European Journal of Nutrition

, Volume 56, Issue 3, pp 1347–1357 | Cite as

Acute intake of quercetin from onion skin extract does not influence postprandial blood pressure and endothelial function in overweight-to-obese adults with hypertension: a randomized, double-blind, placebo-controlled, crossover trial

  • Verena Brüll
  • Constanze Burak
  • Birgit Stoffel-Wagner
  • Siegfried Wolffram
  • Georg Nickenig
  • Cornelius Müller
  • Peter Langguth
  • Birgit Alteheld
  • Rolf Fimmers
  • Peter Stehle
  • Sarah Egert
Original Contribution

Abstract

Purpose

To determine whether postprandial metabolic and vascular responses induced by a high-fat and high-carbohydrate meal are attenuated by ingestion of the flavonol quercetin.

Methods

Twenty-two overweight-to-obese hypertensive patients participated in a randomized, double-blind, controlled, crossover meal study. They consumed a test meal (challenge) rich in energy (4754 kJ), fat (61.6 g), saturated fatty acids (53 % of total fatty acids), and carbohydrates (113.3 g) with either placebo or 54 mg quercetin. Blood pressure, reactive hyperemia index (RHI), high-sensitive C-reactive protein (hs-CRP), soluble endothelial-derived adhesion molecules, parameters of lipid and glucose metabolism, and markers of antioxidant status were measured before the meal and at 2 and 4 h postprandially.

Results

Systolic and diastolic blood pressure increased significantly over time, but were not affected by treatment (placebo or quercetin). During both treatments, serum endothelin-1, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and plasma asymmetric dimethylarginine slightly decreased over time, whereas RHI increased. Serum triglycerides, total cholesterol, and insulin significantly increased, whereas HDL cholesterol and glucose significantly decreased over time, again with no effect of treatment. Plasma α-tocopherol significantly increased, and plasma Trolox equivalent antioxidative capacity decreased over time. Serum hs-CRP, plasma retinol, and β-carotene did not significantly change during the trial.

Conclusion

In hypertensive patients, a high-energy meal did not lead to postprandial impairment of vascular endothelial function. Postprandial metabolic responses induced by the challenge, such as lipemia and insulinemia, were not attenuated by the concomitant ingestion of quercetin.

Clinical trial

This trial was registered at www.germanctr.de/ and http://apps.who.int/trialsearch/ as DRKS00000555.

Keywords

Quercetin Blood pressure Postprandial metabolism Cardiovascular diseases Endothelial function 

Abbreviations

ADMA

Asymmetric dimethylarginine

CVD

Cardiovascular diseases

FMD

Flow-mediated dilatation

hs-CRP

High-sensitive C-reactive protein

NO

Nitric oxide

PAT

Peripheral arterial tonometry

RHI

Reactive hyperemia index

RM-ANOVA

Repeated-measures ANOVA

sE-Selectin

Soluble endothelial selectin

sICAM-1

Soluble intercellular adhesion molecule-1

sVCAM-1

Soluble vascular cell adhesion molecule-1

TEAC

Trolox equivalent antioxidative capacity

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Verena Brüll
    • 1
  • Constanze Burak
    • 1
  • Birgit Stoffel-Wagner
    • 2
  • Siegfried Wolffram
    • 3
  • Georg Nickenig
    • 4
  • Cornelius Müller
    • 4
  • Peter Langguth
    • 5
  • Birgit Alteheld
    • 1
  • Rolf Fimmers
    • 6
  • Peter Stehle
    • 1
  • Sarah Egert
    • 1
  1. 1.Department of Nutrition and Food Sciences, Nutritional PhysiologyUniversity of BonnBonnGermany
  2. 2.Institute of Clinical Chemistry and Clinical PharmacologyUniversity Hospital BonnBonnGermany
  3. 3.Institute of Animal Nutrition and PhysiologyChristian-Albrechts-University KielKielGermany
  4. 4.Department of Cardiology, Angiology and PneumologyUniversity Hospital BonnBonnGermany
  5. 5.Institute of Pharmacy and Biochemistry, Department of Biopharmaceutics and Pharmaceutical TechnologyJohannes Gutenberg UniversityMainzGermany
  6. 6.Institute of Medical Biometry, Informatics and EpidemiologyUniversity Hospital BonnBonnGermany

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