Comparison of the thermodynamic properties of structurally related amphiphilic antidepressants in aqueous solution
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The critical concentrations of amitriptyline, desipramine and nortriptyline hydrochlorides in aqueous solution were determined over the temperature range 288–313 K by a method based on deconvolution into Gaussians of the second derivate of the measured specific conductivity data. The mass-action model was used to calculate the thermodynamic quantities: standard free Gibbs energy, standard enthalpy and standard entropy of aggregate formation. The results are discussed in terms of the structure of the drug aggregates.
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