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Caveolin-1/-3: therapeutic targets for myocardial ischemia/reperfusion injury

  • Yang Yang
  • Zhiqiang Ma
  • Wei Hu
  • Dongjin Wang
  • Shuai Jiang
  • Chongxi Fan
  • Shouyin Di
  • Dong Liu
  • Yang Sun
  • Wei Yi
Review

Abstract

Myocardial ischemia/reperfusion (I/R) injury is a major cause of morbidity and mortality worldwide. Caveolae, caveolin-1 (Cav-1), and caveolin-3 (Cav-3) are essential for the protective effects of conditioning against myocardial I/R injury. Caveolins are membrane-bound scaffolding proteins that compartmentalize and modulate signal transduction. In this review, we introduce caveolae and caveolins and briefly describe the interactions of caveolins in the cardiovascular diseases. We also review the roles of Cav-1/-3 in protection against myocardial ischemia and I/R injury, and in conditioning. Finally, we suggest several potential research avenues that may be of interest to clinicians and basic scientists. The information included, herein, is potentially useful for the design of future studies and should advance the investigation of caveolins as therapeutic targets.

Keywords

Myocardial ischemia Caveolins Cardioprotection 

Abbreviations

Akt

Protein kinase B

APC

Anesthetic preconditioning

Cav

Caveolin

CSD

Caveolin scaffolding domain

eNOS

Endothelial nitric oxide synthase

ERK1/2

Extracellular signal-regulated kinases 1 and 2

GPCRs

G protein-coupled receptors

GSK3β

Glycogen synthase kinase-3β

HO-1

Heme oxygenase-1

IPC

Ischemic preconditioning

IPTC

Ischemic postconditioning

I/R

Ischemia/reperfusion

KO

Knockout

MAPKs

Mitogen-activated protein kinases

mPTP

Mitochondrial permeability transition pore

OE

Overexpression

PI3K

Phosphoinositide-3 kinase

PKC

Protein kinase C

RISK

Reperfusion injury salvage kinase

SAFE

Survivor activating factor enhancement

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Yang Yang
    • 1
    • 2
    • 3
  • Zhiqiang Ma
    • 4
  • Wei Hu
    • 2
  • Dongjin Wang
    • 3
  • Shuai Jiang
    • 5
  • Chongxi Fan
    • 4
  • Shouyin Di
    • 4
  • Dong Liu
    • 6
  • Yang Sun
    • 7
  • Wei Yi
    • 1
  1. 1.Department of Cardiovascular Surgery, Xijing HospitalThe Fourth Military Medical UniversityXi’anChina
  2. 2.Department of Biomedical EngineeringThe Fourth Military Medical UniversityXi’anChina
  3. 3.Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower HospitalNanjing University Medical SchoolNanjingChina
  4. 4.Department of Thoracic Surgery, Tangdu HospitalThe Fourth Military Medical UniversityXi’anChina
  5. 5.Department of Aerospace MedicineThe Fourth Military Medical UniversityXi’anChina
  6. 6.State Key Laboratory of Cardiovascular Disease, Fuwai HospitalNational Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical CollegeBeijingChina
  7. 7.Department of Geriatrics, Xijing HospitalThe Fourth Military Medical UniversityXi’anChina

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