Acta Neuropathologica

, Volume 110, Issue 1, pp 77–83 | Cite as

Cerebellopontine calcification: a new entity of idiopathic intracranial calcification?

  • Yoshiaki Saito
  • Makoto Shibuya
  • Masaharu Hayashi
  • Shizuko Matsuoka
  • Kaori Kaneko
  • Yuri Chikumaru
  • Kazuyo Saito
  • Akira Matsui
  • Seiji Kimura
Case Report


We report the autopsy case of a 40-year-old woman with severe intellectual and motor disabilities, who showed calcification in the cerebellum and pons but not in the basal ganglia on CT scan, and died of intracranial hemorrhage due to intractable hypertension. At autopsy, numerous calcium deposits were noted in the cerebellar cortex, the dentate nucleus, the cerebellar white matter and the ventral pons. These deposits were distributed both in the neuropil and the white matter, but rarely within the arterial walls or in contact with capillaries. This weak relationship between calcification and the blood vessels, in addition to the paucity of basal ganglia calcification, is in contrast to the findings with other disorders involving intracranial calcification, including Fahr’s disease and calcium metabolism disorders. Immunohistochemistry revealed intense staining of calbindin-D28K and parvalbumin at sites of calcium deposits both in the present case and in a case of pseudohypoparathyroidism, whereas these proteins were not localized to calcium deposits in the cerebellum of a Fahr’s disease brain. We propose that the present case may represent a distinct entity among diseases characterized by idiopathic intracranial calcification. In addition, calcium-binding proteins may be involved in the calcification process in some cases with intracranial calcification.


Calcification Calcium-binding protein Cerebellum Immunohistochemistry Pons 


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Yoshiaki Saito
    • 1
    • 2
  • Makoto Shibuya
    • 3
  • Masaharu Hayashi
    • 4
  • Shizuko Matsuoka
    • 5
  • Kaori Kaneko
    • 1
    • 2
  • Yuri Chikumaru
    • 1
  • Kazuyo Saito
    • 1
  • Akira Matsui
    • 1
  • Seiji Kimura
    • 1
  1. 1.Department of Pediatrics and Pediatric NeurologyYokohama Ryo-iku Medical CenterYokohamaJapan
  2. 2.Department of PediatricsTokyo Women’s Medical UniversityTokyoJapan
  3. 3.Department of Laboratory MedicineTokai UniversityKanagawaJapan
  4. 4.Department of Clinical NeuropathologyTokyo Metropolitan Institute for NeuroscienceTokyoJapan
  5. 5.Department of NeurologyYokohama Stroke and Brain CenterYokohamaJapan

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