European Journal of Nutrition

, Volume 57, Issue 2, pp 833–843 | Cite as

Effects of supplementation with rice husk powder and rice bran on inflammatory factors in overweight and obese adults following an energy-restricted diet: a randomized controlled trial

  • Fahimeh Edrisi
  • Mousa SalehiEmail author
  • Afsane Ahmadi
  • Mohamad Fararoei
  • Fatemeh Rusta
  • Salma Mahmoodianfard
Original Contribution



Overweight and obesity are major public health concerns worldwide which are associated with a low-grade chronic inflammation. Dietary fiber as an important component of diet could be effective in controlling weight and inflammatory factors. The present study aimed to compare the effects of rice husk powder and rice bran on inflammatory factors along with an energy-restricted diet in overweight and obese adults.


In this randomized trial, 105 eligible individuals were assigned to one of the three energy-restricted diet groups receiving; rice bran (n = 35), rice husk powder (n = 35), and control group (n = 35) for 12 weeks. Demographic data, dietary intake, anthropometric indices and inflammatory factors (serum levels of IL-6 and hs-CRP) were measured at baseline and at the end of the study.


Weight, BMI and waist circumference reduced significantly in all groups after 12 weeks of study (P < 0.01 for all). However, pre- and post-measure differences between groups were not significant. Moreover, serum levels of hs-CRP and IL-6 were not significantly different between participants in the rice bran or rice husk groups. However, the reduction in serum levels of hs-CRP in rice husk (mean change = − 0.14 ± 0.05 µg/ml) and rice bran (mean change = − 0.13 ± 0.03 µg/ml) was significantly higher when compared to the control group (mean change = − 0.03 ± 0.02 µg/ml) (P < 0.05 for both groups). The same pattern was found when changes in IL-6 serum levels of participants in rice husk (mean change = − 0.48 ± 0.11 pg/ml) and rice bran (mean change = − 0.57 ± 0.13 pg/ml) groups were compared to the control group (mean change= − 0.19 ± 0.07 pg/ml) (P < 0.05 for both groups).


The results of this study showed positive effects of rice bran and rice husk powder supplementation, combined with an energy-restricted diet, on inflammatory markers among overweight and obese adults.


Rice bran Rice husk Overweight Obesity IL-6 Hs-CRP 



The present paper is part of a master’s thesis in Nutritional Sciences in 2014–2015. We thank Ms. Ghahramani for their cooperation in conducting the study and Shiraz Trauma Center employee who participated in this study.

Author contributions

All authors were involved in the concept and design of the study. The authors’ responsibilities were as follows: MS supervised the study and edited the final manuscript. FE contributed to conducting the study, collected the data and wrote the article. AA contributed to conducting the study and provided advice. MF analyzed and interpreted the data, FR contributed to collecting the data and SM contributed to collecting the data and wrote the article. On behalf of all authors, the corresponding author states that there is no conflict of interest. All the authors have approved the final article.

Compliance with ethical standards


This study was supported financially by the Vice-Chancellor of Research, Shiraz University of Medical Sciences, and implemented in collaboration with Shiraz Trauma Center, Shiraz University of Medical Sciences, Shiraz, Iran.


  1. 1.
    World Health Organization (2016) Obesity and overweight. Fact sheet N 311. Accessed 19 June 2017
  2. 2.
    Anty R, Bekri S, Luciani N, Saint-Paul M-C, Dahman M, Iannelli A et al (2006) The inflammatory C-reactive protein is increased in both liver and adipose tissue in severely obese patients independently from metabolic syndrome, Type 2 diabetes, and NASH. Am J Gastroenterol 101(8):1824–1833CrossRefGoogle Scholar
  3. 3.
    Ridker PM (2007) C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: moving an inflammatory hypothesis toward consensus. J Am Coll Cardiol 49(21):2129–2138CrossRefGoogle Scholar
  4. 4.
    Nestle M, Jacobson MF (2000) Halting the obesity epidemic: a public health policy approach. Public Health Rep 115(1):12–24CrossRefGoogle Scholar
  5. 5.
    Abdollahi M, Afshar-Imani B (2003) A review on obesity and weight loss measures. Middle East Pharm 11(5):6–10Google Scholar
  6. 6.
    Abete I, Goyenechea E, Zulet M, Martinez J (2011) Obesity and metabolic syndrome: potential benefit from specific nutritional components. Nutr Metab Cardiovasc Dis 21:B1-B15CrossRefGoogle Scholar
  7. 7.
    Keys A, Anderson JT, Grande F (1960) Diet-type (fats constant) and blood lipids in man. J Nutr 70:257–266CrossRefGoogle Scholar
  8. 8.
    Cho SS, Qi L, Fahey GC, Klurfeld DM (2013) Consumption of cereal fiber, mixtures of whole grains and bran, and whole grains and risk reduction in type 2 diabetes, obesity, and cardiovascular disease. Am J Clin Nutr. doi: 10.3945/ajcn.113.067629 Google Scholar
  9. 9.
    Johansson-Persson A, Ulmius M, Cloetens L, Karhu T, Herzig K-H, Önning G (2014) A high intake of dietary fiber influences C-reactive protein and fibrinogen, but not glucose and lipid metabolism, in mildly hypercholesterolemic subjects. Eur J Nutr 53(1):39–48CrossRefGoogle Scholar
  10. 10.
    Huang T, Xu M, Lee A, Cho S, Qi L (2015) Consumption of whole grains and cereal fiber and total and cause-specific mortality: prospective analysis of 367,442 individuals. BMC Med 13(1):59CrossRefGoogle Scholar
  11. 11.
    Alexandratos N, Bruinsma J (2012) World agriculture towards 2030/2050: the 2012 revision. ESA Working paper, RomeGoogle Scholar
  12. 12.
    Henderson AJ, Ollila CA, Kumar A, Borresen EC, Raina K, Agarwal R et al (2012) Chemopreventive properties of dietary rice bran: Current status and future prospects. Adv Nutr 3(5):643–653CrossRefGoogle Scholar
  13. 13.
    Camire M, Cho S, Craig S, Devrie J, Gordon D, Jones J et al (2001) The definition of dietary fiber. Cereal Foods World 46(3):112–124Google Scholar
  14. 14.
    Butsat S, Siriamornpun S (2010) Antioxidant capacities and phenolic compounds of the husk, bran and endosperm of Thai rice. Food Chem 119(2):606–613CrossRefGoogle Scholar
  15. 15.
    Wilson TA, Nicolosi RJ, Woolfrey B, Kritchevsky D (2007) Rice bran oil and oryzanol reduce plasma lipid and lipoprotein cholesterol concentrations and aortic cholesterol ester accumulation to a greater extent than ferulic acid in hypercholesterolemic hamsters. J Nutr Biochem 18(2):105–112CrossRefGoogle Scholar
  16. 16.
    Phutthaphadoong S, Yamada Y, Hirata A, Tomita H, Hara A, Limtrakul P et al (2010). Chemopreventive effect of fermented brown rice and rice bran (FBRA) on the inflammation-related colorectal carcinogenesis in ApcMin/+ mice. Oncol Rep 23(1):53–59Google Scholar
  17. 17.
    Gingras L, Mathewson P, Patel RM (2008) Rice hull composition. United States patent application US 12/317,085. 19 Dec 2008Google Scholar
  18. 18.
    Zavoshy R, Noroozi M, Jahanihashemi H (2012) Effect of low calorie diet with rice bran oil on cardiovascular risk factors in hyperlipidemic patients. J Res Med Sci 17(7):626–631Google Scholar
  19. 19.
    Nagendra Prasad MNSK, Shravya Khatokar M, Vismaya MN, Nanjunda Swamy S (2011) Health benefits of rice bran—a review. J Nutr Food Sci 1(3):1–7. doi: 10.4172/2155-9600.1000108JNFS CrossRefGoogle Scholar
  20. 20.
    Brown L, Rosner B, Willett WW, Sacks FM (1999) Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 69(1):30–42CrossRefGoogle Scholar
  21. 21.
    St-Onge M-P, Gallagher D (2010) Body composition changes with aging: the cause or the result of alterations in metabolic rate and macronutrient oxidation? Nutrition 26(2):152–155CrossRefGoogle Scholar
  22. 22.
    Ning H, Van Horn L, Shay CM, Lloyd-Jones DM (2014) Associations of dietary fiber intake with long-term predicted cardiovascular disease risk and C-reactive protein levels (from the National Health and Nutrition Examination Survey Data [2005–2010]). Am J Cardiol 113(2):287–291CrossRefGoogle Scholar
  23. 23.
    Trumbo P, Schlicker S, Yates AA, Poos M (2002) Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. J Am Diet Assoc 102(11):1621–1630CrossRefGoogle Scholar
  24. 24.
    World Health Organization (2003) Diet, nutrition and the prevention of chronic diseases. WHO technical report series 916. Accessed 24 Sept 2017
  25. 25.
    Pal S, Khossousi A, Binns C, Dhaliwal S, Ellis V (2011) The effect of a fibre supplement compared to a healthy diet on body composition, lipids, glucose, insulin and other metabolic syndrome risk factors in overweight and obese individuals. Br J Nutr 105(01):90–100CrossRefGoogle Scholar
  26. 26.
    Ireton-Jones AS (2012) Intake: energy. In: Mahan L, Escott Stump S, Raymond (eds) Krause’s food & the nutrition care process (Krause’s Food & Nutrition Therapy), 13rd edn. WB Saunders. Elsevier, Philadelphia, pp 25–26Google Scholar
  27. 27.
    Kathleen AH. Mary DL (2012) clinical: Inflammation, physical and functional assessment. In: Mahan L, Escott Stump S, Raymond J (eds) Krause’s food & the nutrition care process (Krause’s Food & Nutrition Therapy), 13rd edn. WB Saunders. Elsevier, Philadelphia, pp 165–169Google Scholar
  28. 28.
    Booth ML, Ainsworth BE, Pratt MI, Ekelund U, Yngve AG, Sallis JF et al (2003) International physical activity questionnaire: 12-country reliability and validity. Med sci sports Exerc 195(9131/03): 3508–1381Google Scholar
  29. 29.
    Feinman RD (2009) Intention-to-treat. What is the question? Nutr Metab (Lond). doi: 10.1186/1743-7075-6-1 Google Scholar
  30. 30.
    Kazemzadeh M, Safavi SM, Nematollahi S, Nourieh Z (2014) Effect of brown rice consumption on inflammatory marker and cardiovascular risk factors among overweight and obese non-menopausal female adults. Int J Prev Med 5(4):478–488Google Scholar
  31. 31.
    Hermsdorff HHM, Zulet MÁ, Abete I, Martínez JA (2011) A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects. Eur J Nutr 50(1):61–69CrossRefGoogle Scholar
  32. 32.
    Papathanasopoulos A, Camilleri M (2010) Dietary fiber supplements: effects in obesity and metabolic syndrome and relationship to gastrointestinal functions. Gastroenterology 138(1):65–72CrossRefGoogle Scholar
  33. 33.
    King DE (2005) Dietary fiber, inflammation, and cardiovascular disease. Mol Nutr Food Res 49(6):594–600CrossRefGoogle Scholar
  34. 34.
    Galisteo M, Duarte J, Zarzuelo A (2008) Effects of dietary fibers on disturbances clustered in the metabolic syndrome. J Nutr Biochem 19(2):71–84CrossRefGoogle Scholar
  35. 35.
    Ma Y, Griffith JA, Chasan-Taber L, Olendzki BC, Jackson E, Stanek EJ et al (2006) Association between dietary fiber and serum C-reactive protein. Am J Clin Nutr 83(4):760–766CrossRefGoogle Scholar
  36. 36.
    Wang O, Liu J, Cheng Q, Guo X, Wang Y, Zhao L et al (2015) Effects of ferulic acid and γ-oryzanol on high-fat and high-fructose diet-induced metabolic syndrome in rats. PloS one 10(2):e0118135CrossRefGoogle Scholar
  37. 37.
    Selvin E, Paynter NP, Erlinger TP (2007) The effect of weight loss on C-reactive protein: a systematic review. Arch Intern Med 167(1):31–39CrossRefGoogle Scholar
  38. 38.
    Borges RL, Ribeiro-Filho FF, Carvalho KMB, Zanella MT (2007) Impact of weight loss on adipocytokines, C-reactive protein and insulin sensitivity in hypertensive women with central obesity. Arq Bras Cardiol 89(6):409–414CrossRefGoogle Scholar
  39. 39.
    Faam B ZM, Daneshpour M, Azizi F, Hedayati M (2014) association between abdominal obesity and hs-CRP, IL-6 and HCY in tehranian adults: TLGS. J Diabetes Metab Disord 13(2):163–171Google Scholar
  40. 40.
    Sindhu S, Thomas R, Shihab P, Sriraman D, Behbehani K, Ahmad R (2015) Obesity is a positive modulator of IL-6R and IL-6 expression in the subcutaneous adipose tissue: significance for metabolic inflammation. PLoS One 10(7):e0133494. doi: 10.1371/journal.pone.0133494 CrossRefGoogle Scholar
  41. 41.
    Ma Y, Hébert JR, Li W, Bertone-Johnson ER, Olendzki B, Pagoto SL et al (2008) Association between dietary fiber and markers of systemic inflammation in the Women’s Health Initiative Observational Study. Nutrition 24(10):941–949CrossRefGoogle Scholar
  42. 42.
    Grooms KN, Ommerborn MJ, Pham DQ, Djoussé L, Clark CR (2013) Dietary fiber intake and cardiometabolic risks among US adults, NHANES 1999–2010. Am J Med 126(12):1059–1067CrossRefGoogle Scholar
  43. 43.
    North C, Venter C, Jerling J (2009) The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease. Eur J Clin Nutr 63(8):921–933CrossRefGoogle Scholar
  44. 44.
    Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M et al (2002) Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans role of oxidative stress. Circulation 106(16):2067–2072CrossRefGoogle Scholar
  45. 45.
    Krogh-Madsen R, Plomgaard P, Keller P, Keller C, Pedersen BK (2004) Insulin stimulates interleukin-6 and tumor necrosis factor-α gene expression in human subcutaneous adipose tissue. Am J Physiol Endocrinol Metab 286(2):E234–E238CrossRefGoogle Scholar
  46. 46.
    Vicennati V, Vottero A, Friedman C, Papanicolaou D (2002) Hormonal regulation of interleukin-6 production in human adipocytes. Int J Obes Relat Metab Disord 26(7):905–911CrossRefGoogle Scholar
  47. 47.
    Florez H, Castillo-Florez S, Mendez A, Casanova-Romero P, Larreal-Urdaneta C, Lee D et al (2006) C-reactive protein is elevated in obese patients with the metabolic syndrome. Diabetes Res Clin Pract 71(1):92–100CrossRefGoogle Scholar
  48. 48.
    Theuwissen E, Plat J, Mensink RP (2009) Consumption of oat β-glucan with or without plant stanols did not influence inflammatory markers in hypercholesterolemic subjects. Mol Nutr Food Res 53(3):370–376CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Fahimeh Edrisi
    • 1
  • Mousa Salehi
    • 1
    Email author
  • Afsane Ahmadi
    • 1
  • Mohamad Fararoei
    • 2
  • Fatemeh Rusta
    • 3
  • Salma Mahmoodianfard
    • 3
  1. 1.Department of Clinical Nutrition, School of Nutrition and Food SciencesShiraz University of Medical SciencesShirazIran
  2. 2.HIV/AIDs Research CenterShiraz University of Medical SciencesShirazIran
  3. 3.Department of Clinical Nutrition, Shiraz Trauma CenterShiraz University of Medical SciencesShirazIran

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