Activation of T-regulatory cells by a synbiotic may be important for its anti-inflammatory effect
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We read with great interest Moser and colleagues’ paper entitled “Effects of an oral synbiotic on the gastrointestinal immune system and microbiota in patients with diarrhea-predominant irritable bowel syndrome” published in your journal . The results showed that the synbiotic reduced the symptoms of irritable bowel syndrome (IBS) with increased microbiota diversity and decreased inflammatory status. The synbiotic increased butyrate, a key anti-inflammatory metabolite produced by intestinal commensal bacteria and decreased zonulin, an indicator of intestinal permeability. However, regulatory T-cells (T-Reg cells) changes by the synbiotic were not observed in this study although CD4 T-cells were significantly decreased. As activation of T-Reg cells by butyrate plays a key role in the intestinal inflammatory status , it would be interesting to further investigate the reasons as to why they were not altered in this study. We think that this may be related with a pre-existing...
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