Acta Neuropathologica

, Volume 129, Issue 1, pp 151–153 | Cite as

Mixed glioma with molecular features of composite oligodendroglioma and astrocytoma: a true “oligoastrocytoma”?

  • Jason T. Huse
  • Eli L. Diamond
  • Lu Wang
  • Marc K. Rosenblum

The current World Health Organization (WHO) classification system designates oligoastrocytoma as a diffusely infiltrating glial neoplasm exhibiting morphological features of both astrocytoma and oligodendroglioma [4]. Perhaps not surprisingly, a broad spectrum of diffuse gliomas having varying proportions of oligodendroglial and astrocytic character falls into this diagnostic category, with the classification of each tumor as astrocytoma, oligodendroglioma, or oligoastrocytoma suffering from significant inter-observer variability [9]. Recent large-scale molecular profiling efforts [1, 2, 3, 10] have emphatically confirmed earlier work [6] indicating that the vast majority of oligoastrocytomas, in addition to harboring mutations in IDH1/2, exhibit the signature genomic abnormalities of either pure oligodendroglioma (1p/19q codeletion, CIC and FUBP1 mutations) or astrocytoma (ATRX mutation, TP53mutation) with almost complete mutual exclusivity. Moreover, studies to date, including a...


Astrocytoma Oligodendroglioma Diffuse Glioma Oligodendroglial Cell Oligodendroglial Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Jason T. Huse
    • 1
    • 2
  • Eli L. Diamond
    • 3
  • Lu Wang
    • 1
  • Marc K. Rosenblum
    • 1
  1. 1.Department of PathologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Human Oncology and Pathogenesis ProgramMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.Department of NeurologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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