Acta Neuropathologica

, Volume 121, Issue 2, pp 279–281 | Cite as

R132H-mutation of isocitrate dehydrogenase-1 is not sufficient for HIF-1α upregulation in adult glioma

  • Susan C. Williams
  • Matthias A. Karajannis
  • Luis Chiriboga
  • John G. Golfinos
  • Andreas von Deimling
  • David Zagzag
Correspondence

References

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    Capper D, Weissert S, Balss J et al (2010) Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol 20:245–254CrossRefPubMedGoogle Scholar
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    Dang L, White DW, Gross S et al (2009) Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462:739–744CrossRefPubMedGoogle Scholar
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    Ichimura K, Pearson DM, Kocialkowski S et al (2009) IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas. Neuro Oncol 11:341–347CrossRefPubMedGoogle Scholar
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    Metellus P, Coulibaly B, Colin C et al (2010) Absence of IDH mutation identifies a novel radiologic and molecular subtype of WHO grade II gliomas with dismal prognosis. Acta Neuropathol 120:719–729CrossRefPubMedGoogle Scholar
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    Sanson M, Marie Y, Paris S et al (2009) Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas. J Clin Oncol 27:4150–4154CrossRefPubMedGoogle Scholar
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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Susan C. Williams
    • 1
    • 7
  • Matthias A. Karajannis
    • 2
    • 6
    • 7
  • Luis Chiriboga
    • 3
    • 6
    • 7
  • John G. Golfinos
    • 1
    • 6
    • 7
  • Andreas von Deimling
    • 8
    • 9
  • David Zagzag
    • 1
    • 4
    • 5
    • 6
    • 7
  1. 1.Department of NeurosurgeryNew York University School of MedicineNew YorkUSA
  2. 2.Division of Pediatric Hematology/Oncology, Department of PediatricsNew York University School of MedicineNew YorkUSA
  3. 3.Immunohistochemistry CoreNew York University School of MedicineNew YorkUSA
  4. 4.Division of Neuropathology, Department of PathologyNew York University School of MedicineNew YorkUSA
  5. 5.Microvascular and Molecular Neuro-oncology LaboratoryNew York University School of MedicineNew YorkUSA
  6. 6.New York University Cancer InstituteNew York University School of MedicineNew YorkUSA
  7. 7.New York University Langone Medical CenterNew York University School of MedicineNew YorkUSA
  8. 8.Department of NeuropathologyRuprecht-Karls-University HeidelbergHeidelbergGermany
  9. 9.Clinical Cooperation Unit NeuropathologyGerman Cancer Research CenterHeidelbergGermany

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