Colloid and Polymer Science

, Volume 292, Issue 1, pp 251–255 | Cite as

Silica nanocapsules for redox-responsive delivery

  • Johannes Fickert
  • David Schaeffel
  • Kaloian Koynov
  • Katharina Landfester
  • Daniel Crespy
Short Communication
First Online:
Received:
Revised:
Accepted:

Abstract

Redox-responsive silica nanocapsules with a hydrophobic liquid core were synthesized by reactive templating of miniemulsion droplets with functional alkoxysilanes. Tetrasulfide bridges were successfully introduced into the inorganic shell and were found to be accessible for chemical reactions as shown by 31P-NMR spectroscopy. Indeed, the tetrasulfide groups could be reduced to yield thiol groups. A subsequent increase of permeability of the silica shell was observed upon reduction of the tetrasulfide groups.

Keywords

Encapsulation Miniemulsion Nanocapsules Nanoparticles Redox-responsive 
This is a preview of subscription content, log in to check access.

Notes

Acknowledgments

Sabrina Brand is acknowledged for her help in the project. Financial support from the DFG (SPP1568) and the joint cooperation program between the Fraunhofer and the Max Planck Societies are also acknowledged.

Supplementary material

396_2013_3105_MOESM1_ESM.docx (266 kb)
ESM 1 experimental section, chemical strcutures of the alkoxysilanes, scheme of the reduction reaction, TEM and SEM micrographs of functional silica nanocaspules, and evaluation procedure of the FCS data. (DOCX 265 kb)

References

  1. 1.
    Kemp M, Go YM, Jones DP (2008) Free Radic Biol Med 44:921CrossRefGoogle Scholar
  2. 2.
    Winterbourn CC, Hampton MB (2008) Free Radic Biol Med 45:549CrossRefGoogle Scholar
  3. 3.
    Yoon JA, Kamada J, Koynov, Mohin KJ, Nicolay R, Zhang YZ, Balazs AC, Kowalewski T, Matyjaszewski K (2012) Macromolecules 45:142CrossRefGoogle Scholar
  4. 4.
    Kamada J, Koynov K, Corten C, Juhari A, Yoon JA, Urban MW, Balazs AC, Matyjaszewski K (2010) Macromolecules 43:4133CrossRefGoogle Scholar
  5. 5.
    Saito G, Swanson JA, Lee KD (2003) Adv Drug Deliv Rev 55:199CrossRefGoogle Scholar
  6. 6.
    Kim E, Kim D, Jung H, Lee J, Paul S, Selvapalam N, Yang Y, Lim N, Park CG, Kim K (2010) Angew Chem Int Ed 49:4405CrossRefGoogle Scholar
  7. 7.
    Martinelli J, Fekete M, Tei L, Botta M (2011) Chem Commun 47:3144CrossRefGoogle Scholar
  8. 8.
    Zelikin AN, Quinn JF, Caruso F (2006) Biomacromolecules 7:27CrossRefGoogle Scholar
  9. 9.
    Zelikin AN, Li Q, Caruso F (2006) Angew Chem Int Ed 118:7907CrossRefGoogle Scholar
  10. 10.
    Yan Y, Johnston APR, Dodds SJ, Kamphuis MMJ, Ferguson C, Parton RG, Nice EC, Heath JK, Caruso F (2010) ACS Nano 4:2928CrossRefGoogle Scholar
  11. 11.
    Shu S, Zhang X, Wu Z, Wang Z, Li C (2010) Biomaterials 31:6039CrossRefGoogle Scholar
  12. 12.
    Zhao M, Biswas A, Hu B, Joo KI, Wang P, Gu Z, Tang Y (2011) Biomaterials 32:5223CrossRefGoogle Scholar
  13. 13.
    Yan L, Wang ZK, Yan JJ, Han LF, Zhou QH (2013) Polym Chem 4:1243CrossRefGoogle Scholar
  14. 14.
    Huang X, Appelhans D, Formanek P, Simon F, Voit B (2012) ACS Nano 6:9718CrossRefGoogle Scholar
  15. 15.
    Trewyn BG, Slowing II, Giri S, Chen HT, Lin VSY (2007) Acc Chem Res 40:846CrossRefGoogle Scholar
  16. 16.
    Piao Y, Burns A, Kim J, Wiesner U, Hyeon T (2008) Adv Funct Mater 18:3745CrossRefGoogle Scholar
  17. 17.
    Radu DR, Lai CY, Huang J, Shu Y, Lin VSY (2005) Chem. Commun. 1264Google Scholar
  18. 18.
    Sauer AM, Schlossbauer A, Ruthardt N, Cauda V, Bein T, Bräuchle C (2010) Nano Lett 10:3684CrossRefGoogle Scholar
  19. 19.
    Staff RH, Rupper P, Lieberwirth I, Landfester K, Crespy D (2011) Soft Matter 7:10219CrossRefGoogle Scholar
  20. 20.
    Zhao Y, Fickert J, Landfester K, Crespy D (2012) Small 8:2954CrossRefGoogle Scholar
  21. 21.
    Fickert J, Wohnhaas C, Turshatov A, Landfester K, Crespy D (2013) Macromolecules 46:573CrossRefGoogle Scholar
  22. 22.
    Zhao Y, Landfester K, Crespy D (2012) Soft Matter 8:11687CrossRefGoogle Scholar
  23. 23.
    Staff RH, Gallei M, Mazurowski M, Rehahn M, Berger R, Landfester K, Crespy D (2012) ACS Nano 6:9042CrossRefGoogle Scholar
  24. 24.
    Crespy D, Stark M, Hoffmann-Richter C, Ziener U, Landfester K (2007) Macromolecules 40:3122CrossRefGoogle Scholar
  25. 25.
    Fickert J, Makowski M, Kappl M, Landfester K, Crespy D (2012) Macromolecules 45:6324CrossRefGoogle Scholar
  26. 26.
    Fickert J, Rupper P, Graf R, Landfester K, Crespy D (2012) J Mater Chem 22:2286CrossRefGoogle Scholar
  27. 27.
    Hashim AS, Azahari B, Ikeda Y, Kohjiya S (1998) Rubber Chem Technol 71:289CrossRefGoogle Scholar
  28. 28.
    De D, Das A, De D, Panda PK, Dey B, Roy BC (2006) J Appl Polym Sci 99:957CrossRefGoogle Scholar
  29. 29.
    Ansarifar A, Wang L, Ellis J, Kirtley SP (2006) Rubber Chem Technol 79:39CrossRefGoogle Scholar
  30. 30.
    Tangpasuthadol V, Intasiri A, Nuntivanich D, Niyompanich N, Kiatkamjornwong S (2008) J Appl Polym Sci 109:424CrossRefGoogle Scholar
  31. 31.
    Wu YP, Zhao QS, Zhao SH, Zhang LQ (2008) J Appl Polym Sci 108:112CrossRefGoogle Scholar
  32. 32.
    Das A, Jurk R, Stockelhuber KW, Heinrich G (2008) J Macromol Sci A 45:101CrossRefGoogle Scholar
  33. 33.
    Seo G, Park SM, Ha K, Choi KT, Hong CK, Kaang S (2010) J Mater Sci 45:1897CrossRefGoogle Scholar
  34. 34.
    Scotti R, Wahla L, Crippa M, D'Arienzo M, Donetti R, Santo N, Morazzoni F (2012) Soft Matter 8:2131CrossRefGoogle Scholar
  35. 35.
    Montemor MF, Cabral AM, Zheludkevich ML, Ferreira MGS (2006) Surf Coat Technol 200:2875CrossRefGoogle Scholar
  36. 36.
    Guo LM, Li JT, Zhang LX, Li JB, Li YS, Yu CC, Shi JL, Ruan ML, Feng JW (2008) J Mater Chem 18:2733CrossRefGoogle Scholar
  37. 37.
    Burns JA, Butler JC, Moran J, Whitesides GM (1991) J Org Chem 56:2648CrossRefGoogle Scholar
  38. 38.
    Han JC, Han GY (1994) Anal Biochem 220:5CrossRefGoogle Scholar
  39. 39.
    Dmitrenko O, Thorpe C, Bach RD (2007) J Org Chem 72:8298CrossRefGoogle Scholar
  40. 40.
    Krezel A, Latajka R, Bujacz GD, Bal W (2003) Inorg Chem 42:1994CrossRefGoogle Scholar
  41. 41.
    Rigler R, Mets Ü, Widengren J, Kask P (1993) Eur Biophys J Biophys 22:169CrossRefGoogle Scholar
  42. 42.
    Koynov K, Butt HJ (2012) Curr Opin Colloid Interface 17:377CrossRefGoogle Scholar
  43. 43.
    Florez L, Herrmann C, Cramer JM, Hauser CP, Koynov K, Landfester K, Crespy D, Mailander V (2012) Small 8:2222CrossRefGoogle Scholar
  44. 44.
    Schaeffel D, Staff RH, Butt HJ, Landfester K, Crespy D, Koynov K (2012) Nano Lett 12:6012CrossRefGoogle Scholar
  45. 45.
    Staff RH, Schaeffel D, Turshatov A, Donadio D, Butt HJ, Landfester K, Koynov K, Crespy D (2013) Small 9:3514Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Johannes Fickert
    • 1
  • David Schaeffel
    • 1
  • Kaloian Koynov
    • 1
  • Katharina Landfester
    • 1
  • Daniel Crespy
    • 1
  1. 1.Max Planck Institute for Polymer ResearchMainzGermany

Personalised recommendations