A meta-analysis of efficacy of Morus alba Linn. to improve blood glucose and lipid profile
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The previous studies have reported the Morus alba may improve blood glucose and lipid profile. The evidence from these studies is not consistent. This meta-analysis was to evaluate efficacy of products derived from M. alba on blood glucose and lipid levels.
Literature was reviewed via international database (PubMed, PubMed Central, ScienceDirect, and SciSearch) and Thai databases. Thirteen RCTs with high quality, assessed by Jadad score, were included.
M. alba expressed a significant reduction in postprandial glucose (PPG) at 30 min (MD −1.04, 95 % CI −1.36, −0.73), 60 min (MD −0.87, 95 % CI −1.27, −0.48) and 90 min (MD −0.55, 95 % CI −0.87, −0.22). The difference was not found in the levels of other glycaemic (FBS, HbA1C, or HOMA-IR) and lipidaemic (TC, TG, LDL, or HDL) markers. Serious adverse effects were found neither in the control nor in the group received M. alba.
Products derived from M. alba can effectively contribute to the reduction in PPG levels, but large-scale RCTs would be informative.
KeywordsMulberry (Morus alba) Diabetes mellitus Dyslipidaemia Blood glucose Blood lipid
Fasting blood sugar
Homeostatic model assessment insulin resistance
Low density lipoprotein cholesterol
High-density lipoprotein cholesterol
Preferred reporting items for systematic reviews and meta-analyses
Randomized control trial
The authors wish to thank Dr. Pamela Voulalas, School of Pharmacy, University of Maryland for language editorial assistance.
Compliance with ethical standards
Conflict of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest.
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