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Bile salt structural effect on the thermodynamic properties of a catanionic mixed adsorbed monolayer

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Abstract

The interfacial effects of two bile salts (sodium deoxycholate (NaDC) and sodium dehydrocholate (NaDHC)) in a catanionic mixed adsorbed monolayer have been investigated at 25 °C. The surfactant interfacial composition, the interfacial orientation of the molecules and the energy changes are analysed to show a thermodynamic evidence of the hydrophobic BSs effect during its intercalation into interfacial adsorbed didodecyldimethyl ammonium bromide (DDAB) molecules. Both mixed systems (NaDC–DDAB and NaDHC–DDAB) have analogous adsorption efficiencies, which are similar from a pure DDAB monolayer and superior to that obtained for both bile salts molecules. Nevertheless, their adsorption effectiveness is different: NaDC causes an increment of Γ while NaDHC produces the opposite effect. The adsorption efficiency in surface tension reduction is due to the existence of interfacial synergistic interactions (confirmed by the analysis of β γ and ΔG ad 0 values). Maximum synergistic interaction is seen for α BSs = 0.4. The hydrophobic steroid backbone of NaDHC molecule presents a deep interfacial penetration than NaDC. This fact causes a great disturbance of DDAB hydrocarbon tails and conduces to a large separation of molecules (high A m values) which explains the reduction of adsorption effectiveness (low Γ m values).

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Acknowledgements

The authors acknowledge the financial support from the Universidad Nacional del Sur, Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) and Concejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina (CONICET). PM is an adjunct researcher of (CONICET). MFL has a fellowship of the CONICET.

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  1. Departamento de Química, Universidad Nacional del Sur, CONICET-INQUISUR, 8000, Bahía Blanca, Argentina

    Marcos D. Fernández-Leyes, Paula V. Messina & Pablo C. Schulz

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  1. Marcos D. Fernández-Leyes
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  2. Paula V. Messina
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  3. Pablo C. Schulz
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Correspondence to Paula V. Messina.

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Fernández-Leyes, M.D., Messina, P.V. & Schulz, P.C. Bile salt structural effect on the thermodynamic properties of a catanionic mixed adsorbed monolayer. Colloid Polym Sci 289, 179–191 (2011). https://doi.org/10.1007/s00396-010-2336-1

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  • DOI: https://doi.org/10.1007/s00396-010-2336-1

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