Acta Neuropathologica

, Volume 113, Issue 1, pp 101–103 | Cite as

Homozygous GAD65 and heterozygous GAD67 knock-out mice reveal normal retinal development and maintenance despite reduced amounts of GABA

  • Christian Albrecht May
  • Kouichi Nakamura
  • Fumino Fujiyama
  • Yukio Komatsu
  • Yuchio Yanagawa
Correspondence

References

  1. 1.
    de Melo J, Qiu X, Du G, Cristante L, Eisenstat DD (2003) Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina. J Comp Neurol 461:187–204PubMedCrossRefGoogle Scholar
  2. 2.
    Kaufman DL, Houser CR, Tobin AJ (1991) Two forms of the gammaaminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J Neurochem 56:720–723PubMedCrossRefGoogle Scholar
  3. 3.
    Stork O, Ji FY, Kaneko K, Stork S, Yoshinobu Y, Moriya T, Shibata S, Obata K (2000) Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65. Brain Res 865:45–58PubMedCrossRefGoogle Scholar
  4. 4.
    Tamamaki N, Yanagawa Y, Tomioka R, Miyazaki J, Obata K, Kaneko T (2003) Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. J Comp Neurol 467:60–79PubMedCrossRefGoogle Scholar
  5. 5.
    Young RW (1985) Cell differentiation in the retina of the mouse. Anat Rec 212:199–205PubMedCrossRefGoogle Scholar
  6. 6.
    Yanagawa Y, Kobayashi T, Ohnishi M, Kobayashi T, Tamura S, Tsuzuki T, Sanbo M, Yagi T, Tashiro F, Miyazaki J (1999) Enrichment and efficient screening of ES cells containing a targeted mutation: the use of DT-A gene with the polyadenylation signal as a negative selection maker. Transgenic Res 8:215– 221PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Christian Albrecht May
    • 1
  • Kouichi Nakamura
    • 2
  • Fumino Fujiyama
    • 2
  • Yukio Komatsu
    • 3
  • Yuchio Yanagawa
    • 4
  1. 1.Department of Anatomy, Carl Gustav Carus Medical FacultyTechnical University DresdenDresdenGermany
  2. 2.Department of Morphological Brain ScienceKyoto UniversityKyotoJapan
  3. 3.Department of Visual Neuroscience, Research Institute of Environmental MedicineNagoya UniversityNagoyaJapan
  4. 4.Department of Genetic and Behavioral NeuroscienceGunma University Graduate School of Medicine and SORST, JSTMaebashiJapan

Personalised recommendations