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Acta Neuropathologica

, Volume 109, Issue 6, pp 654–655 | Cite as

Mutations of the PIK3CA gene are rare in human glioblastoma

  • Wolf Mueller
  • Masahiro Mizoguchi
  • Erica Silen
  • Katrina D’Amore
  • Catherine L. Nutt
  • David N. Louis
Letter to the Editor

Keywords

PIK3CA Mutation Glioblastoma Cell Line PTEN Mutation Primary Glioblastoma PIK3CA Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Broderick DK, Di C, Parrett TJ, Samuels YR, Cummins JM, McLendon RE, Fults DW, Velculescu VE, Bigner DD, Yan H (2004) Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. Cancer Res 64:5048–5050PubMedGoogle Scholar
  2. 2.
    Hartmann C, Bartels G, Gehlhaar C, Holtkamp N, Deimling A von (2005) PIK3CA mutations in glioblastoma multiforme. Acta Neuropathol (this issue)Google Scholar
  3. 3.
    Hartmann C, Kluwe L, Lucke M, Westphal M (1999) The rate of homozygous CDKN2A/p16 deletions in glioma cell lines and in primary tumors. Int J Oncol 15:975–982PubMedGoogle Scholar
  4. 4.
    Ishii N, Maier D, Merlo A, Tada M, Sawamura Y, Diserens AC, Van Meir EG (1999) Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol 9:469–479PubMedGoogle Scholar
  5. 5.
    Mizoguchi M, Nutt CL, Mohapatra G, Louis DN (2004) Genetic alterations of phosphinositide 3-kinase subunit in human glioblastomas. Brain Pathol 14:372–377PubMedGoogle Scholar
  6. 6.
    Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304:554CrossRefPubMedGoogle Scholar
  7. 7.
    Sasaki H, Zlatescu MC, Betensky RA, Ino Y, Cairncross JG, Louis DN (2001) PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis. Am J Pathol 159:359–367PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Wolf Mueller
    • 1
  • Masahiro Mizoguchi
    • 1
  • Erica Silen
    • 1
  • Katrina D’Amore
    • 1
  • Catherine L. Nutt
    • 1
  • David N. Louis
    • 1
    • 2
  1. 1.Department of Pathology, Cancer Center and Neurosurgical ServiceMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Molecular Pathology Unit, 149–7151BostonUSA

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