Consumption of soy-based infant formula is not associated with early onset of puberty
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The use of soy products is common in young children with cow milk allergy (CMA). The aim was to examine prospectively the association between infantile consumption of soy-based formula, growth parameters and early pubertal signs, in comparison to cow milk-based formula.
A nested case–control study was conducted, selected from a cohort of infants prospectively followed from birth until the age of 3 years for eating habits and the development of IgE-mediated CMA. Infants who consumed only soy-based formula were included in the soy group. The control group was randomly selected from those without IgE-CMA and not receiving soy formula. Study participants were reevaluated between ages 7.8 and 10.5 years by an interview, nutritional intake by 3 days diaries, and height, weight, and pubertal signs by physical examination.
The soy-fed group included 29 participants (17 males), median age 8.92 years IQR (8.21, 9.42). The control group included 60 participants (27 males), median age 8.99 years IQR (8.35, 9.42). The groups had comparable height and BMI z scores (− 0.17 ± 1.08 versus − 0.16 ± 1.01, p = 0.96, and 0.67 ± 1.01 versus 0.53 ± 1.02, p = 0.56, for soy and control groups, respectively). Four (three males and one female) from the soy-group (13.8%) and eight females from the control-group (13.3%) had early pubertal signs (p = 0.95). No association was detected between puberty and infantile nutrition, after controlling for BMI and family data. No association with puberty or differences between groups were found in current daily consumption of soy, micronutrients, energy, carbohydrates, fat, and protein.
This is the first prospective, physical examination-based study, demonstrating no association between infantile soy-based formula consumption and growth and puberty parameters.
KeywordsGrowth Children BMI Prospective Cow milk allergy Nutritional intake
The authors would like to thank Dr. Aliza Stark for her help in manuscript editing and Dr. Tomer Ziv for the statistical analysis.
Compliance with ethical standards
Conflict of interest
There are no reported conflicts of interest for any of the authors.
Source of funding
Michael R. Goldberg is supported by a Kamea grant from the Ministry of Health, Israel. No honorarium, grant, or other form of payment was given to produce the manuscript.
Website: https://clinicaltrials.gov/ ID Number: NCT02908971.
- 10.Collaborative Group on Hormonal Factors in Breast Cancer (2012) Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet Oncol 13:1141–1151. https://doi.org/10.1016/S1470-2045(12)70425-4 CrossRefGoogle Scholar
- 16.Andres A, Moore MB, Linam LE, Casey PH, Cleves MA, Badger TM (2015) Compared with feeding infants breast milk or cow-milk formula, soy formula feeding does not affect subsequent reproductive organ size at 5 years of age. J Nutr 145:871–875. https://doi.org/10.3945/jn.114.206201 CrossRefGoogle Scholar
- 22.Kuczmarski RJ, Ogden CL, Grummer-Strawn LM et al (2000) CDC growth charts: United States. Adv Data 314:1–27Google Scholar
- 25.Tzameret [computer program] (2010) Version 2. Jerusalem: Israeli Ministry of HealthGoogle Scholar
- 26.National Agricultural Library, United States Department of Agriculture United States: Food and Nutrition Information Center. DRI tables and application reports; Available at: http://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf. Accessed 22 Nov 2017
- 28.Garibaldi L, Chemaitilly W (2015) Disorders of pubertal development. In: Kliegman RM, Stanton BF,, Schor NF, Behrman RE, eds. Nelson textbook of pediatrics St. Geme JW, 20th edn. Elsevier, Philadelphia, pp 2656–2662Google Scholar
- 33.Villamor E, Jansen EC (2016) Nutritional determinants of the timing of puberty. Annu Rev Public Health 37:33–46. https://doi.org/10.1146/annurev-publhealth-031914-122606 CrossRefGoogle Scholar
- 35.Baranowski T (2013) 24-h recall and diet record methods. In: Willett W (ed) Nutritional epidemiology, 3rd edn. Oxford University Press, New York, pp 49–69Google Scholar
- 36.Ministry of Health. Mabat Youth- First Israeli National Health and Nutrition Survey. Available at: https://www.health.gov.il/PublicationsFiles/Mabat_2003-2004-b.pdf. Accessed 22 Nov 2017