Acta Neuropathologica

, Volume 109, Issue 6, pp 583–588 | Cite as

Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease

  • Satoshi Orimo
  • Takeshi Amino
  • Yoshinori Itoh
  • Atsushi Takahashi
  • Tohru Kojo
  • Toshiki Uchihara
  • Kuniaki Tsuchiya
  • Fumiaki Mori
  • Koichi Wakabayashi
  • Hitoshi Takahashi
Regular Paper

Abstract

Decreased cardiac uptake of meta-iodobenzylguanidine (MIBG) on [123I]MIBG myocardial scintigraphy has been reported in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). We hypothesized that cardiac sympathetic denervation might account for the pathomechanism. To elucidate the extent, frequency and pattern of cardiac sympathetic nerve involvement in Lewy body disease and related neurodegenerative disorders, we immunohistochemically examined heart tissues from patients with PD (n=11), DLB (n=7), DLB with Alzheimer’s disease (DLB/AD; n=4), multiple system atrophy (MSA; n=8), progressive supranuclear palsy (PSP; n=5), pure AD (n=10) and control subjects (n=5) together with sympathetic ganglia from patients with PD (n=5) and control subjects (n=4), using an antibody against tyrosine hydroxylase (TH). TH-immunoreactive nerve fibers in the hearts had almost entirely disappeared in nearly all the patients with PD, DLB and DLB/AD, whereas they were well preserved in all the patients with PSP and pure AD as well as in all except for one patient with MSA. In PD, neurons in the sympathetic ganglia were preserved in all except for one patient. Decreased cardiac uptake of MIBG in Lewy body disease reflects actual cardiac sympathetic denervation, which precedes the neuronal loss in the sympathetic ganglia.

Keywords

meta-iodobenzylguanidine Cardiac sympathetic denervation Sympathetic ganglia Parkinson’s disease Dementia with Lewy bodies 

Notes

Acknowledgements

We thank Dr. Iwatsubo for providing the phosphorylated α-synuclein antibody, and Ms. Yamada and Ms. Nakamura for their technical assistance. This work was supported in part by a grant from the Japan Foundation for Neuroscience and Mental Health (Tama Nakagawa Foundation).

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Satoshi Orimo
    • 1
  • Takeshi Amino
    • 1
  • Yoshinori Itoh
    • 2
  • Atsushi Takahashi
    • 3
  • Tohru Kojo
    • 4
  • Toshiki Uchihara
    • 4
  • Kuniaki Tsuchiya
    • 5
  • Fumiaki Mori
    • 6
  • Koichi Wakabayashi
    • 6
  • Hitoshi Takahashi
    • 7
  1. 1.Department of NeurologyKanto Central HospitalTokyoJapan
  2. 2.Department of Internal MedicineYokufukai Geriatric HospitalTokyoJapan
  3. 3.Organ and Function Pathology DivisionYokufukai Geriatric HospitalTokyoJapan
  4. 4.Department of NeuropathologyTokyo Metropolitan Institute for NeuroscienceTokyoJapan
  5. 5.Department of Laboratory Medicine and PathologyTokyo Metropolitan Matsuzawa HospitalTokyoJapan
  6. 6.Department of Neuropathology, Institute of Brain ScienceHirosaki University School of MedicineHirosakiJapan
  7. 7.Department of Pathology, Brain Research Institute University of NiigataNiigataJapan

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