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A novel stimulus-responsive temozolomide supramolecular vesicle based on host–guest recognition

  • Mingfang Ma
  • Lingdong Kong
  • Zhongyu Du
  • Zengyang Xie
  • Lin Chen
  • Ruijiao Chen
  • Zhenquan Li
  • Jun Liu
  • Zhaolou Li
  • Aiyou Hao
Original Contribution
  • 37 Downloads

Abstract

Temozolomide is a potent chemotherapeutic agent for glioblastoma multiforme treatment. However, its low aqueous solubility and short half-life (only about 1.8 h) in plasm limit its clinical therapeutics. Herein, a supramolecular vesicle based on hydroxypropyl-β-cyclodextrin and temozolomide was firstly constructed by elaborate design and preparation, which can load temozolomide into membranous layer of vesicle effectively. The morphologies and diameters of this temozolomide-loaded vesicle were characterized through transmission electron microscope, scanning electron microscope, and dynamic light scattering. The possible vesicle formation mechanism was further studied by X-ray diffraction, Fourier transform infrared spectrum, ultraviolet-visible spectroscopy, 1H nuclear magnetic resonance, and 2D nuclear magnetic resonance (ROSEY). Finally, the stimulus responsiveness of this vesicle was studied. Temozolomide can be released from the membrane of the vesicle once copper ions were dropped into the vesicle solution.

Graphical abstract

Herein, a novel supramolecular vesicle based on hydroxypropyl-β-cyclodextrin and temozolomide was constructed by elaborate design and preparation, which can load temozolomide into membranous layer of vesicle effectively. Moreover, hydroxypropyl-β-cyclodextrin/temozolomide vesicles exhibit sensitive stimulus responsiveness to copper ions since vesicles will change to irregular aggregates when copper ions are added into this vesicle system.

Keywords

Temozolomide Vesicle Hydroxypropyl-β-cyclodextrin Drug delivery 

Notes

Funding information

This study received financial support by the Support Funds for Teachers’ Scientific Research of Jining Medical University (NO. JYFC2018KJ045), PhD Start-up Scientific Research Foundation of Jining Medical University (NO. 2017JYQD03), National Natural Science Foundation of China (NO. 21872087), Shandong Science and Technology Development Plan (NO. 2016GGX107004), and Projects of Medical and Health Technology Development Program in Shandong Province (NO. 2017WS653).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

396_2018_4461_MOESM1_ESM.doc (6.5 mb)
ESM 1 (DOC 6673 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Mingfang Ma
    • 1
  • Lingdong Kong
    • 1
  • Zhongyu Du
    • 1
  • Zengyang Xie
    • 1
  • Lin Chen
    • 1
  • Ruijiao Chen
    • 1
  • Zhenquan Li
    • 1
  • Jun Liu
    • 1
  • Zhaolou Li
    • 1
  • Aiyou Hao
    • 2
  1. 1.Laboratory of New Antitumor Drug Molecular Design & Synthesis of Jining Medical University, College of Basic MedicineJining Medical UniversityJiningPeople’s Republic of China
  2. 2.Key Laboratory of Colloid and Interface Chemistry of Ministry of Education & School of Chemistry and Chemical EngineeringShandong UniversityJinanPeople’s Republic of China

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