Colloid and Polymer Science

, Volume 285, Issue 13, pp 1433–1439 | Cite as

Thermoresponsive polymeric nanoparticles stabilized by surfactants

  • Čestmír KoňákEmail author
  • Jiří Pánek
  • Martin Hrubý
Original Contribution


Solutions of poly(N-isopropylacrylamide) (PNIPA) with ionic and nonionic surfactants were investigated by light scattering methods at temperatures 15–45 °C. In contrast to previous studies, where surfactants were used in excess, lower concentrations of surfactants were used. The formation of well-defined nanoparticles of PNIPA was observed on heating above the lower critical solution temperature. The effect of PNIPA and surfactant concentrations, and molecular weight of PNIPA on nanoparticle parameters and on the phase transition temperature of PNIPA solutions were investigated. An interpretation based on stabilization of PNIPA nuclei by surfactants was suggested.


Light scattering Nanoparticles Particle nucleation Poly(N-isopropylacrylamide) Surfactants 



Financial support of the Grant Agency of the Academy of Sciences of the Czech Republic (grants A100500501) is gratefully acknowledged.


  1. 1.
    Hoffman AS (1997) Intelligent polymers. In: Park K (ed) Controlled drug delivery. ACS Publications, Washington, pp 485–502Google Scholar
  2. 2.
    Neony B, Kim SW, Bae YH (2002) Drug Deliv Rev 54:37CrossRefGoogle Scholar
  3. 3.
    Oupický D, Diwadkar V (2003) Curr Opin Mol Ther 5:345Google Scholar
  4. 4.
    Taylor LD, Cerenkowski LD (1975) J Polym Sci 13:2551Google Scholar
  5. 5.
    Saiyto S, Konno M, Inomata H (1993) Adv Polym Sci 109:207Google Scholar
  6. 6.
    Wang X, Wu C (1999) Macromolecules 32:4299CrossRefGoogle Scholar
  7. 7.
    Oupický D, Reschel T, Koňák Č, Oupická L (2003) Macromolecules 36:686CrossRefGoogle Scholar
  8. 8.
    Koňák Č, Hrubý M (2006) Macromol Rapid Commun 27:877CrossRefGoogle Scholar
  9. 9.
    Eliasaff J, Silberberg A (1959) J Polym Sci 41:33CrossRefGoogle Scholar
  10. 10.
    Makhaeva EE, Tenhu H, Khokhlov AR (1998) Macromolecules 31:6112CrossRefGoogle Scholar
  11. 11.
    Ricka J, Meewes M, Nyffenegger R, Binkert T (1990) Phys Rev Lett 65:657CrossRefGoogle Scholar
  12. 12.
    Meewes M, Ricka J, de Silva M, Nyffenegger R, Binkert T (1991) Macromolecules 24:5811CrossRefGoogle Scholar
  13. 13.
    Walter R, Ricka J, Quellet Ch, Nyffenegger R, Binkert T (1996) Macromolecules 29:4019CrossRefGoogle Scholar
  14. 14.
    Wu C, Zhou S (1996) J Polym Sci, Part B: Polym Phys 34:1597CrossRefGoogle Scholar
  15. 15.
    Hunter R (1987) Foundations of Colloid Science, Clarendon, Oxford, Chapter 10Google Scholar
  16. 16.
    Dautzenberg H, Rother G (1992) Makromol Chem, Macromol Symp 61:94Google Scholar
  17. 17.
    Dautzenberg H, Rother G (1998) J Polym Sci Part B: Polym Phys 26:353CrossRefGoogle Scholar
  18. 18.
    Koňák Č, Reschel T, Oupický D, Ulbrich K (2002) Langmuir 18:8217CrossRefGoogle Scholar
  19. 19.
    Jakeš J (1995) Collect Czechoslov Chem Commun 60:1781CrossRefGoogle Scholar
  20. 20.
    Štěpánek P (1993) In: Brown W (ed) Dynamic light scattering. Clarendon, Oxford, pp 177Google Scholar
  21. 21.
    Heskins M, Guillet J (1968) J Macromol Sci Chem, Part A 2:1441CrossRefGoogle Scholar
  22. 22.
    Schild HG, Tirrell D (1991) Langmuir 7:665CrossRefGoogle Scholar
  23. 23.
    Schild HG, Tirrell D (1989) Polym Prepr 30:350Google Scholar
  24. 24.
    Cahn JW (1956) Acta Metall 4:449CrossRefGoogle Scholar
  25. 25.
    Christian JW (1981) The theory of transformations in metals and alloys, Part I. Pergamon, New YorkGoogle Scholar
  26. 26.
    Dai S, Tam KC (2004) Langmuir 20:2177CrossRefGoogle Scholar
  27. 27.
    Hsu Y-H, Chiang W-H, Chen M-C, Chern C-S, Chiu H-C (2006) Langmuir 22:6764CrossRefGoogle Scholar
  28. 28.
    Kabir-ud-Din, Sinddiqui US, Kumar S, Dar AA (2006) Colloid Polym Sci 284:807CrossRefGoogle Scholar
  29. 29.
    Koopal LK, Goloub TP, Davis TA (2004) J Colloid Interface Sci 275:360CrossRefGoogle Scholar
  30. 30.
    Gente G, Iovina A, la Mesa C (2004) J Colloid Interface Sci 274:458CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Čestmír Koňák
    • 1
    Email author
  • Jiří Pánek
    • 1
  • Martin Hrubý
    • 1
  1. 1.Institute of Macromolecular ChemistryAcademy of Sciences of the Czech RepublicPrague 6Czech Republic

Personalised recommendations