Basic Research in Cardiology

, Volume 103, Issue 1, pp 1–11 | Cite as

Autoantibody-mediated cardiac arrhythmias: mechanisms and clinical implications

  • Pietro Enea Lazzerini
  • Pier Leopoldo Capecchi
  • Francesca Guideri
  • Maurizio Acampa
  • Enrico Selvi
  • Stefania Bisogno
  • Mauro Galeazzi
  • Franco Laghi-Pasini
REVIEW

Abstract

Cardiac arrhythmias, including conduction defects and tach- yarrhythmias, represent an important source of morbidity and mortality in industrialized countries. Among the different pathophysiological mechanisms involved in the arrhythmogenesis, an inappropriate activation of the immune system represents a field of recent increasing interest. In fact, a large amount of studies suggest that specific autoantibody may be significantly involved in the pathogenesis of cardiac arrhythmias not only in the course of systemic autoimmune disease, but also in a number of rhythm disorders currently classified as “idiopathic.” Although the strongest evidence concerns the relationship between anti-Ro/SSA antibodies and the development of congenital heart block in foetus and newborn, other specific autoantibodies demonstrated the aptitude to affect directly the myocardial tissue, thus producing interference in its bioelectric activity thereby leading to rhythm disorders, also life-threatening. The identification of an immunological autoantibody-mediated mechanism opens new perspectives in the treatment and prevention of cardiac arrhythmias in such patients, including the use of immunosuppressive agents and/or the removal of autoantibodies by immuno-adsorption technique.

Key words

arrhythmias conduction defects autoimmunity autoantibodies anti-Ro/SSA 

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Copyright information

© Springer 2007

Authors and Affiliations

  • Pietro Enea Lazzerini
    • 1
  • Pier Leopoldo Capecchi
    • 1
  • Francesca Guideri
    • 1
  • Maurizio Acampa
    • 2
  • Enrico Selvi
    • 3
  • Stefania Bisogno
    • 3
  • Mauro Galeazzi
    • 3
  • Franco Laghi-Pasini
    • 1
  1. 1.Dept. of Clinical Medicine and Immunological Sciences, Division of Clinical ImmunologyUniversity of SienaSienaItaly
  2. 2.Division of Internal MedicineUniversity of SienaSienaItaly
  3. 3.Division of RheumatologyUniversity of SienaSienaItaly

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