A single dose of purple grape juice improves physical performance and antioxidant activity in runners: a randomized, crossover, double-blind, placebo study



To investigate the effects of a single dose of juice on physical performance, oxidative stress, inflammation and muscle damage in runners.


Fourteen recreational male runners (39 ± 9 years, VO2peak = 55.9 ± 6.5 ml/kg/min) performed two running tests to exhaustion at 80% of VO2max after ingesting grape juice or a placebo drink (10 ml/kg/day) randomly. Blood samples were taken before and 2 h after supplementation and immediately after running to analyze total antioxidant capacity (TAC), malondialdehyde (MDA), alpha-1 acid glycoprotein (A1GPA), high-sensitivity C-reactive protein (hs-CRP), creatine kinase (CK) and lactate dehydrogenase (LDH).


The participants ran for an average of 59.2 ± 27.8 min until exhaustion in the placebo group and for 68.4 ± 29.7 min until exhaustion in the grape juice intake group, which was a significantly longer time (p = 0.008). This improvement in physical performance was accompanied by a 43.6% increase in TAC (p = 0.000) at the post-exercise timepoint compared to the level at baseline. MDA, A1GPA, hs-CRP, CK, and LDH did not exhibit changes. In contrast, no significant change in any variable was observed after consuming the placebo drink.


The single-dose intake of purple grape juice demonstrated an ergogenic effect in recreational runners by increasing run time to exhaustion and increasing antioxidant activity.

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The authors thank the Coordination for the Improvement of Higher Education Personnel level (CAPES) and the National Council for Scientific and Technological Development (CNPq) for the support and encouragement of this research. The authors also thank the Instituto Brasileiro do Vinho (IBRAVIN) together with the Government of the State of Rio Grande do Sul, with funds from the Agriculture Secretariat of Rio Grande do Sul, for supporting the execution of this work.

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Correspondence to Alexandre Sérgio Silva.

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de Lima Tavares Toscano, L., Silva, A.S., de França, A.C.L. et al. A single dose of purple grape juice improves physical performance and antioxidant activity in runners: a randomized, crossover, double-blind, placebo study. Eur J Nutr (2019) doi:10.1007/s00394-019-02139-6

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  • Polyphenols
  • Ergogenic substances
  • Sports nutrition
  • Athletic performance
  • Oxidative stress