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Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study

  • Nerea Becerra-Tomás
  • Guillermo Mena-Sánchez
  • Andrés Díaz-López
  • Miguel Ángel Martínez-González
  • Nancy Babio
  • Dolores Corella
  • Gala Freixer
  • Dora Romaguera
  • Jesús Vioque
  • Ángel M. Alonso-Gómez
  • Julia Wärnberg
  • J. Alfredo Martínez
  • Lluís Serra-Majem
  • Ramon Estruch
  • José Carlos Fernández-García
  • José Lapetra
  • Xavier Pintó
  • Josep A. Tur
  • José López-Miranda
  • Aurora Bueno-Cavanillas
  • José Juan Gaforio
  • Pilar Matía-Martín
  • Lidia Daimiel
  • Vicente Martín-Sánchez
  • Josep Vidal
  • Clotilde Vázquez
  • Emili Ros
  • Cristina Razquin
  • Iván Abellán Cano
  • Jose V. Sorli
  • Laura Torres
  • Marga Morey
  • Eva Mª Navarrete-Muñoz
  • Lucas Tojal Sierra
  • Edelys Crespo-Oliva
  • M. Ángeles Zulet
  • Almudena Sanchez-Villegas
  • Rosa Casas
  • M. Rosa Bernal-Lopez
  • José Manuel Santos-Lozano
  • Emili Corbella
  • Maria del Mar Bibiloni
  • Miguel Ruiz-Canela
  • Rebeca Fernández-Carrión
  • Mireia Quifer
  • Rafel M. Prieto
  • Noelia Fernandez-Brufal
  • Itziar Salaverria Lete
  • Juan Carlos Cenoz
  • Regina Llimona
  • Jordi Salas-SalvadóEmail author
  • The PREDIMED-Plus Investigators
Original Contribution

Abstract

Purpose

To assess the association between the consumption of non-soy legumes and different subtypes of non-soy legumes and serum uric acid (SUA) or hyperuricemia in elderly individuals with overweight or obesity and metabolic syndrome.

Methods

A cross-sectional analysis was conducted in the framework of the PREDIMED-Plus study. We included 6329 participants with information on non-soy legume consumption and SUA levels. Non-soy legume consumption was estimated using a semi-quantitative food frequency questionnaire. Linear regression models and Cox regression models were used to assess the associations between tertiles of non-soy legume consumption, different subtypes of non-soy legume consumption and SUA levels or hyperuricemia prevalence, respectively.

Results

Individuals in the highest tertile (T3) of total non-soy legume, lentil and pea consumption, had 0.14 mg/dL, 0.19 mg/dL and 0.12 mg/dL lower SUA levels, respectively, compared to those in the lowest tertile (T1), which was considered the reference one. Chickpea and dry bean consumption showed no association. In multivariable models, participants located in the top tertile of total non-soy legumes [prevalence ratio (PR): 0.89; 95% CI 0.82–0.97; p trend = 0.01, lentils (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01), dry beans (PR: 0.91; 95% C: 0.84–0.99; p trend = 0.03) and peas (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01)] presented a lower prevalence of hyperuricemia (vs. the bottom tertile). Chickpea consumption was not associated with hyperuricemia prevalence.

Conclusions

In this study of elderly subjects with metabolic syndrome, we observed that despite being a purine-rich food, non-soy legumes were inversely associated with SUA levels and hyperuricemia prevalence.

Trial registration

ISRCTN89898870. Registration date: 24 July 2014.

Keywords

Serum uric acid Hyperuricemia Non-soy legumes PREDIMED-Plus 

Notes

Acknowledgements

The authors especially thank the PREDIMED-Plus participants for their enthusiastic collaboration, the PREDIMED-Plus personnel for their outstanding support, and the personnel of all associated primary care centers for their exceptional effort. CIBEROBN, CIBERESP and CIBERDEM are initiatives of Instituto de Salud Carlos III, Spain. We thank the PREDIMED-Plus Biobank Network, part of the National Biobank Platform of Instituto de Salud Carlos III for storing and managing biological samples. List of PREDIMED-Plus study investigators; Steering Committee: J. Salas-Salvadó (Coordinator), M.A. Martínez-González, M. Fitó. E. Ros, FJ. Tinahones, D. Corella and R. Estruch. Executive Committee: J. Salas-Salvadó, M.A. Martínez-González, D. Corella, M. Fitó, J. Vioque, D. Romaguera, J.A Martínez, J. Wärnberg, J. Lopez-Miranda, R. Estruch, A. Bueno-Cavanillas, Á.M. Alonso-Gómez, J.A. Tur, FJ. Tinahones, L. Serra-Majem, V. Martin, J. Lapetra, C. Vázquez, X. Pinto, J. Vidal, L. Daimiel, M. Delgado-Rodríguez, M.A. Rubio and E. Ros. Dietary and Lifestyle Intervention Committee: J. Salas-Salvadó (chair), M.A. Martínez-González, M. Fitó and R. Estruch; Dietary Intervention: J. Salas-Salvadó (chair), N. Babio, E. Ros, A. Sánchez-Tainta; Physical Exercise: M. Fitó (chair), H. Schröder, A. Marcos, D. Corella, J. Warnberg; Behavioural support: R. Estruch (chair), F. Fernández-Aranda, C. Botella and J. Salas-Salvadó. Clinical Event Ascertainment Committee: F. Arós (Chair), M. Aldamiz, A. Alonso-Gómez, L. Forga, A. García-Layana, J. Portu, J. Timiraos, A. González-Pinto, I. Zorrilla, M. Martínez-Kareaga, P. Seoane. Chair: Dr. Fernando Arós Cardiology: Dr. Angel Alonso-Gómez; Dr. Fernando Arós Neurology: Dr. Juan Timiraos Internal Medicine: Dr. Mikel Aldamiz; Dr. Joseba Portu Endocrinology: Dr. Lluis Forga Ophthalmology: Dr. Alfredo García-Layana Psychiatry: Dr. Ana González Pinto; Dr. Iñaki Zorrilla Oncology: Dr. Mireia Martínez; Dr. Patricia Seoane Independent Data and Safety Monitoring Board: M.J. Stampfer (Harvard School of Public Health), J. Sabate (Loma Linda University), A. Astrup (Copenhagen University), F. Fernandez-Aviles (Universidad Complutense of Madrid), X. Pi-Sunyer (Columbia University). Support groups: C. Botella, F. Fernandez-Aranda, R. Lamuela, A. Marcos, M. del Puy Portillo, E. Ros, G. Sáez, F. Arós, E. Gómez-Gracia Rovira i Virgili University, Department of Biochemistry and Biotechnology, Human Nutrition Unit, University Hospital of Sant Joan de Reus, Pere Virgili Institute for Health Research, Reus, Spain: R. Pedret Llaberia, R. Gonzalez, R. Sagarra Álamo, F. 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González Cerrajero, M.A. Rubio Herrera, M. Torrego Ellacuría, A. Barabash Bustelo, M. Ortiz Ramos, U. Garin Barrutia. Department of Basic and Clinical Psychology and Psychobiology, University Jaume I, Castellón de la Plana, Spain: R. Baños, A. García-Palacios. Oxidative Pathology Unit. Department of Biochemistry and Molecular Biology, School of Medicine-INCLIVA, Service of Clinical Analyses, University Hospital Doctor Peset, Valencia, Spain. University of Valencia, Valencia Spain: G. Sáez Tormo (Sáez GT), N. Estañ-Capell, A. Iradi Casal, L. Monzó Beltrán, M. Fandos Sánchez, E. Alonso Iglesias, D. Acevedo León, A. Hernando Espinilla, A. Mora Herranz, C. Cerdá Micó. Department of Preventive Medicine, University of Malaga, Malaga, Spain: J. Fernández-Crehuet Navajas, M. Gutiérrez Bedmar, A. García Rodriguez, A. Mariscal Larrubia, M. Carnero Varo, C. Muñoz Bravo. Department of Psychiatry, University Hospital of Bellvitge, Barcelona, Spain: F. Fernández-Aranda, S. Jiménez-Murcia, N. Mallorqui-Bagué, R. Granero, Z. Agüera, M. Lozano-Madrid.

Funding

The PREDIMED-Plus trial was supported by the official funding agency for biomedical research of the Spanish government, ISCIII, through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated FIS projects led by J.S.-S. and J.Vid., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, and PI17/00926), the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., the European Research Council (Advanced Research Grant 2013–2018, 340918) to M.Á.M.-G., the Recercaixa Grant to J.S.-S. (2013ACUP00194), Grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a Grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN Grant, and funds from the European Regional Development Fund (CB06/03). O.C. is supported by ISCIII Grant JR17/00022. M Rosa Bernal-Lopez was supported by “Miguel Servet Type I” program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest related to this article.

Ethical standards

All participants provided written informed consent, and the study protocol and procedures were approved according to the ethical standards of the Declaration of Helsinki by all the participating institutions.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Nerea Becerra-Tomás
    • 1
    • 2
    • 3
    • 4
  • Guillermo Mena-Sánchez
    • 1
    • 2
    • 3
    • 4
  • Andrés Díaz-López
    • 1
    • 2
    • 3
    • 4
  • Miguel Ángel Martínez-González
    • 3
    • 5
    • 6
  • Nancy Babio
    • 1
    • 2
    • 3
    • 4
  • Dolores Corella
    • 3
    • 7
  • Gala Freixer
    • 8
  • Dora Romaguera
    • 3
    • 9
  • Jesús Vioque
    • 10
    • 11
  • Ángel M. Alonso-Gómez
    • 3
    • 12
  • Julia Wärnberg
    • 3
    • 13
  • J. Alfredo Martínez
    • 3
    • 14
    • 15
  • Lluís Serra-Majem
    • 3
    • 16
  • Ramon Estruch
    • 3
    • 17
  • José Carlos Fernández-García
    • 3
    • 18
  • José Lapetra
    • 3
    • 19
  • Xavier Pintó
    • 3
    • 20
  • Josep A. Tur
    • 3
    • 9
    • 21
  • José López-Miranda
    • 3
    • 22
  • Aurora Bueno-Cavanillas
    • 10
    • 23
  • José Juan Gaforio
    • 10
    • 24
  • Pilar Matía-Martín
    • 25
  • Lidia Daimiel
    • 15
  • Vicente Martín-Sánchez
    • 10
    • 26
  • Josep Vidal
    • 27
    • 28
  • Clotilde Vázquez
    • 3
    • 29
  • Emili Ros
    • 3
    • 30
  • Cristina Razquin
    • 3
    • 5
  • Iván Abellán Cano
    • 1
    • 31
  • Jose V. Sorli
    • 3
    • 7
  • Laura Torres
    • 8
  • Marga Morey
    • 3
    • 9
  • Eva Mª Navarrete-Muñoz
    • 10
    • 11
  • Lucas Tojal Sierra
    • 3
    • 12
  • Edelys Crespo-Oliva
    • 3
    • 13
  • M. Ángeles Zulet
    • 3
    • 14
  • Almudena Sanchez-Villegas
    • 3
    • 16
  • Rosa Casas
    • 3
    • 17
  • M. Rosa Bernal-Lopez
    • 3
    • 18
  • José Manuel Santos-Lozano
    • 3
    • 19
  • Emili Corbella
    • 3
    • 20
  • Maria del Mar Bibiloni
    • 3
    • 9
    • 21
  • Miguel Ruiz-Canela
    • 3
    • 5
  • Rebeca Fernández-Carrión
    • 3
    • 7
  • Mireia Quifer
    • 8
  • Rafel M. Prieto
    • 3
    • 9
    • 32
  • Noelia Fernandez-Brufal
    • 10
    • 11
  • Itziar Salaverria Lete
    • 12
  • Juan Carlos Cenoz
    • 5
    • 33
  • Regina Llimona
    • 8
  • Jordi Salas-Salvadó
    • 1
    • 2
    • 3
    • 4
    Email author
  • The PREDIMED-Plus Investigators
  1. 1.Unitat de Nutrició, Departament de Bioquímica i Biotecnologia, Faculty of Medicine and Health SciencesUniversitat Rovira i VirgiliReusSpain
  2. 2.Institut d’Investigació Sanitària Pere Virgili (IISPV)ReusSpain
  3. 3.Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIIMadridSpain
  4. 4.Nutrition UnitUniversity Hospital of Sant Joan de ReusReusSpain
  5. 5.Department of Preventive Medicine and Public Health, IDISNAUniversity of NavarraPamplonaSpain
  6. 6.Department of NutritionHarvard T.H. Chan School of Public HealthBostonUSA
  7. 7.Department of Preventive MedicineUniversity of ValenciaValenciaSpain
  8. 8.Cardiovascular Risk and Nutrition research group (CARIN)Hospital del Mar Research Institute (IMIM)BarcelonaSpain
  9. 9.Health Research Institute of the Balearic Islands (IdISBa)PalmaSpain
  10. 10.CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos IIIMadridSpain
  11. 11.Miguel Hernandez University, ISABIAL-FISABIOAlicanteSpain
  12. 12.Department of Cardiology, Organización Sanitaria Integrada (OSI) ARABAUniversity Hospital ArabaVitoria-GasteizSpain
  13. 13.Department of Nursing, School of Health SciencesUniversity of Málaga-Institute of Biomedical Research in Malaga (IBIMA)MálagaSpain
  14. 14.Department of Nutrition, Food Science and Physiology, IDISNAUniversity of NavarraPamplonaSpain
  15. 15.Precision Nutrition Program, IMDEA Food, CEI UAM + CSICMadridSpain
  16. 16.Research Institute of Biomedical and Health Sciences (IUIBS), Preventive Medicine Service, Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health ServiceUniversity of Las Palmas de Gran CanariaLas PalmasSpain
  17. 17.Department of Internal Medicine, IDIBAPS, Hospital ClinicUniversity of BarcelonaBarcelonaSpain
  18. 18.Internal Medicine Department. Regional University Hospital of Málaga. Instituto de Investigación Biomédica de Málaga (IBIMA)University of MálagaMálagaSpain
  19. 19.Department of Family Medicine, Research UnitSevilleSpain
  20. 20.Lipids and Vascular Risk Unit, Internal MedicineHospital Universitario de BellvitgeBarcelonaSpain
  21. 21.Research Group on Community Nutrition and Oxidative StressUniversity of Balearic IslandsPalma de MallorcaSpain
  22. 22.Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University HospitalUniversity of CordobaCórdobaSpain
  23. 23.Instituto de Investigación Biosanitaria ibs.GRANADA and Department of Preventive MedicineUniversity of GranadaGranadaSpain
  24. 24.Department of Health Sciences and Center for Advanced Studies in Olive Grove and Olive OilsUniversity of JaénJaénSpain
  25. 25.Department of Endocrinology and NutritionInstituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC)MadridSpain
  26. 26.Institute of Biomedicine (IBIOMED)University of LeónLeónSpain
  27. 27.CIBER Diabetes y Enfermedades Metabólicas (CIBERDEM)Instituto de Salud Carlos III (ISCIII)MadridSpain
  28. 28.Departament of Endocrinology, IDIBAPS, Hospital ClínicUniversity of BarcelonaBarcelonaSpain
  29. 29.Department of EndocrinologyFundación Jiménez-DíazMadridSpain
  30. 30.Lipid Clinic, Department of Endocrinology and NutritionInstitut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital ClínicBarcelonaSpain
  31. 31.Hospital Universitario Joan XXIII Tarragona-CAP Horts de Miró ReusTarragonaSpain
  32. 32.Laboratory of Renal Lithiasis ResearchUniversity Institute of Health Sciences Research (IUNICS), University of Balearic IslandsPalma de MallorcaSpain
  33. 33.Servicio Navarro de Salud-OsasunbideaPamplonaSpain

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