Colloid and Polymer Science

, Volume 291, Issue 1, pp 157–165 | Cite as

Drug release system of ibuprofen in PCL-microspheres

Original Contribution

Abstract

Today, the technology of microencapsulation of active principles is on top of biomedical advances, because through it we can solve many of the problems caused by current methods of taking medication. Active principle microencapsulation not only solves the problems of drug intake but also controls its dosage. In this study was carried out the development of a protocol for the microencapsulation of ibuprofen by solvent evaporation method. A subsequent application of those microencapsulates to biofunctional textile substrates (cotton, polyamide, acrylic, and polyester) using a finishing process, and finally a study of the release of active principle in two different media (deionized water and physiological serum) has been carried out using samples of the treated fabrics that were submerged into a thermostatized vessel at semi-infinite bath conditions. The determination of active principles released to the bath was determined by a UV spectrophotometer. These experimental results have been analyzed and evaluated, and have therefore allowed to define a controlled drug release system by Fickian diffusion in different media.

Keywords

Microcapsules Biofunctional textile substrates Drug release Ibuprofen 

Notes

Acknowledgements

The authors wish to thank the Spanish National Project (Ministerio de Educación y Ciencia) CTQ-PPQ2009-13967-C03-01 for the financial support.

References

  1. 1.
    Wang B, Siahaan T, Soltero R (2005) Drug delivery: principles and applications. Wiley, New JerseyCrossRefGoogle Scholar
  2. 2.
    Saez V, Hernández JR, Peniche C (2007) Las Microesferas como sistemas de liberación controlada de péptidos y proteínas. Biotecnol Apl 24:98–107Google Scholar
  3. 3.
    Bertram JP, Jay SM, Hynes SR, Robinson R, Criscione JM, Lavik EB (2009) Functionalized poly(lactic-co-glycolic acid) enhances drug delivery and provides chemical moieties for surface engineering while preserving biocompatibility. Acta Biomaterialia 5:2860–2871CrossRefGoogle Scholar
  4. 4.
    Sáez V, Hernáez E, Angulo LS (2004) Mecanismos de liberación de fármacos desde materiales polímeros. Rev Iberoam Polím 5:55–69Google Scholar
  5. 5.
    Sáez V, Hernáez E, Angulo LS (2002) Sistemas de liberación controlada de medicamentos. Rev Iberoam Polím 3:1–17Google Scholar
  6. 6.
    Sáez V, Hernández JR, Peniche C (2007) Las Microesferas como sistemas de liberación controlada de péptidos y proteínas. Biotecnol Apl 24:98–107Google Scholar
  7. 7.
    Sáez V, Hernáez E, Angulo LS, Katime I (2004) Liberación controlada de fármacos. Micropartículas. Rev Iberoam Polím 5:87–101Google Scholar
  8. 8.
    Kantor TG (1979) Ibuprofen. Ann Intern Med 91:877–882Google Scholar
  9. 9.
    Mathiowitz E (1999) Pharmacy—encyclopedia of controlled drug delivery, vol 1&2. Wiley, ProvidenceGoogle Scholar
  10. 10.
    Siepmann J, Peppas NA (2001) Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev 48:139–157CrossRefGoogle Scholar
  11. 11.
    Siepmann J, Kranz H, Bodmeier R, Peppas NA (1999) HPMC—matrices for controlled drug delivery: a new model combining diffusion, swelling, and dissolution mechanisms and predicting the release kinetics. Pharm Res 16(11):1748–1756CrossRefGoogle Scholar
  12. 12.
    Abdekhodaie MJ, Cheng Y-L (1997) Diffusional release of a dispersed solute from planar and spherical matrices into finite external volume. J Control Release 43:175–182CrossRefGoogle Scholar
  13. 13.
    Guisado García EI, Gil Alegre ME, Camacho Sanchez MA, Torres Suárez AI (2001) Estudio de solubilidad de ibuprofeno en medio acuoso: Elaboración de una formulación líquida de uso pediátrico. VI Congreso SEFIG y Tercera Jornada Tecnología Farmacéutica 162:161–164Google Scholar
  14. 14.
    Galindo-Rodríguez S, Allémann E, Fessi H, Doelker E (2005) Versatility of three techniques for preparing ibuprofen-loaded methacrylic acid copolymer nanoparticles of controlled sizes. J Drug Deliv Sci Technol 15(5):347–354Google Scholar
  15. 15.
    Kawashima Y, Niwa T, Handa T, Takeuchi H, Iwamoto T, Itoh K (1989) Preparation of controlled-release microspheres of ibuprofen with acrylic polymers by a novel quasi-emulsion solvent diffusion method. J Pharmaceut Sci 78:68–72CrossRefGoogle Scholar
  16. 16.
    Fu X, Ping Q, Gao Y (2005) Effects of formulation factors on encapsulation efficiency and release behavior in vitro of huperzine A-PLGA microspheres. J Microencapsul 22:705–714CrossRefGoogle Scholar
  17. 17.
    Wang C, Ye W, Zheng Y, Liu X, Tong Z (2007) Fabrication of drug-loaded biodegradable microcapsules for controlled release by combination of solvent evaporation and layer-by-layer self-assembly. Int J Pharm 338:165–173CrossRefGoogle Scholar
  18. 18.
    Matkovic SR, Valle GM, Galle M, Briand LE (2004) Desarrollo y Validación del Análisis Cuantitativo de Ibuprofeno en Comprimidos por Espectroscopia Infrarroja. Acta Farmacéutica Bonaer 23:527–532Google Scholar
  19. 19.
    Garrigues S, Gallignani M, De La Guardia M (1993) FIA-FT-IR determination of ibuprofen in pharmaceuticals. Talanta V40:89–93CrossRefGoogle Scholar
  20. 20.
    Sádecká J, Cakrt M, Hercegorá A, Polonsk J, Skaáni I (2001) Determination of ibuprofen and naproxen in tablets. J Pharm Biomed Anal 25:881–891CrossRefGoogle Scholar
  21. 21.
    Sheikh Hasan A, Socha M, Lamprecht A, El Ghazouani F, Sapin A, Hoffmana M, Maincent P, Ubrich N (2007) Effect of the microencapsulation of nanoparticles on the reduction of burst effect. Int J Pharm 344:53–61CrossRefGoogle Scholar
  22. 22.
    Leo E, Forni F, Bernabei MT (2000) Surface drug removal from ibuprofen-loaded PLA microspheres. Int J Pharm 196:1–9CrossRefGoogle Scholar
  23. 23.
    Baruch L, Benny O, Gilert A, Ukobnik M, Ben Itzhak O, Machluf M (2009) Alginate-PLL cell encapsulation system co-entrapping PLGA-microspheres for the continuous release of anti-inflammatory drugs. Biomed Microdev 11:1103–1113CrossRefGoogle Scholar
  24. 24.
    Yang YY, Chia HH, Chung TS (2000) Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method. J Controll Release 69:81–96CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Department of Chemical EngineeringPolytechnic University of CataloniaTerrassaSpain
  2. 2.Institut de Química Avançada de Catalunya, (IQAC-CSIC)BarcelonaSpain
  3. 3.INTEXTER-UPC. Polquitex Research GroupTerrassaSpain

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