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European Journal of Nutrition

, Volume 56, Issue 4, pp 1509–1521 | Cite as

A meta-analysis of efficacy of Morus alba Linn. to improve blood glucose and lipid profile

  • Wiraphol PhimarnEmail author
  • Kittisak Wichaiyo
  • Khuntawan Silpsavikul
  • Bunleu Sungthong
  • Kritsanee Saramunee
Original Contribution

Abstract

Purpose

The previous studies have reported the Morus alba may improve blood glucose and lipid profile. The evidence from these studies is not consistent. This meta-analysis was to evaluate efficacy of products derived from M. alba on blood glucose and lipid levels.

Methods

Literature was reviewed via international database (PubMed, PubMed Central, ScienceDirect, and SciSearch) and Thai databases. Thirteen RCTs with high quality, assessed by Jadad score, were included.

Results

M. alba expressed a significant reduction in postprandial glucose (PPG) at 30 min (MD −1.04, 95 % CI −1.36, −0.73), 60 min (MD −0.87, 95 % CI −1.27, −0.48) and 90 min (MD −0.55, 95 % CI −0.87, −0.22). The difference was not found in the levels of other glycaemic (FBS, HbA1C, or HOMA-IR) and lipidaemic (TC, TG, LDL, or HDL) markers. Serious adverse effects were found neither in the control nor in the group received M. alba.

Conclusion

Products derived from M. alba can effectively contribute to the reduction in PPG levels, but large-scale RCTs would be informative.

Keywords

Mulberry (Morus albaDiabetes mellitus Dyslipidaemia Blood glucose Blood lipid 

Abbreviations

MD

Mean difference

CI

Confidence interval

PPG

Postprandial glucose

FBS

Fasting blood sugar

HbA1C

Hemoglobin A1C

HOMA-IR

Homeostatic model assessment insulin resistance

TC

Total cholesterol

TG

Triglyceride

LDL

Low density lipoprotein cholesterol

HDL

High-density lipoprotein cholesterol

PRISMA

Preferred reporting items for systematic reviews and meta-analyses

SE

Standard error

RCT

Randomized control trial

Notes

Acknowledgments

The authors wish to thank Dr. Pamela Voulalas, School of Pharmacy, University of Maryland for language editorial assistance.

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Supplementary material

394_2016_1197_MOESM1_ESM.docx (270 kb)
Supplementary material 1 (DOCX 269 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Wiraphol Phimarn
    • 1
    Email author
  • Kittisak Wichaiyo
    • 1
  • Khuntawan Silpsavikul
    • 1
  • Bunleu Sungthong
    • 2
  • Kritsanee Saramunee
    • 1
  1. 1.Social Pharmacy Research Unit, Faculty of PharmacyMahasarakham UniversityKantharawichaiThailand
  2. 2.Pharmaceutical Chemistry and Natural Products Research Unit, Faculty of PharmacyMahasarakham UniversityKantharawichaiThailand

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