria
  5. 5.Department of NeurologySt. Janos HospitalBudapestHungary
  6. 6.Department of NeurologyMedical University of ViennaViennaAustria
  7. 7.Department of NeurologySalzkammergut-KlinikumVöcklabruckAustria
  8. 8.Department of Molecular Pathology and Neuropathology, Chair of OncologyMedical University of LodzLodzPoland
  9. 9.Department of Neurology and Center of Clinical Neuroscience, First Faculty of MedicineCharles University in PraguePragueCzech Republic

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