Acta Neuropathologica

, Volume 109, Issue 2, pp 231–234 | Cite as

Ependymoma with neuropil-like islands: a case report with diagnostic and histogenetic implications

  • Marco Gessi
  • Carla Marani
  • Jennian Geddes
  • Antonella Arcella
  • Giovanna Cenacchi
  • Felice Giangaspero
Case Report


We describe a case of ependymoma with neuronal differentiation in form of neuropil-like islands. A 6-year-old boy presented at clinical examination for a short history of headaches and vomiting. Brain computed tomography showed a large, partially cystic, parieto-occipital lesion. The tumor was composed by glial fibrillary acidic protein-positive round cells with a perivascular arrangement and scattered neuropil-like islands, showing intense positivity for synaptophysin. Despite radiotherapy, the tumor recurred, showing frank features of anaplasia, but lacking the neuropil-like islands. The histological features of the tumor are discussed in the light of the concept that neuronal differentiation can occur occasionally in gliomas of different lineage without affecting the expected biological behavior.


Ependymoma Neuropil-like islands Neurocytic differentiation 


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Marco Gessi
    • 1
  • Carla Marani
    • 1
  • Jennian Geddes
    • 3
  • Antonella Arcella
    • 2
  • Giovanna Cenacchi
    • 4
  • Felice Giangaspero
    • 1
    • 2
    • 5
  1. 1.Department of Experimental Medicine and PathologyUniversity of Rome “La Sapienza”RomeItaly
  2. 2.IRCCS NeuromedPozzilliItaly
  3. 3.Department of Histopathology and Morbid AnatomyRoyal London HospitalLondonUK
  4. 4.Department of Radiology and PathologyUniversity of BolognaBolognaItaly
  5. 5.Neuropatologia c/o NeurochirurgiaPoliclinico Umberto IRomaItaly

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