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Coffee consumption and risk of physical function impairment, frailty and disability in older adults

  • Marcos D. Machado-Fragua
  • Ellen A. Struijk
  • Auxiliadora Graciani
  • Pilar Guallar-Castillon
  • Fernando Rodríguez-Artalejo
  • Esther Lopez-Garcia
Original Contribution

Abstract

Purpose

Habitual coffee consumption has been associated with lower risk of type 2 diabetes and cardiovascular disease. Since these diseases are main determinants of functional limitations, we have tested the hypothesis that coffee intake is associated with lower risk of physical function impairment, frailty and disability in older adults. We focused on women and those with obesity, hypertension or type 2 diabetes because they are at higher risk of functional limitations.

Methods

Prospective study with 3289 individuals ≥ 60 years from the Seniors-ENRICA cohort. In 2008–2010 coffee consumption was measured through a validated dietary history. Participants were followed up until 2015 to ascertain incident impaired physical function, frailty and disability, assessed by both self-report and objective measures.

Results

Compared with non-drinking coffee, consumption of ≥ 2 cups of coffee/day was associated with lower risk of impaired agility in women (hazard ratio [HR] 0.71, 95% confidence interval [CI] 0.51–0.97, P trend 0.04) and in those with obesity (HR 0.60; 95% CI 0.40–0.90, P trend 0.04). Intake of ≥ 2 cups of coffee/day was also linked to reduced risk of impaired mobility in women (HR 0.66; 95% CI 0.46–0.95, P trend 0.02) and among individuals with hypertension (HR 0.70, 95% CI 0.48–1.00, P trend 0.05). Moreover, among subjects with diabetes, those who consumed ≥ 2 cups/day had lower risk of disability in activities of daily living (HR 0.30, 95% CI 0.11–0.76, P trend 0.01).

Conclusions

In older people, habitual coffee consumption was not associated with increased risk of functional impairment, and it might even be beneficial in women and those with hypertension, obesity or diabetes.

Keywords

Coffee Mobility Agility Frailty Disability 

Abbreviations

IADLs

Instrumental activities of daily living

ADLs

Basic activities of daily living

MEDAS

Mediterranean diet adherence screener

SF-12

12-Item short-form health survey

SPPB

Short Physical Performance Battery

BMI

Body mass index

MMSE

Mini-mental state examination

HR

Hazard ratio

CI

Confidence interval

Notes

Acknowledgements

This work was supported by FIS grants 13/0288, 16/609 and 16/1512 (Instituto de Salud Carlos III, State Secretary of R + D + I, and FEDER/FSE), the FRAILOMIC Initiative (FP7-HEALTH-2012-Proposal No. 305483-2), the ATHLOS project (EU H2020-Project ID: 635316) and the JPI HDHL (SALAMANDER project).

Author contributions

MMF and ELG designed and conducted research; MMF and EAS analyzed data; MMF and ELG wrote the paper; MMF and ELG had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. All authors reviewed the manuscript for important intellectual content and approved the final version.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Study participants gave their informed written consent. The Clinical Research Ethics Committee of ‘La Paz’ University Hospital in Madrid approved the study protocol.

Supplementary material

394_2018_1664_MOESM1_ESM.docx (45 kb)
Supplementary material 1 (DOCX 45 KB)

References

  1. 1.
    Kirkwood TB (2008) A systematic look at an old problem. Nature 451:644–647CrossRefGoogle Scholar
  2. 2.
    Miller EA, Weissert WG (2000) Predicting elderly people’s risk for nursing home placement, hospitalization, functional impairment, and mortality: a synthesis. Med Care Res Rev 57:259–297CrossRefGoogle Scholar
  3. 3.
    Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:M146–M156CrossRefGoogle Scholar
  4. 4.
    Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G (2004) Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 59:M255–M263CrossRefGoogle Scholar
  5. 5.
    Seidel D, Brayne C, Jagger C (2011) Limitations in physical functioning among older people as a predictor of subsequent disability in instrumental activities of daily living. Age Ageing 40:463–469CrossRefGoogle Scholar
  6. 6.
    Collard RM, Boter H, Schoevers RA, Oude Voshaar RC (2012) Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc 60:1487–1492CrossRefGoogle Scholar
  7. 7.
    Seeman TE, Merkin SS, Crimmins EM, Karlamangla AS (2010) Disability trends among older Americans: national health and nutrition examination surveys, 1988–1994 and 1999–2004. Am J Public Health 100:100–107CrossRefGoogle Scholar
  8. 8.
    Börsch-Supan A, Brugiavini A, Jürges H, Mackenbach J, Siegrist J, Weber G (eds) (2005): Health, ageing and retirement in Europe: first results from the survey of health, ageing and retirement in Europe. Mannheim, Research Institute for the Economics of Aging (MEA), University of MannheimGoogle Scholar
  9. 9.
    Cesari M, Pahor M, Bartali B, Cherubini A, Penninx BW, Williams GR, Atkinson H, Martin A, Guralnik JM, Ferrucci L (2004) Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study. Am J Clin Nutr 79:289–294CrossRefGoogle Scholar
  10. 10.
    Ng TP, Aung KCY, Feng L, Scherer SC, Yap KB (2012) Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from the Singapore Longitudinal Ageing Study. Am J Clin Nutr 96:1362–1368CrossRefGoogle Scholar
  11. 11.
    Vercambre MN, Boutron-Ruault MC, Ritchie K, Clavel-Chapelon F, Berr C (2009) Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women. Br J Nutr 102:419–427CrossRefGoogle Scholar
  12. 12.
    Artaud F, Dugravot A, Sabia S, Singh-Manoux A, Tzourio C, Elbaz A (2013) Unhealthy behaviours and disability in older adults: three-city Dijon cohort study. BMJ 347:f4240CrossRefGoogle Scholar
  13. 13.
    Houston DK, Stevens J, Cai J, Haines PS (2005) Dairy, fruit, and vegetable intakes and functional limitations and disability in a biracial cohort: the atherosclerosis risk in communities study. Am J Clin Nutr 81:515–522CrossRefGoogle Scholar
  14. 14.
    Lana A, Rodriguez-Artalejo F, Lopez-Garcia E (2015) Dairy consumption and risk of frailty in older adults: a prospective cohort study. J Am Geriatr Soc 63:1852–1860CrossRefGoogle Scholar
  15. 15.
    León-Muñoz LM, García-Esquinas E, López-García E, Banegas JR, Rodríguez-Artalejo F (2015) Major dietary patterns and risk of frailty in older adults: a prospective cohort study. BMC Med 13:11CrossRefGoogle Scholar
  16. 16.
    Struijk EA, Guallar-Castillon P, Rodriguez-Artalejo F, Lopez-Garcia E (2016) Mediterranean dietary patterns and impaired physical function in older adults. J Gerontol A Biol Sci Med Sci glw208.  https://doi.org/10.1093/gerona/glw208
  17. 17.
    Ding M, Bhupathiraju SN, Chen M, van Dam RM, Hu FB (2014) Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: a systematic review and a dose-response meta-analysis. Diabetes Care 37:569–586CrossRefGoogle Scholar
  18. 18.
    Bhupathiraju SN, Pan A, Manson JE, Willet WC, van Dam RM, Hu FB (2014) Changes in coffee intake and subsequent risk of type 2 diabetes: three large cohorts of US men and women. Diabetologia 57:1346–1354CrossRefGoogle Scholar
  19. 19.
    Ding M, Bhupathiraju SN, Satija A, van Dam RM, Hu FB (2014) Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies. Circulation 129:643–659CrossRefGoogle Scholar
  20. 20.
    Zhang W, Lopez-Garcia E, Li TY, Hu FB, van Dam RM (2009) Coffee consumption and risk of cardiovascular diseases and all-cause Mortality among men with type 2 diabetes. Diabetes Care 32:1043–1045CrossRefGoogle Scholar
  21. 21.
    Stuck AE, Walthert JM, Nikolaus T, Büla CJ, Hohmann C, Beck JC (1999) Risk factors for functional status decline in community-living elderly people: a systematic literature review. Soc Sci Med 48:445–469CrossRefGoogle Scholar
  22. 22.
    Yokota RC, Van der Heyden J, Nusselder WJ, Robine JM, Tafforeau J, Deboosere P, Van Oyen H (2016) Impact of chronic conditions and multimorbidity on the disability burden in the older population in Belgium. J Gerontol A Biol Sci Med Sci 71:903–909CrossRefGoogle Scholar
  23. 23.
    Wheaton FV, Crimmins EM (2016) Female disability disadvantage: a global perspective on sex differences in physical function and disability. Ageing Soc 36:1136–1156CrossRefGoogle Scholar
  24. 24.
    Liaw FY, Kao TW, Wu LW, Wang CC, Yang HF, Peng TC, Sun YS, Chang YW, Chen WL (2016) Components of metabolic syndrome and the risk of disability among the elderly population. Sci Rep 6:22750CrossRefGoogle Scholar
  25. 25.
    Wong E, Stevenson C, Backholer K, Woodward M, Shaw JE, Peeters A (2015) Predicting the risk of physical disability in old age using modifiable mild-life risk factors. J Epidemiol Community Health 69:70–76CrossRefGoogle Scholar
  26. 26.
    Balzi D, Lauretani F, Barchielli A, Ferrucci L, Bandinelli S, Buiatti E, Milaneschi Y, Guralnik JM (2010) Risk factors for disability in older persons over 3-year follow-up. Age Ageing 39:92–98CrossRefGoogle Scholar
  27. 27.
    Rodriguez-Artalejo F, Graciani A, Guallar-Castillón P, León-Muñoz LM, Zuluaga MC, López-García E, Gutiérrez-Fisac JL, Taboada JM, Aguilera MT, Regidor E et al (2011) Rationale and methods of the study on nutrition and cardiovascular risk in Spain (ENRICA). Rev Esp Cardiol 64:876–882CrossRefGoogle Scholar
  28. 28.
    Guallar-Castillón P, Sagardui-Villamor J, Balboa-Castillo T, Sala-Vila A, Ariza Astolfi MJ, Sarrión Pelous MD, León-Muñoz LM, Graciani A, Laclaustra M, Benito C et al (2014) Validity and reproducibility of a Spanish dietary history. PLoS ONE 9:e86074CrossRefGoogle Scholar
  29. 29.
    Willet WC (2012) Nutritional epidemiology. Third Edition. Oxford University Press, New YorkCrossRefGoogle Scholar
  30. 30.
    Schöder H, Fitó M, Estruch R, Martínez-González MA, Corella D, Salas-Salvadó J, Lamuela-Raventós R, Ros E, Salaverría I, Fiol M et al (2011) A short screener is valid for assessing Mediterranean diet adherence among older Spanish men and women. J Nutr 141:1140–1145CrossRefGoogle Scholar
  31. 31.
    Rosow I, Breslau N (1966) A Guttman health scale for the aged. J Gerontol 21:556–559CrossRefGoogle Scholar
  32. 32.
    Vilagut G, Valderas JM, Ferrer M, Garin O, López-García E, Alonso J (2008) Interpretation of SF-36 and SF-12 questionnaires in Spain: physical and mental components. Med Clin 130:726–735CrossRefGoogle Scholar
  33. 33.
    Bjorner JB, Wallenstein GV, Martin MC, Lin P, Blaisdell-Gross B, Tak Piech C, Mody SH (2007) Interpreting score differences in the SF-36 Vitality scale: using clinical conditions and functional outcomes to define the minimally important difference. Curr Med Res Opin 23:731–739CrossRefGoogle Scholar
  34. 34.
    Guralnik JM, Ferrucci L, Pieper CF, Leveille SG, Markides KS, Ostir GV, Studenski S, Berkman LF, Wallace RB (2000) Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Sci Med Sci 55:M221–M231CrossRefGoogle Scholar
  35. 35.
    Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9:179–186CrossRefGoogle Scholar
  36. 36.
    García-Esquinas E, Pérez-Hernández B, Guallar-Castillón P, Banegas JR, Ayuso-Mateos JL, Rodríguez-Artalejo F (2016) Housing conditions and limitations in physical function among older adults. J Epidemiol Community Health 70(10):954–960CrossRefGoogle Scholar
  37. 37.
    Katz S (1983) Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. J Am Geriatr Soc 31:721–727CrossRefGoogle Scholar
  38. 38.
    Martínez-Gómez D, Guallar-Castillón P, León-Muñoz LM, López-García E, Rodríguez-Artalejo F (2013) Combined impact of traditional and non-traditional health behaviors on mortality: a national prospective cohort study in Spanish older adults. BMC Med 11:47CrossRefGoogle Scholar
  39. 39.
    Pols MA, Peeters PH, Ocke MC, Slimani N, Bueno-de-Mesquita HB, Collette HJ (1997) Estimation of reproducibility and relative validity of the questions included in the EPIC physical activity questionnaire. Int J Epidemiol 26:S181-9CrossRefGoogle Scholar
  40. 40.
    Graciani A, Banegas JR, Guallar-Castillón P, Domínguez-Rojas V, Rodríguez-Artalejo F (2006) Cognitive assessment of the non-demented elderly community dwellers in Spain. Dement Geriatr Cogn Disord 21:104–112CrossRefGoogle Scholar
  41. 41.
    Morley JE, Malmstrom TK, Miller DK (2012) A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging 16:601–608CrossRefGoogle Scholar
  42. 42.
    Vestergaard S, Nayfield SG, Patel KV, Eldadah B, Cesari M, Ferrucci L, Ceresini G, Guralnik JM (2009) Fatigue in a representative population of older persons and its association with functional impairment, functional limitation and disability. J Gerontol A Biol Sci Med Sci 64:76–82CrossRefGoogle Scholar
  43. 43.
    Bickenbach JE, Chatterji S, Badley EM, Üstün TB (1999) Models of disablement, universalism and the international classification of impairments, disabilities and hadicaps. Soc Sci Med 48:1173–1187CrossRefGoogle Scholar
  44. 44.
    Simeonsson RJ, Lollar D, Hollowell J, Adams M (2000) Revision of the international classification of impairments, disabilities, and handicaps: developmental issues. J Clin Epidemiol 53:113–124CrossRefGoogle Scholar
  45. 45.
    Verbrugge LM, Jette AM (1994) The disablement process. Soc Sci Med 38:1–14CrossRefGoogle Scholar
  46. 46.
    Cesari M, Nobili A, Vitale G (2016) Frailty and sarcopenia: from theory to clinical implementation and public health relevance. Eur J Intern Med 35:1–9CrossRefGoogle Scholar
  47. 47.
    Dirks-Naylor AJ (2015) The benefits of coffee on skeletal muscle. Life Sci 143:182–186CrossRefGoogle Scholar
  48. 48.
    Guo Y, Niu K, Okazaki T, Wu H, Yoshikawa T, Ohrui T, Furukawa K, Ichinose M, Yanai K, Arai H et al (2014) Coffee treatment prevents the progression of sarcopenia in aged mice in vivo and in vitro. Exp Gerontol 50:1–8CrossRefGoogle Scholar
  49. 49.
    Pietrocola F, Malik SA, Mariño G, Vacchelli E, Senovilla L, Chaba K, Niso-Santano M, Maiuri MC, Madeo F, Kroemer G (2014) Coffee induces autophagy in vivo. Cell Cycle 13:1987–1994CrossRefGoogle Scholar
  50. 50.
    de Rekeneire N, Volpato S (2015) Physical function and disability in older adults with diabetes. Clin Geriatr Med 31:51–65CrossRefGoogle Scholar
  51. 51.
    Leenders M, Verdijk LB, van der Hoeven L, Adam JJ, van Kranenburg J, Nilwik R, van Loon LJ (2013) Patients with type 2 diabetes show a greater decline in muscle mass, muscle strength, and functional capacity with aging. J Am Med Dir Assoc 14:585–592CrossRefGoogle Scholar
  52. 52.
    Gross G, Jaccaud E, Huggett AC (1997) Analysis of the content of the diterpenes cafestol and kahweol in coffee brews. Food Chem Toxicol 35:547–554CrossRefGoogle Scholar
  53. 53.
    Ludwig IA, Clifford MN, Lean ME, Ashihara H, Crozier A (2014) Coffee: biochemistry and potential impact on health. Food Funct 5:1695–1717CrossRefGoogle Scholar
  54. 54.
    Jee SH, He J, Appel LJ, Whelton PK, Suh I, Klag MJ (2001) Coffee consumption and serum lipids: a meta analysis of randomized controlled clinical trials. Am J Epidemiol 153:353–362CrossRefGoogle Scholar
  55. 55.
    Bak AA, Grobbee DE (1989) The effect on serum cholesterol levels of coffee brewed by filtering or boiling. N Engl J Med 321:1432–1437CrossRefGoogle Scholar
  56. 56.
    Urgert R, Katan MB (1996) The cholesterol-raising factor from coffee beans. J R Soc Med 89:618–623CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Preventive Medicine and Public Health, School of MedicineUniversidad Autónoma de MadridMadridSpain
  2. 2.IdiPaz (Instituto de Investigación Sanitaria Hospital Universitario La Paz)MadridSpain
  3. 3.CIBERESP (CIBER of Epidemiology and Public Health)MadridSpain
  4. 4.IMDEA-Food Institute, CEI UAM+CSICMadridSpain

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