Acta Neuropathologica

, Volume 115, Issue 4, pp 437–444 | Cite as

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease

  • Dennis W. Dickson
  • Hiroshige Fujishiro
  • Anthony DelleDonne
  • Joshua Menke
  • Zeshan Ahmed
  • Kevin J. Klos
  • Keith A. Josephs
  • Roberta Frigerio
  • Melinda Burnett
  • Joseph E. Parisi
  • J. Eric Ahlskog
Original Paper


Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology.


Immunohistochemistry Incidental Lewy bodies Heart Parkinson’s disease Striatum Tyrosine hydroxylase 



This study is supported by the Morris K. Udall Center for Excellence in Parkinson’s Disease Research at Mayo Clinic (NIH P50-NS40256-09). The authors acknowledge Michael Oelkers and Allison Kendall for their efforts in acquiring tissue for these studies through the Mayo Tissue Registry. The assistance of Virginia Phillips, Linda Rousseau and Monica Casey-Castanedes for histologic and immunohistochemistry studies is also greatly appreciated.


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Dennis W. Dickson
    • 1
  • Hiroshige Fujishiro
    • 1
  • Anthony DelleDonne
    • 1
  • Joshua Menke
    • 1
  • Zeshan Ahmed
    • 1
  • Kevin J. Klos
    • 2
  • Keith A. Josephs
    • 4
  • Roberta Frigerio
    • 4
  • Melinda Burnett
    • 4
  • Joseph E. Parisi
    • 3
  • J. Eric Ahlskog
    • 4
  1. 1.Neuropathology Laboratory, Department of NeuroscienceMayo ClinicJacksonvilleUSA
  2. 2.Neurological Associates of TulsaTulsaUSA
  3. 3.Department of Pathology and Laboratory MedicineMayo ClinicRochesterUSA
  4. 4.Department of NeurologyMayo ClinicRochesterUSA

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