Acta Neuropathologica

, Volume 106, Issue 5, pp 506–508 | Cite as

Rosette-forming glioneuronal tumor of the fourth ventricle

  • Matthias Preusser
  • Wolfgang Dietrich
  • Thomas Czech
  • Daniela Prayer
  • Herbert Budka
  • Johannes A. Hainfellner
Case Report

Abstract

Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle has been reported recently as a novel type of primary CNS neoplasm. We present the case of a 35-year-old male patient with RGNT of the fourth ventricle. The tumor was found incidentally; the patient did not suffer from any neurological symptoms. The tumor mass involved the caudal cerebellar vermis, filled the fourth ventricle and protruded into the caudal part of the mesencephalic aquaeduct. Smaller tumor nodules were visible in the adjacent right cerebellar hemisphere. Histologically, prominent neurocytic rosettes with synaptophysin expression were embedded in a glial tumor component resembling pilocytic astrocytoma. Clinicopathological features of our case closely resemble those reported in the original description. Thus, our case confirms RGNT as a new distinct type of primary CNS neoplasm. Due to its distinct features, adoption of RGNT as a new entity into the WHO classification of tumors should be considered.

Keywords

Glioneuronal tumor Fourth ventricle Cerebellum Synaptophysin 

Notes

Acknowledgements

This case study was performed within the Austrian Neuro-Oncology Network (ANN, www.ann.at).

References

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    Komori T, Scheithauer BW, Anthony DC, et al (1998) Papillary glioneuronal tumor: a new variant of mixed neuronal-glial neoplasm. Am J Surg Pathol 22:1171–1183CrossRefPubMedGoogle Scholar
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    Komori T, Scheithauer BW, Hirose T (2002) A rosette-forming glioneuronal tumor of the fourth ventricle: infratentorial form of dysembryoplastic neuroepithelial tumor? Am J Surg Pathol 26:582–591CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Matthias Preusser
    • 1
  • Wolfgang Dietrich
    • 2
  • Thomas Czech
    • 2
  • Daniela Prayer
    • 3
  • Herbert Budka
    • 1
  • Johannes A. Hainfellner
    • 1
  1. 1.Institute of NeurologyUniversity of Vienna, AKH 4JViennaAustria
  2. 2.Department of NeurosurgeryUniversity of ViennaViennaAustria
  3. 3.Department of NeuroradiologyUniversity of ViennaViennaAustria

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