European Journal of Nutrition

, Volume 55, Issue 5, pp 1813–1821 | Cite as

Resistant starch for modulation of gut microbiota: Promising adjuvant therapy for chronic kidney disease patients?

  • Cristiane MoraesEmail author
  • Natália A. Borges
  • Denise Mafra


The gut microbiota has been extensively studied in all health science fields because its imbalance is linked to many disorders, such as inflammation and oxidative stress, thereby contributing to cardiovascular disease, obesity, diabetes and chronic kidney disease (CKD) complications. Novel therapeutic strategies that aim to reduce the complications caused by this imbalance have increased in recent years. Studies have shown that prebiotic supplementation can beneficially modulate the gut microbiota in CKD patients. Prebiotics consist of non-digestible dietary soluble fiber, which acts as a substrate for the gut microbiota. Resistant starch (RS) is a type of dietary fiber that can reach the large bowel and act as a substrate for microbial fermentation; for these reasons, it has been considered to be a prebiotic. Few studies have analyzed the effects of RS on the gut microbiota in CKD patients. This review discusses recent information about RS and the potential role of the gut microbiota, with a particular emphasis on CKD patients.


Microbiota Gut Uremic toxins Prebiotic Kidney disease 


Compliance with ethical standards

Conflict of interest

The authors declare there are no conflicts of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Cristiane Moraes
    • 1
    Email author
  • Natália A. Borges
    • 2
  • Denise Mafra
    • 1
    • 2
  1. 1.Graduate Program in Cardiovascular SciencesFluminense Federal University (UFF)NiteróiBrazil
  2. 2.Medical Sciences Graduate ProgramFederal University Fluminense (UFF)NiteróiBrazil

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