Screening for α-synuclein immunoreactive neuronal inclusions in the hippocampus allows identification of atypical MSA (FTLD-synuclein)
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Atypical multiple system atrophy (aMSA) is a term recently introduced by Aoki et al. to describe cases that show hallmark neuropathological changes of glial cytoplasmic inclusions (Papp–Lantos bodies) characteristic of MSA, while clinically presenting with frontotemporal dementia (FTD) syndromes associated with frontotemporal lobar degeneration (FTLD) and severe limbic and cortical α-synuclein neuronal pathology . The authors evaluated FTD syndrome cases and showed that the evaluation of α-synuclein immunoreactive neuronal cytoplasmic inclusions (NCIs) in the hippocampus (dentate gyrus and CA1/Subiculum) seems to be of great importance . We aimed to determine if these morphological features in the hippocampus are reliable to identify similar cases in our archives.
KeywordsDentate Gyrus Multiple System Atrophy Progressive Supranuclear Palsy Neuronal Cytoplasmic Inclusion Neurofibrillary Degeneration
B. S., P. P. L., and G. G. K. are supported by ÖAD Austria-Poland (PL 04/2014) and the Healthy Ageing Research Centre project (REGPOT-2012-2013-1, 7FP). R. M. and Z. R. are supported by grant IGA NT12094-5 from Grant Agency of Ministry of Health of the Czech Republic. Z. R. was supported by AVASTipendium for Human Brain, Alzheimer Foundation and Avast project.
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Conflict of interest
The authors report no conflict of interest.