Regularly consuming a green/roasted coffee blend reduces the risk of metabolic syndrome
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Preventive health effects of coffee could have a widespread impact on public health. Green coffee has more phenols than roasted, and thus is healthier, although with less acceptable organoleptic properties. Therefore, the effects of regularly consuming a green/roasted coffee blend (35/65) on the main components of MetS in humans were evaluated.
A crossover, randomized, controlled study was performed in 25 normocholesterolaemic and 27 hypercholesterolaemic men and women aged 18–45 years with BMI 18–25 kg/m2. Three servings/day of the blend, providing 510.6 mg hydroxycinnamic acids and 121.2 mg caffeine/day, were consumed versus a control drink, during 8 weeks each. Polyphenol and methylxanthine-rich foods were restricted along the study. At the beginning (baseline) and end of the control and coffee interventions, blood samples were collected and glucose, HDL-cholesterol, triglycerides, insulin, leptin, plasminogen activator inhibitor-1 (PAI-1), resistin and visfatin were analysed; waist circumference, %body fat, and blood pressure were measured and dietary records and physical activity questionnaires completed.
Systolic and diastolic blood pressure decreased (p = 0.001 and p < 0.001, respectively) in both groups as well as %body fat (p = 0.001) which may be related to the lower leptin (p = 0.001), PAI-1 (p < 0.001) and resistin (p = 0.034) levels in the two groups after coffee consumption. Glucose concentration (p = 0.030) and insulin resistance (p = 0.011; HOMA-IR) also decreased, as well as triglyceride levels (p = 0.017), so that the reduction was much greater in the hypercholesterolaemics (group effect, p = 0.027).
Regular consumption of the green/roasted coffee blend may be recommended to healthy and hypercholesterolaemic subjects to prevent MetS, as it produces positive effects on blood pressure, glucose and triglyceride levels.
KeywordsCoffee Hydroxycinnamic acids Diabetes Hypertension Weight loss Metabolic syndrome
Body mass index
High-density lipoprotein cholesterol
Homoeostasis model assessment-insulin resistance index
Plasminogen activator inhibitor-1
Project AGL2010-18269 from the Spanish Ministry of Economy and Competitivity is acknowledged. We want to thank the volunteers who participated in the study and M. Jimenez and L. T. Cayuelas for their assistance in dietary records analysis. S.M.-L. thanks the Spanish National Research Council for her pre-doctoral fellowship under the JAE-Pre programme funded by the European Social Fund.
Compliance with ethical standards
Conflict of interest
The authors declare that there is no conflict of interest.
- 8.Meng S, Cao J, Feng Q, Peng J, Hu Y (2013) Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review. Evid Based Complement Altern Med 801457Google Scholar
- 12.Hino A, Adachi H, Enomoto M, Furuki K, Shigetoh Y, Ohtsuka M, Kumagae S, Hirai Y, Jalaldin A, Satoh A, Imaizumi T (2007) Habitual coffee but not green tea consumption is inversely associated with metabolic syndrome: an epidemiological study in a general Japanese population. Diabetes Res Clin Pract 76:383–389CrossRefGoogle Scholar
- 14.Takami H, Nakamoto M, Uemura H, Katsuura S, Yamaguchi M, Hiyoshi M, Sawachika F, Juta T, Arisawa K (2013) Inverse correlation between coffee consumption and prevalence of metabolic syndrome: baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima, Japan. J Epidemiol 23:12–20CrossRefGoogle Scholar
- 17.Kastorini CM, Panagiotakos DB (2010) The role of the mediterranean diet on the development of the metabolic syndrome. Front Biosci (Elite Ed) 2:1320–1333Google Scholar
- 21.Moreiras O, Carbajal A, Cabrera L, Cuadrado C (2009) In Tablas de composición de alimentos, ed. Pirámide. 13th edn. Ediciones Pirámide, Madrid, SpainGoogle Scholar
- 24.Mateos R, Gómez-Juaristi M, Martínez-López S, Baeza G, Amigo-Benavent M, Sarriá B, Bravo-Clemente L (2015) Bioavailability of hydroxycinnamate derivatives after consuming a soluble green/roasted coffee blend by healthy humans. Poster presented in the International Congress: EuroFoodChem XVIII, MadridGoogle Scholar
- 32.Tsioufis C, Dimitriadis K, Vasiliadou C, Taxiarchou E, Vezali E, Tsiamis E, Stefanadis C, Kallikazaros I (2006) Heavy coffee consumption in conjunction with smoking is accompanied by increased inflammatory processes and impaired thrombosis/fibrinolysis system in essential hypertensive subjects. J Hum Hypertens 20:470–472CrossRefGoogle Scholar
- 38.Saito I, Tsuchida T, Watanabe T, Arai Y, Mitsui Y, Okawa W, Kajihara Y (2002) Effect of coffee bean extract in essential hypertension. Jpn J Med Pharm Sci 47:67–74Google Scholar