European Journal of Nutrition

, Volume 58, Issue 8, pp 3379–3380 | Cite as

Activation of T-regulatory cells by a synbiotic may be important for its anti-inflammatory effect

  • Jiezhong Chen
  • Luis VitettaEmail author
Letter to the Editor

We read with great interest Moser and colleagues’ paper entitled “Effects of an oral synbiotic on the gastrointestinal immune system and microbiota in patients with diarrhea-predominant irritable bowel syndrome” published in your journal [1]. The results showed that the synbiotic reduced the symptoms of irritable bowel syndrome (IBS) with increased microbiota diversity and decreased inflammatory status. The synbiotic increased butyrate, a key anti-inflammatory metabolite produced by intestinal commensal bacteria and decreased zonulin, an indicator of intestinal permeability. However, regulatory T-cells (T-Reg cells) changes by the synbiotic were not observed in this study although CD4 T-cells were significantly decreased. As activation of T-Reg cells by butyrate plays a key role in the intestinal inflammatory status [2], it would be interesting to further investigate the reasons as to why they were not altered in this study. We think that this may be related with a pre-existing...


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Medlab Clinical LtdSydneyAustralia
  2. 2.Faculty of Medicine and HealthThe University of SydneySydneyAustralia

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