Acta Neuropathologica

, Volume 117, Issue 6, pp 713–718

Hippocampal sclerosis with four-repeat tau-positive round inclusions in the dentate gyrus: a new type of four-repeat tauopathy

  • Yasuo Miki
  • Fumiaki Mori
  • Emiko Hori
  • Mitsuomi Kaimori
  • Koichi Wakabayashi
Case Report

DOI: 10.1007/s00401-009-0531-2

Cite this article as:
Miki, Y., Mori, F., Hori, E. et al. Acta Neuropathol (2009) 117: 713. doi:10.1007/s00401-009-0531-2

Abstract

Hippocampal sclerosis is defined as selective neuronal loss and gliosis of the hippocampus with heterogeneous etiologies, including neurodegenerative tauopathies. We report a 78-year-old woman who presented with depression, in whom postmortem examination revealed almost complete loss of neurons with gliosis in the subiculum and CA1-3 regions of the hippocampus and abundant neuronal cytoplasmic inclusions in the dentate gyrus. The inclusions were round, slightly basophilic and argyrophilic, resembling Pick bodies. However, they were Gallyas- and 4-repeat tau-positive, and 3-repeat tau- and ubiquitin-negative. To our knowledge, the histopathological features in this case were different from those in hippocampal sclerosis or 4-repeat tauopathies reported previously. It is likely that this case is a new variant of 4-repeat tauopathy presenting with hippocampal sclerosis.

Keywords

Dentate gyrus Four-repeat tau Hippocampal sclerosis Pick body-like inclusion Tauopathy 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Yasuo Miki
    • 1
  • Fumiaki Mori
    • 1
  • Emiko Hori
    • 2
  • Mitsuomi Kaimori
    • 3
  • Koichi Wakabayashi
    • 1
  1. 1.Department of Neuropathology, Institute of Brain ScienceHirosaki University Graduate School of MedicineHirosakiJapan
  2. 2.Department of NeurosurgeryAomori Prefectural Central HospitalAomoriJapan
  3. 3.Department of PathologyAomori Prefectural Central HospitalAomoriJapan

Personalised recommendations