Colloid and Polymer Science

, Volume 279, Issue 7, pp 716–720 | Cite as

Comparison of the thermodynamic properties of structurally related amphiphilic antidepressants in aqueous solution

  • P. Taboada
  • J. M. Ruso
  • M. García
  • V. Mosquera
SHORT COMMUNICATION

Abstract

 The critical concentrations of amitriptyline, desipramine and nortriptyline hydrochlorides in aqueous solution were determined over the temperature range 288–313 K by a method based on deconvolution into Gaussians of the second derivate of the measured specific conductivity data. The mass-action model was used to calculate the thermodynamic quantities: standard free Gibbs energy, standard enthalpy and standard entropy of aggregate formation. The results are discussed in terms of the structure of the drug aggregates.

Key words Amitriptyline Desipramine Nortriptyline Critical micelle concentration Thermodynamic parameters 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • P. Taboada
    • 1
  • J. M. Ruso
    • 1
  • M. García
    • 1
  • V. Mosquera
    • 1
  1. 1.Grupo de Física de Coloides y Polímeros Departamento de Física de la Materia Condensada y Departamento de Física Aplicada, Facultad de Física Universidad de Santiago de Compostela 15706 Santiago de Compostela Spain e-mail: fmvictor@usc.es Tel.: +34-981-563100 Fax: +34-981-520676ES

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