Association between erythrocyte fatty acids in de novo lipogenesis pathway and DXA-derived body fat and trunk fat distribution in Chinese adults: a prospective study
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Higher levels of fatty acids (FAs) in the de novo lipogenesis (DNL) pathway might be associated with higher levels of fat mass (FM), while limited evidence is available from the general population. We aimed to examine the associations between DNL-FAs and body fat and fat distribution in a general population of Chinese adults.
This community-based prospective cohort study included 3,075 participants (68% women) aged 40–75 years in urban Guangzhou, China. We measured erythrocyte DNL-FAs composition (including C16:0, C16:1n-7, C18:0, and C18:1n-9) at baseline and %FM over the total body (TB), trunk, limbs, android (A) and gynoid (G) regions after 3.2 years and 6.3 years of follow-up, respectively.
Generally, higher proportions of individual erythrocyte DNL-FAs and their combined index were positively associated with adipose indices in the multivariable cross-sectional and longitudinal analyses. The cross-sectional percentage mean differences in quartile 4 (vs. 1) of the DNL index were 3.43% (TB), 4.56% (trunk), and 2.67% (A/G ratio) (all P trends < 0.01). The corresponding values in longitudinal changes of adipose indices were 1.40% (TB), 1.78% (trunk), and 1.32% (A) (all P trends < 0.05). The above associations tended to be more pronounced in the trunk and android area than the limbs and gynoid area.
Erythrocyte DNL-FAs may contribute to an increase in total body fat in Chinese adults, particularly FM distributed in trunk and abdominal regions.
KeywordsBody fat Chinese adults De novo lipogenesis Pathway Erythrocyte fatty acids Prospective study
This study was jointly supported by the National Natural Science Foundation of China (Nos. 81472965 and 81602853), Sun Yat-sen University Foundation for Youth Teachers (No. 17ykpy12), the 5010 Program for Clinical Researches (No. 2007032) by the Sun Yat-sen University, Guangzhou, P. R. China. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We are grateful to Mian-li Xiao, Ding Ding, Wen-qi Shi, and Li-ping He, and other team staff for their contribution in the data collection and for facilitating both the recruitment of participants and the interviews.
Compliance with ethical standards
Conflict of interest
None of the authors reported a conflict of interest related to the study.
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