A modified response of NAFLD patients with non-significant fibrosis in nutritional counseling according to GCKR rs1260326
- 226 Downloads
To investigate the association between GCKR gene and nutritional treatment in NAFLD-related biomarkers.
This was an open-label and single-arm clinical trial in 44 overweight or obese adults with NAFLD receiving nutritional counseling for 6 months. Nutritional data, MedDietScore, clinical, biochemical, inflammatory and oxidative stress biomarkers were evaluated before and after intervention. Further, we genotyped GCKR rs1260326 and in T-allele carriers and non-Τ-carriers we assessed associations between the GCKR variant and nutritional counseling related to change in all biomarkers evaluated.
Anthropometric measurements were significantly reduced after the end of the intervention in patients assigned to nutritional counseling. Liver imaging and fibrosis were significantly improved. GCKR rs1260326 T-allele frequency was 46.7%. T-carriers responded better to nutritional counseling regarding fasting blood glucose levels (mean6-0 change = −4.94 mg/dL (±9.33), p = 0.005), whereas non-T-carriers did not benefit from the intervention regarding glucose. On the other hand, levels of oxLDL decreased in the non-T-carriers group after the intervention, but not in T-carriers.
Our results show that GCKR rs1260326 T-allele is associated with better response of NAFLD patients to nutritional treatment regarding fasting blood glucose, but not oxLDL levels. Despite this important finding in the field of nutrigenetics, it is tricky to generalize this effect unless larger studies are conducted.
KeywordsNAFLD Nutrition Genetics GCKR Response Counseling Fasting glucose oxLDL
I.P. Kalafati and G.V. Dedoussis were funded by “Research Project For Excellence ΙΚΥ/SIEMENS”. This study was partially funded by the “Obesity and metabolic syndrome: dietary intervention with Greek raisins in NAFLD/NASH Investigation of molecular mechanisms” reviewed and approved by the Greek Secretariat for Research and Technology (Cooperation 890/2009). Additionally, this study was reviewed by Harokopio University and “Laiko” General Hospital Athens University Medical School Institutional Review Boards.
Compliance with ethical standards
Conflict of interest
No potential conflicts of interest relevant to this article were reported.
- 15.Vaxillaire M, Cavalcanti-Proença C, Dechaume A, Tichet J et al (2008) The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective General French Population. Diabetes 57:2253–2257CrossRefPubMedPubMedCentralGoogle Scholar
- 27.Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report (2002). Circulation 106:3143Google Scholar