Abstract
Molybdenum oxide, as one of the important transition metal semiconductor materials with photothermal property, has received increasing attention in the field of catalysis, sensing, energy storage, and clinical biomedicine. To improve its certain limitations such as poor biocompatibility and easy agglomeration during application as biomaterials and promote its performance as photothermal agent in biomedical fields, polyethylene glycol (PEG)–modified molybdenum oxide was synthesized and the synthesis conditions during the hydrothermal process, including the pH values and the amount of PEG added, were adjusted. Owing to the reduction function of PEG, as-obtained PEG-MoOx showed good photostability and colloidal stability, which were beneficial to its application in long-term clinical photothermal therapy. In addition, cell experiments indicated that PEG-MoOx particles exhibited low cytotoxicity and ability of photothermal killing for HeLa cells. With the increase PEG-MoOx particles in solution, the photothermal ablation ability of PEG-MoOx particles for the HeLa cells was enhanced under an 808-nm NIR laser irradiation. Hence, PEG-MoOx particles have great potential in the photothermal treatment of diseases.
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References
Fischervaluck BW, Rao YJ, Rudra S et al (2017) Treatment patterns and overall survival outcomes of octogenarians with muscle-invasive cancer of the bladder: an analysis of the national cancer database. J Urol 199:416–422
Zhang Z, Wang J, Chen C (2013) Near-infrared light-mediated nanoplatforms for cancer thermo-chemotherapy and optical imaging. Adv Mater 25:3869–3880
Liu Q, Sun C, He Q, Liu D, Khalil A, Xiang T, Wu Z, Wang J, Song L (2015) Ultrathin carbon layer coated MoO2 nanoparticles for high-performance near-infrared photothermal cancer therapy. Chem Commun 51:10054–10057
Cheng L, Liu JJ, Gu X, Gong H, Shi X, Liu T, Wang C, Wang X, Liu G, Xing H, Bu W, Sun B, Liu Z (2014) PEGylated WS2 nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy. Adv Mater 26:1886–1893
Huang P, Lin J, Li W, Rong P, Wang Z, Wang S, Wang X, Sun X, Aronova M, Niu G, Leapman RD, Nie Z, Chen X (2013) Biodegradable gold nanovesicles with ultra-strong plasmonic coupling effect for photoacoustic imaging and photothermal therapy. Angew Chem Int Edit 52:13958–13964
Zha ZB, Wang SM, Zhang SH, Qu E, Ke H, Wang J, Dai Z (2013) Targeted delivery of CuS nanoparticles through ultrasound image-guided microbubble destruction for efficient photothermal therapy. Nanoscale 5:3216–3219
Song GS, Hao JL, Liang C, Liu T, Gao M, Cheng L, Hu J, Liu Z (2016) Degradable molybdenum oxide nanosheets with rapid clearance and efficient tumor homing capabilities as a therapeutic nanoplatform. Angew Chem Int Ed 55:2122–2126
Gong H, Cheng L, Xiang J, Xu H, Feng L, Shi X, Liu Z (2013) Near-infrared absorbing polymeric nanoparticles as a versatile drug carrier for cancer combination therapy. Adv Funct Mater 23:6059–6067
Liu X, Tao H, Yang K, Zhang S, Lee ST, Liu Z (2011) Optimization of surface chemistry on single-walled carbon nanotubes for in vivo photothermal ablation of tumors. Biomaterials 32:144–151
Huang X, Elsayed IH, Qian W et al (2006) Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J Am Chem Soc 128:2115–2120
Su YY, Wei XP, Peng F, Zhong Y, Lu Y, Su S, Xu T, Lee ST, He Y (2012) Gold nanoparticles-decorated silicon nanowires as highly efficient near-infrared hyperthermia agents for cancer cells destruction. Nano Lett 12:1845–1850
Yang L, Tseng Y-T, Suo G, Chen L, Yu J, Chiu W-J, Huang C-C, Lin C-H (2015) Photothermal therapeutic response of cancer cells to aptamer–gold nanoparticle-hybridized graphene oxide under NIR illumination. ACS Appl Mater Interfaces 7:5097–5106
Tang S, Huang X, Zheng N (2011) Silica coating improves the efficacy of Pd nanosheets for photothermal therapy of cancer cells using near infrared laser. Chem Commun 47:3948–3950
Ke HT, Wang JR, Dai ZF, Jin Y, Qu E, Xing Z, Guo C, Yue X, Liu J (2011) Gold-nanoshelled microcapsules: a theranostic agent for ultrasound contrast imaging and photothermal therapy. Angew Chem Int Ed 50:3017–3021
Yu J, Lin Y-H, Yang L, Huang C-C, Chen L, Wang W-C, Chen G-W, Yan J, Sawettanun S, Lin C-H (2017) Improved anticancer photothermal therapy using the bystander effect enhanced by antiarrhythmic peptide conjugated dopamine-modified reduced graphene oxide nanocomposite. Adv Healthc Mater 6:1600804(1–9)
Liang C, Diao S, Wang C, Gong H, Liu T, Hong G, Shi X, Dai H, Liu Z (2014) Tumor metastasis inhibition by imaging-guided photothermal therapy with single-walled carbon nanotubes. Adv Mater 26:5646–5652
Wang XJ, Wang C, Cheng L, Lee ST, Liu Z (2012) Noble metal coated single-walled carbon nanotubes for applications in surface enhanced Raman scattering imaging and photothermal therapy. J Am Chem Soc 134:7414–7422
Chen M, Fang XL, Tang SH, Zheng N (2012) Polypyrrole nanoparticles for high-performance in vivo near-infrared photothermal cancer therapy. Chem Commun 48:8934–8936
Liu YL, Ai KL, Liu JH, Deng M, He Y, Lu L (2013) Dopamine-melanin colloidal nanospheres: an efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy. Adv Mater 25:1353–1359
Zha ZB, Yue XL, Ren QS, Dai Z (2013) Uniform polypyrrole nanoparticles with high photothermal conversion efficiency for photothermal ablation of cancer cells. Adv Mater 25:777–782
Liu T, Wang C, Cui W, Gong H, Liang C, Shi X, Li Z, Sun B, Liu Z (2014) Combined photothermal and photodynamic therapy delivered by PEGylated MoS2 nanosheets. Nanoscale 6:11219–11225
Yong Y, Zhou L, Gu Z, Yan L, Tian G, Zheng X, Liu X, Zhang X, Shi J, Cong W, Yin W, Zhao Y (2014) WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells. Nanoscale 6:10394–10403
Mou J, Li P, Liu CB, Xu H, Song L, Wang J, Zhang K, Chen Y, Shi J, Chen H (2015) Ultrasmall Cu2-xS nanodots for highly efficient photoacoustic imaging-guided photothermal therapy. Small 11:2275–2283
Hsu SW, On K, Tao AR (2011) Localized surface plasmon resonances of anisotropic semiconductor nanocrystals. J Am Chem Soc 133:19072–19075
Tian QW, Tang MH, Sun YG, Zou R, Chen Z, Zhu M, Yang S, Wang J, Wang J, Hu J (2011) Hydrophilic flower-like CuS superstructures as an efficient 980 nm laser-driven photothermal agent for ablation of cancer cells. Adv Mater 23:3542–3547
Zhou M, Zhang R, Huang M, Lu W, Song S, Melancon MP, Tian M, Liang D, Li C (2010) A chelator-free multifunctional [64-Cu] CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy. J Am Chem Soc 132:15351–15358
Liu XJ, Li B, Fu FF, Xu K, Zou R, Wang Q, Zhang B, Chen Z, Hu J (2014) Facile synthesis of biocompatible cysteine-coated CuS nanoparticles with high photothermal conversion efficiency for cancer therapy. Dalton Trans 43:11709–11715
Tian QW, Jiang FR, Zou RJ, Liu Q, Chen Z, Zhu M, Yang S, Wang J, Wang J, Hu J (2011) Hydrophilic Cu9S5 nanocrystals: a photothermal agent with a 25.7% heat conversion efficiency for photothermal ablation of cancer cells in vivo. ACS Nano 5:9761–9771
Wang XW, Miao ZH, Ma Y, Chen H, Qian H, Zha Z (2017) One-pot solution synthesis of shape-controlled copper selenide nanostructures and their potential applications in photocatalysis and photothermal therapy. Nanoscale 9:14512–14519
Hessel CM, Pattani VP, Rasch M, Panthani MG, Koo B, Tunnell JW, Korgel BA (2011) Copper selenide nanocrystals for photothermal therapy. Nano Lett 11:2560–2566
Liu XJ, Wang Q, Li C, Zou R, Li B, Song G, Xu K, Zheng Y, Hu J (2014) Cu2−xSe@mSiO2–PEG core–shell nanoparticles: a low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density. Nanoscale 6:4361–4370
Huang Q, Hu S, Zhuang J, Wang X (2012) MoO3-x-based hybrids with tunable localized surface plasmon resonances: chemical oxidation driving transformation from ultrathin nanosheets to nanotubes. Chem Eur J 18:15283–15287
Song GS, Shen J, Jiang FR, Hu R, Li W, An L, Zou R, Chen Z, Qin Z, Hu J (2014) Hydrophilic molybdenum oxide nanomaterials with controlled morphology and strong plasmonic absorption for photothermal ablation of cancer cells. Acs Appl Mater Inter 6:3915–3922
Chen J, Burger C, And C et al (2005) Morphogenesis of highly ordered mixed-valent mesoporous molybdenum oxides. J Am Chem Soc 127:14140–14141
Guo C, Yin S, Yan M, Kobayashi M, Kakihana M, Sato T (2012) Morphology-controlled synthesis of W18O49 nanostructures and their near-infrared absorption properties. Inorg Chem 51:4763–4771
Manthiram K, Alivisatos AP (2012) Tunable localized surface plasmon resonances in tungsten oxide nanocrystals. J Am Chem Soc 134:3995–3998
Zhou ZG, Kong B, Yu C et al (2014) Tungsten oxide nanorods: an efficient nanoplatform for tumor CT imaging and photothermal therapy. Sci Rep-Uk 4(1-10):3653
Li B, Zhang YX, Zou RJ, Wang Q, Zhang B, An L, Yin F, Hua Y, Hu J (2014) Self-assembled WO3−x hierarchical nanostructures for photothermal therapy with a 915 nm laser rather than the common 980 nm laser. Dalton Trans 43:6244–6250
Chen ZG, Wang Q, Wang HL, Zhang L, Song G, Song L, Hu J, Wang H, Liu J, Zhu M, Zhao D (2013) Ultrathin PEGylated W18O49 nanowires as a new 980 nm-laser-driven photothermal agent for efficient ablation of cancer cells in vivo. Adv Mater 25:2095–2100
Kanehara M, Koike H, Yoshinaga T, Teranishi T (2009) Indium tin oxide nanoparticles with compositionally tunable surface plasmon resonance frequencies in the near-IR region. J Am Chem Soc 131:17736–17737
Pan WZ, Tian RY, Jin H, Guo Y, Zhang L, Wu X, Zhang L, Han Z, Liu G, Li J, Rao G, Wang H, Chu W (2010) Structure, optical, and catalytic properties of novel hexagonal metastableh-MoO3 nano- and microrods synthesized with modified liquid-phase processes. Chem Mater 22:6202–6208
Fernandes CI, Capelli SC, Vaz PD, Nunes CD (2015) Highly selective and recyclable MoO3 nanoparticles in epoxidation catalysis. Appl Catal A Gen 504:344–350
Shen JL, Guo SJ, Chen C, Sun L, Wen S, Chen Y, Ruan S (2017) Synthesis of Ni-doped α-MoO3 nanolamella and their improved gas sensing properties. Sensors Actuators B Chem 252:757–763
Kim HS, Cook JB, Lin H, Ko JS, Tolbert SH, Ozolins V, Dunn B (2017) Oxygen vacancies enhance pseudocapacitive charge storage properties of MoO3-x. Nat Mater 16:454–460
Shi Y, Guo B, Corr SA, Shi Q, Hu YS, Heier KR, Chen L, Seshadri R, Stucky GD (2009) Ordered mesoporous metallic MoO2 materials with highly reversible lithium storage capacity. Nano Lett 9:4215–4220
Cheng H, Kamegawa T, Mori K, Yamashita H (2014) Surfactant-free nonaqueous synthesis of plasmonic molybdenum oxide nanosheets with enhanced catalytic activity for hydrogen generation from ammonia borane under visible light. Angew Chem Int Ed 53:2910–2914
Alsaif MMYA, Latham K, Field MR, Yao DD, Medehkar NV, Beane GA, Kaner RB, Russo SP, Ou JZ, Kalantar-zadeh K (2014) Tunable plasmon resonances in two-dimensional molybdenum oxide nanoflakes. Adv Mater 26:3931–3937
Ma M, Huang Y, Chen HR, Jia X, Wang S, Wang Z, Shi J (2015) Bi2S3-embedded mesoporous silica nanoparticles for efficient drug delivery and interstitial radiotherapy sensitization. Biomaterials 37:447–455
Bao T, Yin WY, Zheng XP, Zhang X, Yu J, Dong X, Yong Y, Gao F, Yan L, Gu Z, Zhao Y (2016) One-pot synthesis of PEGylated plasmonic MoO3–x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer. Biomaterials 76:11–24
Qi XF, Peng J, Tang DY, Wang N, Zou H (2017) PEGMa modified molybdenum oxide as a NIR photothermal agent for composite thermal/pH-responsive p (NIPAM-co-MAA) microgels. J Mater Chem C 5:8788–8795
Xu Y, Chen D, Jiao X, Xue K (2007) Nanosized Cu2O/PEG400 composite hollow spheres with mesoporous shells. J Phys Chem C 111:16284–16289
Gao Z, You C, Wu H, Wang M, Zhang X, Sun B (2018) FA and cRGD dual modified lipid-polymer nanoparticles encapsulating polyaniline and cisplatin for highly effective chemo-photothermal combination therapy. J Biomater Sci Polym Ed 29:397–411
Tan G, Li W, Cheng J, Wang Z, Wei S, Jin Y, Guo C, Qu F (2016) Magnetic iron oxide modified pyropheophorbide-a fluorescence nanoparticles as photosensitizers for photodynamic therapy against ovarian cancer (SKOV-3) cells. Photochem Photobiol Sci 15:1567–1578
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The studies were financially supported by the Excellent Academic Leaders Foundation of Harbin, China (No. 2014RFXXJ017).
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Zou, H., Tang, D., Wang, N. et al. Polyethylene glycol–modified molybdenum oxide as NIR photothermal agent and its ablation ability for HeLa cells. Colloid Polym Sci 297, 249–260 (2019). https://doi.org/10.1007/s00396-018-04460-8
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DOI: https://doi.org/10.1007/s00396-018-04460-8