European Journal of Nutrition

, Volume 56, Issue 3, pp 1169–1177

Association between dietary carbohydrate intake, glycemic index and glycemic load, and risk of gastric cancer

Original Contribution

DOI: 10.1007/s00394-016-1166-4

Cite this article as:
Ye, Y., Wu, Y., Xu, J. et al. Eur J Nutr (2017) 56: 1169. doi:10.1007/s00394-016-1166-4

Abstract

Purpose

The association between dietary carbohydrate intake, glycemic index (GI) and glycemic load (GL), and risk of gastric cancer (GC) has been investigated by many studies. However, the results of these studies were controversial. The aim of our study was to systematically assess this issue.

Methods

PUBMED and EMBASE were searched up to March 2015, and either a fixed- or a random-effects model was adopted to estimate overall relative risks (RRs). Dose–response, meta-regression, subgroup, and publication bias analyses were applied.

Results

Twenty-six studies with approximately 540,000 participants were finally included in this meta-analysis. High level of dietary carbohydrate intake (pooled RR 1.17, 95 % CI 0.91–1.50), GI (pooled RR 1.17, 95 % CI 0.80–1.69), and GL (pooled RR 1.06, 95 % CI 0.90–1.26) were all nonsignificantly associated with incidence of GC. In addition, no significant dose–response relationship was observed between carbohydrate intake, GI and GL, and the risk of GC. However, further subgroup analyses based on gender and geographic region suggested a significant association between higher carbohydrate intake (pooled RR 1.52, 95 % CI 1.10–2.08), GL (pooled RR 1.41, 95 % CI 1.04–1.92), and GC risk in males subgroup, and between higher carbohydrate intake (pooled RR 1.69, 95 % CI 1.36–2.09) and GC risk in Asian studies.

Conclusions

No significant association was found between dietary carbohydrate intake, GI and GL, and risk of GC. However, significantly positive association was observed in the males subgroup and Asian studies.

Keywords

Carbohydrate intake Glycemic index Glycemic load Gastric cancer 

Supplementary material

394_2016_1166_MOESM1_ESM.docx (26 kb)
Supplementary material 1 (DOCX 26 kb)
394_2016_1166_MOESM2_ESM.tif (6.8 mb)
Supplementary material 2 (TIFF 6947 kb)

Funding information

Funder NameGrant NumberFunding Note
National Natural Science Foundation of China
  • 81172692
  • 81373036
Zhejiang Provincial Department of Science and Technology
  • 2013C14016
China Postdoctoral Science Foundation funded project
  • 419000-X91301

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of ToxicologyZhejiang University School of Public HealthHangzhouChina
  2. 2.Department of Oncology, Second Affiliated HospitalZhejiang University College of MedicineHangzhouChina
  3. 3.Department of Epidemiology and Health StatisticsZhejiang University School of Public HealthHangzhouChina
  4. 4.Jinhua Central HospitalJinhua Hospital of Zhejiang UniversityJinhuaChina
  5. 5.Zhejiang University School of Public HealthHangzhouChina

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