Fractal analysis of viscoelastic data with automated gel point location and its potential application in the investigation of therapeutically modified blood coagulation
This study reports an automated numerical method for the location of the gel point in oscillatory shear data and demonstrates its potential application in measurements on therapeutically modified (heparinised) samples of healthy coagulating blood. Heparin prolongs the onset of clot formation and has a significant effect on the microstructure of the clot which is eventually formed. The results demonstrate the potential of this rheometrical technique as a new tool for monitoring the effect of heparin on samples of whole blood with significantly better linearity of response within the therapeutic range than another global coagulation monitoring technique (thromboelastography) which has previously been used.
KeywordsIncipient clot Anti-coagulant Fractal dimension Rheometry
The authors are grateful for the support of EPSRC grant EP/C513037/1 and a Royal Society Brian Mercer Feasibility Award in this work.
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