Advertisement

Acta Neuropathologica

, Volume 120, Issue 6, pp 827–828 | Cite as

Heterogeneous neuropathological findings in Parkinson’s disease with mild cognitive impairment

  • Charles H. Adler
  • John N. Caviness
  • Marwan N. Sabbagh
  • Holly A. Shill
  • Donald J. Connor
  • Lucia Sue
  • Virgilio G. H. Evidente
  • Erika Driver-Dunckley
  • Thomas G. Beach
Correspondence

Parkinson’s disease (PD) patients often develop mild cognitive impairment (PD-MCI) and dementia (PDD) [5, 8]. The pathologic substrate for PDD appears to be heterogeneous and includes Lewy bodies, Alzheimer’s disease (AD) pathology, and cerebrovascular disease [6, 7, 9, 10]. Neuropathological changes in PD-MCI have not been described.

We present eight PD-MCI cases clinically and neuropathologically characterized as previously described [2, 4, 5]. The cognitive battery assessed five domains (memory, frontal/executive, language, attention, and visuospatial) using previously described PD-MCI criteria [5]. Lewy bodies were staged using the Unified Lewy Body Staging System [3] while AD and cerebrovascular pathology were assessed using standardized procedures [4].

Of 356 subjects autopsied from 1987 to 2010, 80 had PD (21 PD-cognitively normal, 8 PD-MCI, 51 PDD). The 8 PD-MCI cases (2 females, 6 males) were Hoehn and Yahr stage 2–3, mean age 82.8 years (range 74–89), and mean PD duration...

Keywords

Mild Cognitive Impairment Lewy Body Neuritic Plaque Lewy Body Pathology Cerebrovascular Pathology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was funded by the Arizona Biomedical Research Commission (contracts 4001, 05-901, 0011, and 1001), the Michael J. Fox Foundation for Parkinson’s Research (Prescott Family Initiative), the Arizona Department of Health Services (contract 211002), and the National Institute on Aging (P30 AG19610).

Conflict of interest

The authors declare that they have no conflicts of interest.

References

  1. 1.
    Aarsland D, Perry R, Brown A, Larsen JP, Ballard C (2005) Neuropathology of dementia in Parkinson’s disease: a prospective, community-based study. Ann Neurol 58:773–776CrossRefPubMedGoogle Scholar
  2. 2.
    Adler CH, Hentz JG, Joyce JN, Beach T, Caviness JN (2002) Motor impairment in normal aging, clinically possible Parkinson’s disease, and clinically probable Parkinson’s disease: longitudinal evaluation of a cohort of prospective brain donors. Parkinsonism Relat Disord 9:103–110CrossRefPubMedGoogle Scholar
  3. 3.
    Beach TG, Adler CH, Lue L et al (2009) Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol 117:613–634CrossRefPubMedGoogle Scholar
  4. 4.
    Beach TG, Sue LI, Walker DG et al (2008) The Sun Health Research Institute Brain Donation Program: description and experience, 1987–2007. Cell Tissue Bank 9:229–245CrossRefPubMedGoogle Scholar
  5. 5.
    Caviness JN, Driver-Dunckley E, Connor DJ et al (2007) Defining mild cognitive impairment in Parkinson’s disease. Mov Disord 22:1272–1277CrossRefPubMedGoogle Scholar
  6. 6.
    Choi SA, Evidente VG, Caviness JN et al (2010) Are there differences in cerebral white matter lesion burdens between Parkinson’s disease patients with or without dementia? Acta Neuropathol 119:147–149CrossRefPubMedGoogle Scholar
  7. 7.
    Hurtig HI, Trojanowski JQ, Galvin J et al (2000) Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s disease. Neurology 54:1916–1921PubMedGoogle Scholar
  8. 8.
    Janvin CC, Larsen JP, Aarsland D, Hugdahl K (2006) Subtypes of mild cognitive impairment in Parkinson’s disease: progression to dementia. Mov Disord 21:1343–1349CrossRefPubMedGoogle Scholar
  9. 9.
    Jellinger KA (2006) Pathological substrate of dementia in Parkinson’s disease–its relation to DLB and DLBD. Parkinsonism Relat Disord 12:119–120CrossRefPubMedGoogle Scholar
  10. 10.
    Sabbagh MN, Adler CH, Lahti TJ et al (2009) Parkinson disease with dementia: comparing patients with and without Alzheimer pathology. Alzheimer Dis Assoc Disord 23:295–297CrossRefPubMedGoogle Scholar
  11. 11.
    Sabbagh MN, Shah F, Reid RT et al (2006) Pathologic and nicotinic receptor binding differences between mild cognitive impairment, Alzheimer disease, and normal aging. Arch Neurol 63:1771–1776CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Charles H. Adler
    • 1
  • John N. Caviness
    • 1
  • Marwan N. Sabbagh
    • 2
  • Holly A. Shill
    • 2
  • Donald J. Connor
    • 2
  • Lucia Sue
    • 3
  • Virgilio G. H. Evidente
    • 1
  • Erika Driver-Dunckley
    • 1
  • Thomas G. Beach
    • 3
  1. 1.Department of NeurologyMayo Clinic ArizonaScottsdaleUSA
  2. 2.Cleo Roberts Center for Clinical ResearchBanner Sun Health Research InstituteSun CityUSA
  3. 3.Civin Laboratory for NeuropathologyBanner Sun Health Research InstituteSun CityUSA

Personalised recommendations