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Novel aspects of excitation–contraction coupling in heart failure

  • Stefan Neef
  • Lars S. MaierEmail author
Invited Review
Part of the following topical collections:
  1. Novel Perspectives on Heart Failure

Abstract

Excitation–contraction coupling is the process by which electrical activation is translated into contraction of a cardiac myocyte and thus the heart. In heart failure, expression, phosphorylation, and function of several intracellular proteins that are involved in excitation–contraction coupling are altered. The present review article summarizes central principles and highlights novel aspects of alterations in heart failure, focusing especially on recent findings regarding altered sarcoplasmic reticulum Ca2+-leak and late Na+-current without being able to cover all changes in full detail. These two pathomechanisms seem to play interesting roles with respect to systolic and diastolic dysfunction and may also be important for cardiac arrhythmias. Furthermore, the article outlines the translation of these novel findings into potential therapeutic approaches.

Keywords

Calcium Calcium/calmodulin-dependent protein kinase II (CaMKII) Late sodium current (late INaProtein kinase A (PKA) Sarcoplasmic reticulum (SR) Sodium SR calcium leak 

Notes

Acknowledgments

Dr. Maier is funded by Deutsche Forschungsgemeinschaft (DFG) grant MA 1982/4-2, TPA03 SFB 1002, GRK 1816 RP3, the DZHK (Deutsches Zentrum für Herz-Kreislauf-Forschung), and the Fondation Leducq ‘Alliance for CaMKII Signaling in Heart’ as well as ‘Redox and Nitrosative Regulation of Cardiac Remodeling’.

Conflict of interest

Dr. Maier acknowledges research grants and funding from CVT, GILEAD, and MENARINI/Berlin-Chemie as well as speaker honoraria from Berlin-Chemie.

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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Abt. Kardiologie und Pneumologie/HerzzentrumGeorg-August-Universität GöttingenGöttingenGermany

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