Acta Neuropathologica

, Volume 125, Issue 3, pp 425–438

Sequence variants in eukaryotic translation initiation factor 4-gamma (eIF4G1) are associated with Lewy body dementia

  • Shinsuke Fujioka
  • Christina Sundal
  • Audrey J. Strongosky
  • Monica Case Castanedes
  • Rosa Rademakers
  • Owen A. Ross
  • Carles Vilariño-Güell
  • Matthew J. Farrer
  • Zbigniew K. Wszolek
  • Dennis W. Dickson
Original Paper

DOI: 10.1007/s00401-012-1059-4

Cite this article as:
Fujioka, S., Sundal, C., Strongosky, A.J. et al. Acta Neuropathol (2013) 125: 425. doi:10.1007/s00401-012-1059-4

Abstract

We recently reported a missense mutation and four variants in eukaryotic translation initiation factor 4-gamma (EIF4G1) associated with parkinsonism, dementia or both. In those with a positive family history, the mode of inheritance was autosomal dominant. Detailed neuropathologic descriptions of individuals with EIF4G1 genetic variants have not been reported. Herein, we report neuropathologic findings of three individuals from two American families with EIF4G1 variants. The patients had initial clinical presentations of dementia or parkinsonism and all had dementia at the time of autopsy. One family carried an EIF4G1 double variant, c.2056G>T (p.G686C) and c.3589C>T (p.R1197 W), and one family carried variant c.1505C>T (p.A502V). All three patients also carried at least one ε4 allele of apolipoprotein E. One individual presented with cognitive impairment without significant parkinsonism; one presented with memory problems followed by bradykinesia; and the third presented with cardinal signs of Parkinson’s disease, followed more than a year later by cognitive dysfunction. Pathological examination showed diffuse cortical Lewy bodies and Lewy neurites in all patients. A small subset of Lewy bodies and Lewy neurites were immunopositive for eIF4G1. All patients had moderate to frequent non-neuritic, cortical amyloid plaques, mostly medial temporal neurofibrillary pathology (Braak neurofibrillary tangle stages of II to IV), and minimal or no TDP-43 pathology. The results suggest that in some patients variants in EIF4G1 can be associated with pathology that has a high likelihood of association with clinical features of dementia with Lewy bodies.

Keywords

APOE Dementia with Lewy bodies Diffuse Lewy body disease EIF4G1 Parkinsonism α-Synuclein Tau 

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Shinsuke Fujioka
    • 1
  • Christina Sundal
    • 1
  • Audrey J. Strongosky
    • 1
  • Monica Case Castanedes
    • 2
  • Rosa Rademakers
    • 2
  • Owen A. Ross
    • 2
  • Carles Vilariño-Güell
    • 3
  • Matthew J. Farrer
    • 3
  • Zbigniew K. Wszolek
    • 1
  • Dennis W. Dickson
    • 2
    • 4
  1. 1.Departments of NeurologyMayo ClinicJacksonvilleUSA
  2. 2.Departments of NeuroscienceMayo ClinicJacksonvilleUSA
  3. 3.Department of Medical GeneticsUniversity of British ColumbiaVancouverUSA
  4. 4.Department of NeuropathologyMayo ClinicJacksonvilleUSA

Personalised recommendations