Acta Neuropathologica

, Volume 121, Issue 4, pp 555–557

Optineurin is co-localized with FUS in basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease

  • Hidefumi Ito
  • Kengo Fujita
  • Masataka Nakamura
  • Reika Wate
  • Satoshi Kaneko
  • Shoichi Sasaki
  • Kiyomi Yamane
  • Naoki Suzuki
  • Masashi Aoki
  • Noriyuki Shibata
  • Shinji Togashi
  • Akihiro Kawata
  • Yoko Mochizuki
  • Toshio Mizutani
  • Hirofumi Maruyama
  • Asao Hirano
  • Ryosuke Takahashi
  • Hideshi Kawakami
  • Hirofumi Kusaka
Correspondence

Supplementary material

401_2011_809_MOESM1_ESM.pdf (109 kb)
Supplementary material 1 (PDF 108 kb)

References

  1. 1.
    Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH Jr (2009) Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science 323:1205–1208PubMedCrossRefGoogle Scholar
  2. 2.
    Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, Kaji R, Kawakami H (2010) Mutations of optineurin in amyotrophic lateral sclerosis. Nature 465:223–226PubMedCrossRefGoogle Scholar
  3. 3.
    Mourelatos Z, Adler H, Hirano A, Donnenfeld H, Gonatas JO, Gonatas NK (1990) Fragmentation of the Golgi apparatus of motor neurons in amyotrophic lateral sclerosis revealed by organelle-specific antibodies. Proc Natl Acad Sci USA 87:4393–4395PubMedCrossRefGoogle Scholar
  4. 4.
    Munoz DG, Neumann M, Kusaka H, Yokota O, Ishihara K, Terada S, Kuroda S, Mackenzie IR (2009) FUS pathology in basophilic inclusion body disease. Acta Neuropathol 118:617–627PubMedCrossRefGoogle Scholar
  5. 5.
    Sahlender DA, Roberts RC, Arden SD, Spudich G, Taylor MJ, Luzio JP, Kendrick-Jones J, Buss F (2005) Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. J Cell Biol 169:285–295PubMedCrossRefGoogle Scholar
  6. 6.
    Uranishi H, Tetsuka T, Yamashita M, Asamitsu K, Shimizu M, Itoh M, Okamoto T (2001) Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator. J Biol Chem 276:13395–13401PubMedCrossRefGoogle Scholar
  7. 7.
    Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X, Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S, Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller CC, Shaw CE (2009) Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science 323:1208–1211PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Hidefumi Ito
    • 1
    • 2
  • Kengo Fujita
    • 1
  • Masataka Nakamura
    • 1
  • Reika Wate
    • 1
  • Satoshi Kaneko
    • 1
  • Shoichi Sasaki
    • 3
  • Kiyomi Yamane
    • 4
  • Naoki Suzuki
    • 5
  • Masashi Aoki
    • 5
  • Noriyuki Shibata
    • 6
  • Shinji Togashi
    • 7
  • Akihiro Kawata
    • 8
  • Yoko Mochizuki
    • 8
  • Toshio Mizutani
    • 8
  • Hirofumi Maruyama
    • 9
  • Asao Hirano
    • 10
  • Ryosuke Takahashi
    • 2
  • Hideshi Kawakami
    • 9
  • Hirofumi Kusaka
    • 1
  1. 1.Department of NeurologyKansai Medical UniversityOsakaJapan
  2. 2.Department of NeurologyKyoto University Graduate School of MedicineKyotoJapan
  3. 3.Department of NeurologyTokyo Women’s Medical UniversityTokyoJapan
  4. 4.Department of NeurologyOhta-Atami HospitalKoriyamaJapan
  5. 5.Department of NeurologyTohoku University School of MedicineSendaiJapan
  6. 6.Department of PathologyTokyo Women’s Medical UniversityTokyoJapan
  7. 7.Department of NeurologyKofu City HospitalKofuJapan
  8. 8.Department of Neurology and PathologyTokyo Metropolitan Neurological HospitalTokyoJapan
  9. 9.Department of Epidemiology, Research Institute for Radiation Biology and MedicineHiroshima UniversityHiroshimaJapan
  10. 10.Division of NeuropathologyMontefiore Medical CenterNew YorkUSA

Personalised recommendations