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Selenium and large artery structure and function: a 10-year prospective study

  • R. Swart
  • A. E. Schutte
  • J. M. van Rooyen
  • Catharina M. C. Mels
Original Contribution
  • 3 Downloads

Abstract

Purpose

Despite selenium’s beneficial effects in counteracting oxidative stress, inflammation, and vascular endothelial dysfunction, controversial results exist regarding the long-term associations between selenium and atherosclerosis, arterial stiffness, and hypertension. We investigated in normal and selenium-deficient groups (and the total group), whether serum selenium relates to measures of large artery structure and function over 10 years.

Methods

This longitudinal study included black adults from rural and urban areas in South Africa. Serum selenium and blood pressure were measured at baseline (N = 987). At follow-up, carotid intima media thickness (IMT), cross-sectional wall area (CSWA), carotid-femoral pulse wave velocity (c-fPWV), and blood pressure were measured (N = 718). Selenium deficiency was classified as serum levels < 8 µg/100 ml.

Results

In multivariable-adjusted regression analyses performed in the normal selenium group, c-fPWV after 10 years was negatively associated with baseline selenium (β = − 0.09; p = 0.016). In the normal selenium group, baseline (but not 10 years) blood pressure also associated negatively with baseline selenium (β = − 0.09; p = 0.007). Both IMT (β = 0.12; p = 0.001) and CSWA (β = 0.10; p = 0.003) after 10 years associated positively with baseline selenium in the total, normal, and selenium-deficient groups.

Conclusion

We found a long-term vascular protective association of selenium on arterial stiffness and blood pressure in Africans with normal selenium levels, supporting the notion that selenium fulfills a vascular protective role. In contrast, we found a potential detrimental association between selenium and carotid wall thickness, particularly evident in individuals within the highest quartile of serum selenium.

Keywords

Carotid intima media thickness Atherosclerosis Pulse wave velocity Arterial stiffness Blood pressure Micronutrient 

Notes

Acknowledgements

We would like to thank all the participants, students, and supporting staff of the PURE study and particularly: (1) PURE-SA research team, field workers, and office staff at the North-West University, South Africa. (2) PURE-International: The PURE project office staff at the Population Health Research Institute (PHRI), Hamilton Health Sciences, and McMaster University, ON, Canada.

Author contributions

RS was responsible for the planning, writing, and composition of the manuscript as well as the statistical analyses. CMCM, AES, and JMvR gave recommendations for the framework, writing, and composition of the manuscript as well as the methodology. They also supervised the statistical analyses and helped with the formulation of the tables and figures.

Funding

This project was funded by the South African Netherlands Research Programme on Alternatives in Development, North-West University, Population Health Research Institute, Roche Diagnostics (South Africa) and South African Medical Research Council, South African National Research Foundation (NRF), and South African Sugar Association (SASA) for the analyses (Grant number: Project 249). Opinions expressed and conclusions are those of the authors and are not necessarily to be attributed to the NRF.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interests.

Supplementary material

394_2018_1875_MOESM1_ESM.docx (21 kb)
Supplementary material 1 (DOCX 21 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • R. Swart
    • 1
  • A. E. Schutte
    • 1
    • 2
  • J. M. van Rooyen
    • 1
    • 2
  • Catharina M. C. Mels
    • 1
    • 2
  1. 1.Hypertension in Africa Research Team (HART)North-West UniversityPotchefstroomSouth Africa
  2. 2.Medical Research Council, Unit for Hypertension and Cardiovascular DiseaseNorth-West UniversityPotchefstroomSouth Africa

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