Colloid and Polymer Science

, Volume 288, Issue 8, pp 893–899 | Cite as

Preparation and physicochemical characterization of novel chlorambucil-loaded nanoparticles of poly(butylcyanoacrylate)

  • Georgi G. Yordanov
  • Zorka A. Bedzhova
  • Ceco D. Dushkin
Short Communication

Abstract

The aim of the present study is the preparation and physicochemical characterization of chlorambucil-loaded poly(butylcyanoacrylate) nanoparticles. Chlorambucil is a lipophilic drug, which is used clinically against chronic lymphocytic leukemia, lymphomas, and other types of malignant diseases. However, the chlorambucil use is limited by its chemical instability and toxic side effects. A promising approach to circumvent these drawbacks is the entrapment of chlorambucil in a suitable nanosized carrier. Toward this goal, poly(butylcyanoacrylate) nanoparticles meet the requirements for a drug carrier system due to their biocompatibility, biodegradability, low toxicity, and ability to overcome the multidrug resistance in cancer cells. We prepared chlorambucil-loaded poly(butylcyanoacrylate) nanoparticles, which are characterized for chemical composition, particle size, drug content, and drug release. It is expected that the utilization of poly(butylcyanoacrylate) nanoparticles as a drug carrier system will pave the way toward more effective use of chlorambucil in the treatment of cancer.

Keywords

Poly(butylcyanoacrylate) Nanoparticles Chlorambucil Emulsion polymerization 

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Georgi G. Yordanov
    • 1
  • Zorka A. Bedzhova
    • 1
  • Ceco D. Dushkin
    • 1
  1. 1.Laboratory of Nanoparticle Science and Technology, Department of General and Inorganic Chemistry, Faculty of ChemistryUniversity of SofiaSofiaBulgaria

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