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Basic Research in Cardiology

, Volume 101, Issue 2, pp 190–191 | Cite as

A really radical observation

A comment on Penna et al. in Basic Res Cardiol (2006) 101:180–189
  • James M. Downey
  • Michael V. Cohen
EDITORIAL

Keywords

Public Health Radical Observation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    Costa ADT, Garlid KD, West IC, Lincoln TM, Downey JM, Cohen MV, Critz SD (2005) Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria. Circ Res 97:329–336CrossRefPubMedGoogle Scholar
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    Forbes RA, Steenbergen C, Murphy E (2001) Diazoxide-induced cardioprotection requires signaling through a redoxsensitive mechanism. Circ Res 88:802–809PubMedGoogle Scholar
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    Oldenburg O, Qin Q, Krieg T, Yang X-M, Philipp S, Critz SD, Cohen MV, Downey JM (2004) Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection. Am J Physiol 286:H468–H476Google Scholar
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    Oldenburg O, Qin Q, Sharma AR, Cohen MV, Downey JM, Benoit JN (2002) Acetylcholine leads to free radical production dependent on KATP channels, Gi proteins, phosphatidylinositol 3-kinase and tyrosine kinase. Cardiovasc Res 55:544–552PubMedGoogle Scholar
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    Pain T, Yang X-M, Critz SD, Yue Y, Nakano A, Liu GS, Heusch G, Cohen MV, Downey JM (2000) Opening of mitochondrial KATP channels triggers the preconditioned state by generating free radicals. Circ Res 87:460–466PubMedGoogle Scholar
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    Tritto I, D’Andrea D, Eramo N, Scognamiglio A, De Simone C, Violante A, Esposito A, Chiariello M, Ambrosio G (1997) Oxygen radicals can induce preconditioning in rabbit hearts. Circ Res 80:743–748PubMedGoogle Scholar
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    Yang X-M, Proctor JB, Cui L, Krieg T, Downey JM, Cohen MV (2004) Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways. J Am Coll Cardiol 44:1103–1110CrossRefPubMedGoogle Scholar
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    Yao Z, Tong J, Tan X, Li C, Shao Z, Kim WC, Vanden Hoek TL, Becker LB, Head CA, Schumacker PT (1999) Role of reactive oxygen species in acetylcholineinduced preconditioning in cardiomyocytes. Am J Physiol 277:H2504–H2509PubMedGoogle Scholar

Copyright information

© Steinkopff-Verlag 2006

Authors and Affiliations

  • James M. Downey
    • 1
    • 2
  • Michael V. Cohen
    • 2
  1. 1.Department of PhysiologyUniversity of South Alabama, College of MedicineMobile, ALUSA
  2. 2.Department of MedicineUniversity of South Alabama, College of Medicine Mobile, ALUSA

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