Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study
- 368 Downloads
Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study.
The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires.
During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97–1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95–1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95–1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81–0.99), but this association was based on a sub-analysis with a small number of cancer cases.
In this large prospective study, coffee and tea consumptions were not associated with TC risk.
KeywordsThyroid cancer Coffee Tea Intake Cohort EPIC
24-h dietary recall
Body mass index
European Prospective Investigation into Cancer and Nutrition
International Agency for Research on Cancer
Not otherwise specified
We thank Mr. Bertrand Hémon for his valuable help with the EPIC database. The authors also thank all participants in the EPIC cohorts for their invaluable contribution to the study.
RZ-R, SF, and SR designed the research; RZ-R, MAA, and VC performed the statistical analyses; RZ-R and MAA drafted the manuscript; SF, MA, JH, MS, KKT, EW, M-CB-R, GB, AS, AA, and SR contributed to the discussion. All authors reviewed, edited, and approved the final manuscript.
This study was supported by the Institute of Health Carlos III, Spain (CP15/00100), and cofounded by the European Regional Development Fund (ERDF) “A way to build Europe”. The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF) (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS): PI13/00061 to Granada; PI13/01162 to EPIC-Murcia, Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, AGAUR, Generalitat de Catalunya (exp. 2014 SGR 726), The Health Research Funds (RD12/0036/0018) (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (United Kingdom). RZ-R would like to thank the “Miguel Servet” program (CP15/00100) from the Institute of Health Carlos III (Spain) and the European Social Fund (ESF).
Compliance with ethical standards
Conflict of interest
Zamora-Ros R, Alghamdi MA, Cayssials V, Franceschi S, Almquist M, Hennings J, Sandström M, Tsilidis KK, Weiderpass E, Boutron-Ruault M-C, Hammer Bech B, Overvad K, Tjønneland A, Petersen KEN, Mancini FR, Mahamat-Saleh Y, Bonnet F, Kühn T, Fortner RT, Boeing H, Trichopoulou A, Bamia C, Martimianaki G, Masala G, Grioni S, Panico S, Tumino R, Fasanelli F, Skeie G, Braaten T, Lasheras C, Salamanca-Fernández E, Amiano P, Chirlaque M-D, Barricarte A, Manjer J, Wallström P, Bueno-de-Mesquita HB, Peeters PH, Khaw K-T, Wareham NJ, Schmidt JA, Aune D, Byrnes G, Scalbert A, Agudo A, and Rinaldi S have no conflict of interest.
- 5.Kitahara CM, McCullough ML, Franceschi S, Rinaldi S, Wolk A, Neta G, Olov Adami H, Anderson K, Andreotti G, Beane Freeman LE, Bernstein L, Buring JE, Clavel-Chapelon F, De Roo LA, Gao YT, Gaziano JM, Giles GG, Håkansson N, Horn-Ross PL, Kirsh VA, Linet MS, MacInnis RJ, Orsini N, Park Y, Patel AV, Purdue MP, Riboli E, Robien K, Rohan T, Sandler DP, Schairer C, Schneider AB, Sesso HD, Shu XO, Singh PN, van den Brandt PA, Ward E, Weiderpass E, White E, Xiang YB, Zeleniuch-Jacquotte A, Zheng W, Hartge P, Berrington de González A (2016) Anthropometric factors and thyroid cancer risk by histological subtype: pooled analysis of 22 prospective studies. Thyroid 26:306–318. https://doi.org/10.1089/thy.2015.0319 CrossRefPubMedPubMedCentralGoogle Scholar
- 6.Sen A, Tsilidis KK, Allen NE, Rinaldi S, Appleby PN, Almquist M, Schmidt JA, Dahm CC, Overvad K, Tjønneland A, Rostgaard-Hansen AL, Clavel-Chapelon F, Baglietto L, Boutron-Ruault MC, Kühn T, Katze VA, Boeing H, Trichopoulou A, Tsironis C, Lagiou P, Palli D, Pala V, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HA, Peeters PH, Hjartåker A, Lund E, Weiderpass E, Quirós JR, Agudo A, Sánchez MJ, Arriola L, Gavrila D, Gurrea AB, Tosovic A, Hennings J, Sandström M, Romieu I, Ferrari P, Zamora-Ros R, Khaw KT, Wareham NJ, Riboli E, Gunter M, Franceschi S (2015) Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study. Br J Cancer 113:840–847. https://doi.org/10.1038/bjc.2017.235 CrossRefPubMedPubMedCentralGoogle Scholar
- 7.Zamora-Ros R, Rinaldi S, Tsilidis KK, Weiderpass E, Boutron-Ruault MC, Rostgaard-Hansen AL, Tjønneland A, Clavel-Chapelon F, Mesrine S, Katzke VA, Kühn T, Förster J, Boeing H, Trichopoulou A, Lagiou P, Klinaki E, Masala G, Sieri S, Ricceri F, Tumino R, Mattiello A, Peeters PH, Bueno-de-Mesquita HB, Engeset D, Skeie G, Argüelles M, Agudo A, Sánchez MJ, Chirlaque MD, Barricarte A, Chamosa S, Almquist M, Tosovic A, Hennings J, Sandström M, Schmidt JA, Khaw KT, Wareham NJ, Cross AJ, Slimani N, Byrnes G, Romieu I, Riboli E, Franceschi S (2016) Energy and macronutrient intake and risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition study. Int J Cancer 138:65–73. https://doi.org/10.1002/ijc.29693 CrossRefPubMedGoogle Scholar
- 9.Zamora-Ros R, Beraud V, Franceschi S, Cayssials V, Tsilidis KK, Boutron-Ruault MC, Weiderpass E, Overvad K, Tjønneland A, Eriksen AK, Bonnet F, Affret A, Katzke V, Kühn T, Boeing H, Trichopoulou A, Valanou E, Karakatsani A, Masala G, Grioni S, Santucci de Magistris M, Tumino R, Ricceri F, Skeie G, Parr CL, Merino S, Salamanca-Fernández E, Chirlaque MD, Ardanaz E, Amiano P, Almquist M, Drake I, Hennings J, Sandström M, Bueno-de-Mesquita HBA, Peeters PH, Khaw KT, Wareham NJ, Schmidt JA, Perez-Cornago A, Aune D, Riboli E, Slimani N, Scalbert A, Romieu I, Agudo A, Rinaldi S (2018) Consumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Int J Cancer 142:449–459. https://doi.org/10.1002/ijc.30880 CrossRefPubMedGoogle Scholar
- 10.Zamora-Ros R, Castaneda J, Rinaldi S, Cayssials V, Slimani N, Weiderpass E, Tsilidis KK, Boutron-Ruault MC, Overvad K, Eriksen AK, Tjønneland A, Kühn T, Katzke V, Boeing H, Trichopoulou A, La Vecchia C, Kotanidou A, Palli D, Grioni S, Mattiello A, Tumino R, Sciannameo V, Lund E, Merino S, Salamanca-Fernández E, Amiano P, Huerta JM, Barricarte A, Ericson U, Almquist M, Hennings J, Sandström M, Bueno-de-Mesquita HB, Peeters PH, Khaw KT, Wareham NJ, Schmidt JA, Cross AJ, Riboli E, Scalbert A, Romieu I, Agudo A, Franceschi S (2017) Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. J Nutr 147:1366–1373. https://doi.org/10.3945/jn.117.247874 CrossRefPubMedGoogle Scholar
- 14.Zamora-Ros R, Knaze V, Rothwell JA, Hémon B, Moskal A, Overvad K, Tjønneland A, Kyrø C, Fagherazzi G, Boutron-Ruault MC, Touillaud M, Katzke V, Kühn T, Boeing H, Förster J, Trichopoulou A, Valanou E, Peppa E, Palli D, Agnoli C, Ricceri F, Tumino R, de Magistris MS, Peeters PH, Bueno-de-Mesquita HB, Engeset D, Skeie G, Hjartåker A, Menéndez V, Agudo A, Molina-Montes E, Huerta JM, Barricarte A, Amiano P, Sonestedt E, Nilsson LM, Landberg R, Key TJ, Khaw KT, Wareham NJ, Lu Y, Slimani N, Romieu I, Riboli E, Scalbert A (2016) Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur J Nutr 55:1359–1375. https://doi.org/10.1007/s00394-015-0950-x CrossRefPubMedGoogle Scholar
- 19.Riboli E, Hunt KJ, Slimani N, Ferrari P, Norat T, Fahey M, Charrondière UR, Hémon B, Casagrande C, Vignat J, Overvad K, Tjønneland A, Clavel-Chapelon F, Thiébaut A, Wahrendorf J, Boeing H, Trichopoulos D, Trichopoulou A, Vineis P, Palli D, Bueno-De-Mesquita HB, Peeters PH, Lund E, Engeset D, González CA, Barricarte A, Berglund G, Hallmans G, Day NE, Key TJ, Kaaks R, Saracci R (2002) European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr 5:1113–1124CrossRefGoogle Scholar
- 21.Slimani N, Kaaks R, Ferrari P, Casagrande C, Clavel-Chapelon F, Lotze G, Kroke A, Trichopoulos D, Trichopoulou A, Lauria C, Bellegotti M, Ocké MC, Peeters PH, Engeset D, Lund E, Agudo A, Larrañaga N, Mattisson I, Andren C, Johansson I, Davey G, Welch AA, Overvad K, Tjønneland A, Van Staveren WA, Saracci R, Riboli E (2002) European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study: rationale, design and population characteristics. Public Health Nutr 5:1125–1145CrossRefGoogle Scholar
- 22.Wareham NJ, Jakes RW, Rennie KL, Schuit J, Mitchell J, Hennings S, Day NE (2003) Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr 6:407–413CrossRefGoogle Scholar
- 24.Ferrari P, Kaaks R, Fahey MT, Slimani N, Day NE, Pera G, Boshuizen HC, Roddam A, Boeing H, Nagel G, Thiebaut A, Orfanos P, Krogh V, Braaten T, Riboli E, European Prospective Investigation into Cancer and Nutrition study (2004) Within- and between-cohort variation in measured macronutrient intakes, taking account of measurement errors, in the European Prospective Investigation into Cancer and Nutrition study. Am J Epidemiol 160:814–822CrossRefGoogle Scholar
- 26.Michikawa T, Inoue M, Shimazu T, Sasazuki S, Iwasaki M, Sawada N, Yamaji T, Tsugane S (2011) Green tea and coffee consumption and its association with thyroid cancer risk: a population-based cohort study in Japan. Cancer Causes Control 22:985–993. https://doi.org/10.1007/s10552-011-9771-2 CrossRefPubMedGoogle Scholar
- 28.Edmands WM, Ferrari P, Rothwell JA, Rinaldi S, Slimani N, Barupal DK, Biessy C, Jenab M, Clavel-Chapelon F, Fagherazzi G, Boutron-Ruault MC, Katzke VA, Kühn T, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Grioni S, Tumino R, Vineis P, Mattiello A, Romieu I, Scalbert A (2015) Polyphenol metabolome in human urine and its association with intake of polyphenol-rich foods across European countries. Am J Clin Nutr 102:905–913. https://doi.org/10.3945/ajcn.114.101881 CrossRefPubMedGoogle Scholar